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HOMEMEDICINEDiabetes

Alpha Lipoic Acid Treatments

Published on January 28, 2010

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Alpha Lipoic Acid has several benefits for people with diabetes. Lipoic Acid is soluble in both fat and water. It is capable of regenerating several other antioxidants back to their active states, including vitamin C, vitamin E, glutathione, and coenzyme Q10. ALA. It enhances glucose uptake in type 2 adult onset diabetes, inhibits formation of AGEs (advanced glycation end products). Lipoic Acid has been used to improve diabetic nerve damage and reduce pain associated with that nerve damage.

Dr. Bert Berkson tells us, “An alarming number of adults, even adults in their 20s, suffer from a pre-diabetic state. The high-carbohydrate, high-sugar diet that is so popular in America overloads the body’s response to sugar. This has the effect of altering the body’s use of insulin, the hormone that controls blood sugar levels. A lot of research has focused on ALA’s ability to stimulate the insulin response and get people back to normal blood sugar levels. I’ve seen fantastic results using ALA to reverse all stages of diabetes.” ALA also chelates mercury!

Natural Medication for Diabetic Neuropathic

Diabetic neuropathy, a complication of both type one and type two diabetes, is probably the most common complication of the disease.[1] Studies suggest that up to 50% of people with diabetes are affected to some degree. Diabetic neuropathy is a nerve disorder caused by diabetes. The two main classifications of neuropathy are peripheral neuropathy, affecting the extremities, arms, legs, hands and feet, and autonomic neuropathy, affecting the organ systems, mainly affecting the nerves of the digestive, cardiovascular systems, urinary tract and sexual organs.

Several open studies show benefits for oral Alpha lipoic acid in reducing symptoms of diabetic peripheral neuropathy .

For pain relief for diabetic neuropathy, take 300-600mg of the proper form of Alpha Lipoic Acid daily.

The DEKAN (Deutsche Kardiale Autonome Neuropathie) study followed 73 people with diabetes who had symptoms caused by nerve damage affecting the heart. Treatment with 800 mg daily of oral ALA showed statistically significant improvement.[2]

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Preliminary evidence suggests that Alpha lipoic acid may improve other aspects of diabetes as well, including circulation in small blood vessels, metabolism of sugar and protein, and the body’s response to insulin.

One study by Dr. Bert Berkson has shown benefit for alpha-lipoic acid as part of a combination “triple antioxidant” therapy for hepatitis C with liver failure.

The amount of ALA used in research to improve diabetic neuropathies is 600-1800 mg per day and 200 mg per day for glaucoma. 200 mg per day is recommended for general antioxidant protection in healthy people.

Alpha-Lipoic Acid helps: deactivate free radicals, extend the action of other antioxidants, Release energy from food, and maintain proper glucose metabolism. The body makes small amounts of alpha lipoic acid. ALA has several potential benefits for diabetics. It enhances glucose uptake in non-insulin-dependent diabetes (NIDDM), inhibits glycosylation (the abnormal attachment of sugar to protein), and has been used to improve diabetic nerve damage and reduce pain associated with that nerve damage.

There is preliminary evidence that ALA, taken in the amount of 150-200mg daily for one month, improves visual function in people with glaucoma. ALA has been shown to inhibit the replication of the HIV virus in the test tube. ALA has been given to people who have eaten poison mushrooms, significantly increasing the survival rate. ALA is presently used in therapy for a variety of liver and kidney disorders due to free radical damage.

[1] Mary L. Johnson, RN, CDE, International Diabetes Center, Minneapolis, Minnesota, and colleagues[12] evaluated 206 persons for the microvascular complications of peripheral neuropathy, retinopathy, and nephropathy. On average, subjects had diabetes for approximately 10 years and demonstrated good glucose control (hemoglobin A1C 7.3% ±1.4%). Forty-eight percent of study subjects had microvascular complications, even though they had generally good glycemic control and a relatively short duration of diabetes. Diabetic nephropathy was identified in 20% of the study population; retinopathy was identified in 11%; and symptoms of diabetic peripheral neuropathy were identified in 63%. Diagnosis with a 10-g Semmes-Weinstein monofilament only identified 16% of patients with neuropathy. However, over 30% of the subjects exhibited sensory deficits after clinical examination.

www.medscape.com/ viewarticle/508218

[2] – Ziegler D, Schatz H, Conrad F, Gries FA, Ulrich H, Reichel G 1997 Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Diabetes Care 20:369–373[Abstract

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Dr. Mark Sircus AC., OMD, DM (P)

Director International Medical Veritas Association
Doctor of Oriental and Pastoral Medicine

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comments

For questions pertaining to your own personal health issues or for specific dosing of Dr. Sircus's protocol items please seek a consultation or visit our knowledge base to see if your question may have been answered previously.
  • betsyanne

    What would the dosage of ALA be for a 5 year old child? This sounds like a perfect supplement for my grandchild whom I believe has toxic overload of heavy metals from vaccines. Since it helps with mercury (and a lot of other good things that sound right for my grandchild) I think this would be extremely beneficial for him.

  • Daniel

    Is ALA safe to take while there are still amalgams in the mouth? I only have 1 very small one. Is it safe with one or two amalgam fillings but not safe with a whole mouthful like 10 or more? I don’t understand why ALA would be dangerous with amalgams still present but not other vitamins and minerals.

    • This is a conntroversial subject, even after all these years. Dr. Andrew Cutler, who has his own protocol for chelating mercury, believes using ALA while fillings are present will redistribute the mercury but not remove it from the body. You will have to find him on the Internet to read his views.
      Dr.Sircus knows ways to ensure the mercury is removed using various safe and natural techniques.
      Dr. Bert Berkson has no qualms about using his treatment protocols when amalgams are still present in the mouth.
      Claudia French
      IMVA

      Wednesday, January 21, 2015 8:17 PM
      To: cfrench180@tampabay.rr.com
      Subject: Re: Comment on Alpha Lipoic Acid Treatments

      “Is ALA safe to take while there are still amalgams in the mouth? I only have 1 very small one. Is it safe with one or two amalgam fillings but not safe with a whole mouthful like 10 or more? I don’t understand why ALA would be dangerous with amalgams still present but not other vitamins and minerals.” Settings

      A new comment was posted on Dr. Sircus – International Medical Veritas Association
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      Daniel (Guest):
      Is ALA safe to take while there are still amalgams in the mouth? I only have 1 very small one. Is it safe with one or two amalgam fillings but not safe with a whole mouthful like 10 or more? I don’t understand why ALA would be dangerous with amalgams still present but not other vitamins and minerals.
      8:17 p.m., Wednesday Jan. 21 | Other comments by Daniel

      Reply

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    • Lucas McCain

      No. Always wait 2 or 3 months after amalgam removal to begin ALA therapy. Follow Andrew H Cutler PhD on this.

  • Ricardo

    hey Claudia, I was browsing the web looking for a good or the best R-Ala brand Or supplement but there too many. Any recommendations or specific brand of your personal use ? and thank for all the info and the Dr. protocol, I been drinking my nascent iodine, mega food selenium, organic sulfur and the most important ancient minerals magnesium 🙂

    • We have no particular favorite of brand for Alpha Lipoic Acid, though we definitely recommend people buy the r form and not any with the s form as that combines synthetic with natural….You want only natural and you want the dosage of about 200 mg. and not less.
      Some good sites to check out are:

      Ralapure: http://www.ralapure.com/?gclid=CILH9fO_978CFScV7AodHlMAKA

      Geronova Research: http://geronova.com/consumers/product-information/
      Be wary of the cheaper products available. These are two good companies whose ALA products I have used, especially since I prefer higher dosages which are available here. (higher than 100mg./tablet) and Geronova has innovative research on ALA,
      Claudia French
      IMVA

  • Megan

    Hello,
    I was wondering if anyone could recommend a good source for alpha lipoic acid where I can buy it from? Thank you

  • anti_banker

    Can it help with liver cancer ?

  • anti_banker

    I seem to have found an answer to my question below on Wikipedia:

    Lipoic acid is found in almost all foods, but slightly more so in kidney, heart, liver, spinach, broccoli, and yeast extract.[16] Naturally occurring lipoic acid is always covalently bound and not readily available from dietary sources. Additionally, the amount of lipoic acid present is very low. For instance, the purification of lipoic acid to determine its structure used an estimated 10 tons of liver residue, which yielded 30 mg of lipoic acid.[17] As a result, all lipoic acid available as a supplement is chemically synthesized.” – so I guess supplement capsule versions of ALA are the only real option as opposed to diet?

  • anti_banker

    Great info on ALA, but I am new to ALA and am wondering were it is derived from ?
    Please edit this article to give more info on what foods, or herbs, or oils contain ALA ?
    Which foods naturally contain ALA as opposed to taking in in supplement form, is it similar to DHA found in Omega 3 fish oils ?
    The balance (ratio) of omega 3 fatty acids to omega 6 fatty acids is also very important and is way out in the modern diet. We eat far to much omega 6 oil which are high in most grains and not nearly enough omega 3 oil from fish and a MINORITY of special plants & grains. Too much Omega 6 cancels out the omega 3 and causes a highly inflammatory environment in the human body. The easy way to fix this without needing to look at the right omega oil ratio’s through an in depth analysis is simply to double, or triple the amount of fish we eat. To every person reading this right now, how many servings of fish have you eaten in the last 30 days ? (It should be at least 8 ! – 2 per week, but more is better.) Omega 3 fish oil kills cancer cells – google this with the words “science daily” for proof. Omega 3 also helps with arthritis joint pain and good brain and heart health protecting against strokes and heart attacks and even Alzheimer’s.

  • Debbie

    Does R-Alpha Lipoic Acid really work better in the body than the time released Alpha Lipoic Acid for diabetes and help with the liver? Thanks.

    • Claudia – IMVA Staff

      Debbie,

      r-ALA is the best type to get. If your time-release ALA is a combination of the r and s-ALA it is less effective and can be more harmful than helpful.

  • Ravyn Guiliani

    I have tried to take this supplement but it gives me very bad stomach pain. Any suggestions? It is not as bad if I eat first but I still get a warm flush and cramping and nausea.

    • Claudia – IMVA Staff

      Dear Ravyn,

      If you have this type of reaction you should cut back on the amount you are taking and see if that helps. You can try taking it at a different time of day, perhaps bedtime, or with different juice or water. Listen to your body!

  • I’d should check with you here. Which isn’t one thing I often do! I take pleasure in studying a post that may make people think. Also, thanks for allowing me to comment!