The Insulin Magnesium Story

Insulin Magnesium

Magnesium is necessary for both the action of insulin and the manufacture of insulin.

Magnesium is a basic building block to life and is present in ionic form throughout the full landscape of human physiology. Without insulin though, magnesium doesn’t get transported from our blood into our cells where it is most needed. When Dr. Jerry Nadler of the Gonda Diabetes Center at the City of Hope Medical Center in Duarte, California, and his colleagues placed 16 healthy people on magnesium-deficient diets, their insulin became less effective at getting sugar from their blood into their cells, where it’s burned or stored as fuel. In other words, they became less insulin sensitive or what is called insulin resistant. And that’s the first step on the road to both diabetes and heart disease.

Insulin is a common denominator, a central figure in life as is magnesium. The task of insulin is to store excess nutritional resources.This system is an evolutionary development used to save energy and other nutritional necessities in times (or hours) of abundance in order to survive in times of hunger. Little do we appreciate that insulin is not just responsible for regulating sugar entry into the cells but also magnesium, one of the most important substances for life. It is interesting to note here that the kidneys are working at the opposite end physiologically dumping from the blood excess nutrients that the body does not need or cannot process in the moment.

Controlling the level of blood sugars is only one of the many functions of insulin.

Insulin plays a central role in storing magnesium but if our cells become resistant to insulin, or if we do not produce enough insulin, then we have a difficult time storing magnesium in the cells where it belongs. When insulin processing becomes problematic magnesium gets excreted through our urine instead and this is the basis of what is called magnesium wasting disease.

There is a strong relationship between magnesium and insulin action. Magnesium is important for the effectiveness of insulin. A reduction of magnesium in the cells strengthens insulin resistance. [1],[2]

Low serum and intracellular magnesium concentrations are associated with insulin resistance, impaired glucose tolerance, and decreased insulin secretion. [3],[4],[5] Magnesium improves insulin sensitivity thus lowering insulin resistance. Magnesium and insulin need each other. Without magnesium, our pancreas won’t secrete enough insulin–or the insulin it secretes won’t be efficient enough–to control our blood sugar.

Magnesium in our cells helps the muscles to relax but if we can’t store magnesium because the cells are resistant then we lose magnesium which makes the blood vessels constrict, affects our energy levels, and causes an increase in blood pressure. We begin to understand the intimate connection between diabetes and heart disease when we look at the closed loop between declining magnesium levels and declining insulin efficiency.

Though it would be a long stretch of the longest giraffe’s neck to compare insulin with chlorophyll we are walking a trail at the very nuclear core of life.  It’s the magnesium trail and we find to our surprise that it takes us into intimate contact with the very structure and foundation of life. The dedication of this chapter is to the beauty of magnesium, to its meaning in life, in health and in medicine.

We were talking about chlorophyll and now insulin and putting magnesium in-between. Walking further along is the DHEA magnesium story and the DNA magnesium story. And then there is the cholesterol magnesium story. Every part of life is in love with magnesium except allopathic medicine which just cannot accept it in all its light, flame and beauty. Thousands of years ago the Chinese named it the beautiful metal and they were seeing something pharmaceutical medicine does not want to see for there is little money to be made from something so common.

In a study from Taiwan, the risk of dying from diabetes was inversely proportional to the level of magnesium in the drinking water.[6]- Dr. Jerry L. Nadler

Dr. Jerry Nadler of the Gonda Diabetes Center at the City of Hope Medical Center in Duarte, California, and his colleagues placed 16 healthy people on magnesium-deficient diets, their insulin became less effective at getting sugar from their blood into their cells, where it’s burned or stored as fuel. In other words, they became less insulin sensitive.

Insulin regulates cholesterol levels. There is a direct connection between the level of cholesterol and the level of insulin.

Magnesium is necessary for both the action of insulin and the manufacture of insulin. Magnesium is a basic building block to life and is present in ionic form throughout the full landscape of human physiology. Without insulin though, magnesium doesn’t get transported from our blood into our cells where it is most needed.

Diabetes mellitus is associated with magnesium depletion, which in turn contributes to metabolic complications of diabetes including vascular disease and osteoporosis. Intracellular depletion is directly connected to the impaired ability of insulin to increase intracellular magnesium during insulin deficiency or insulin resistance. Magnesium deficiency per se has been reported to result in insulin resistance.

Insulin resistance and magnesium depletion result in a vicious cycle of worsening insulin resistance and decrease in intracellular Mg(2+) which limits the role of magnesium in vital cellular processes.[7] Magnesium is an important cofactor for enzymes involved in carbohydrate metabolism so anything threatening magnesium levels threatens overall metabolism. Large epidemiologic studies in adults indicate that lower dietary magnesium and lower serum magnesium are associated with increased risk for type 2 diabetes.[8],[9]

Redistribution of magnesium into cells may cause lower magnesium levels in the serum. Insulin causes this effect.

Researchers at the Institute of Internal Medicine, University of Palermo wrote, “Intracellular magnesium concentration has also been shown to be effective in modulating insulin action (mainly oxidative glucose metabolism), offset calcium-related excitation-contraction coupling, and decrease smooth cell responsiveness to depolarizing stimuli. A poor intracellular Mg concentration, as found in noninsulin-dependent diabetes mellitus (NIDDM) and in hypertensive patients, may result in a defective tyrosine-kinase activity at the insulin receptor level and exaggerated intracellular calcium concentration.” [10]

The link between diabetes mellitus and magnesium deficiency is well known. A growing body of evidence suggests that magnesium plays a pivotal role in reducing cardiovascular risks and may be involved in the pathogenesis of diabetes itself.- Dr. Jerry L. Nadler

Magnesium improves and helps correct insulin sensitivity, which is the fundamental defect that characterizes pre-diabetes, metabolic syndrome and even full blown diabetes and heart disease. An intracellular enzyme called tyrosine kinase requires magnesium to allow insulin to exert its blood-sugar-lowering effects. In several studies, daily oral magnesium supplementation substantially improved insulin sensitivity by 10% and reduced blood sugar by 37%.[11],[12] Magnesium also helps correct abnormal lipoprotein patterns. We would expect to find larger improvements in this increased insulin sensitivity if magnesium is supplemented in a correct way meaning through transdermal and oral methods combined using liquid magnesium chloride (magnesium oil) as compared to the very inefficient oral solid forms commonly used.

Improved insulin sensitivity from magnesium replacement can markedly reduce triglyceride levels.[13] Reduced triglyceride availability, in turn, reduces triglyceride-rich particles, such as very low-density lipoprotein (VLDL) and small low-density lipoprotein (small LDL), both of which are powerful contributors to heart disease. Magnesium supplementation can also raise levels of beneficial high-density lipoprotein (HDL).[14]

Insulin regulates intracellular magnesium levels via activation of Na+/Mg2+ exchange. Insulin’s effect on Na/Mg exchange may explain the low cellular magnesium levels observed in vivo under hyperinsulinemic conditions.[15]

Magnesium is a necessary element for all living organisms both animal and plant. Chlorophyll is structured around a magnesium atom, while in animals, magnesium is a key component of cells, bones, tissues and just about every physiological process you can think of. Magnesium is primarily an intracellular cation; roughly 1% of whole-body magnesium is found extracellularly, and the free intracellular fraction is the portion regulating enzyme pathways inside the cells. Life packs the magnesium jealously into the cells, every drop of it is precious.

Add the story of red blood cells and hemoglobin, which replace the chlorophyll molecule’s magnesium center with ion to function for O2 and CO2 transport, but retains magnesium in other crucial roles, and we are on the essential axis of life that allopathic medicine can address with intensive magnesium therapies.

Magnesium improves insulin sensitivity thus lowering insulin resistance. Magnesium and insulin need each other. Without magnesium, our pancreas won’t secrete enough insulin–or the insulin it secretes won’t be efficient enough–to control our blood sugar. Insulin is a hormone. And like many hormones, insulin is a protein.  Insulin is secreted by groups of cells within the pancreas called islet cells. Insulin is much more important and has many more functions then we realize. It regulates:

  • lifespan -  Lower insulin levels equate to a longer life.
  • blood sugar
  • blood lipids
  • excess nutrients (from glucose, carbs and calories) and converts them to fat
  • builds muscle
  • stores protein
  • magnesium levels in our body
  • calcium levels in the body
  • retains sodium levels
  • cell division
  • growth hormone
  • liver functions
  • sex hormones, estrogen, progesterone, testosterone
  • cholesterol in the body
  • fat in our body

Magnesium is a cofactor for multiple enzymes involved in carbohydrate metabolism.[16] Adipocyte cells placed in low-magnesium media show reduction in insulin-stimulated glucose uptake.[17] Magnesium deficiency is associated with increased intracellular calcium levels, which may lead to insulin resistance. Low erythrocyte magnesium content increases membrane microviscosity, which may impair insulin interaction with its receptor.[18] Tyrosine kinase activity is decreased in muscle insulin receptors of rats fed a low-magnesium diet.[19] These findings indicate that magnesium deficiency directly affects insulin signaling.

When magnesium levels fall hypersecretion of adrenalin and insulin compensate. Their increased secretion help maintain the constancy of the levels in intracellular magnesium in the soft tissues. Plasma and intracellular magnesium concentrations are tightly regulated by insulin. In vitro and in vivo studies have demonstrated that insulin modulates the shift of magnesium from extracellular to intracellular space.

Dr. Ron Rosedale says that, “Insulin floating around in the blood causes plaque build-up. They didn’t know why, but we know that insulin causes endothelial proliferation. Every step of the way, insulin is causing cardiovascular disease. It fills the body with plaque, it constricts the arteries, it stimulates the sympathetic nervous system, it increases platelet adhesiveness and coaguability of the blood.”


[1] Paolisso G, Scheen A, D’Onofrio F, Lefebvre P: Magnesium and glucose homeostasis. Diabetologia 33:511–514, 1990[Medline]

[2] Nadler JL, Buchanan T, Natarajan R, Antonipillai I, Bergman R, Rude R: Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension 21:1024–1029, 1993

[3]Ma J, Folsom AR, Melnick SL, Eckfeldt JH, Sharrett AR, Nabulsi AA, Hutchinson RG, Metcalf PA: Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid wall thickness: the ARIC study. J Clin Epidemiol 48:927–940, 1985

[4] Rosolova H, Mayer O Jr, Reaven GM: Insulin-mediated glucose disposal is decreased in normal subjects with relatively low plasma magnesium concentrations. Metabolism 49:418–420, 2000[Medline]

[5] Resnick LM, Gupta RK, Gruenspan H, Alderman MH, Laragh JH: Hypertension and peripheral insulin resistance: possible mediating role of intracellular free magnesium. Am J Hypertens 3:373–379, 1990[Medline]

[7] Magnesium transport induced ex vivo by a pharmacological dose of insulin is impaired in non-insulin-dependent diabetes mellitus. Hua, H : Gonzales, J : Rude, R K Magnes-Res. 1995 Dec; 8(4): 359-66

[8] Lopez-Ridaura R, Willett WC, Rimm EB, Liu S, Stampfer MJ, Manson JE, Hu FB: Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care 27:134–140, 2004

[9] Kao WH, Folsom AR, Nieto FJ, Mo JP, Watson RL, Brancati FL: Serum and dietary magnesium and the risk for type 2 diabetes mellitus: the Atherosclerosis Risk in Communities Study. Arch Intern Med 159:2151, 1999

[10] Mol Aspects Med. 2003 Feb-Jun;24(1-3):39-52. Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X.Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, Pineo A, Busardo’ A, Paolisso G. Institute of Internal Medicine and Geriatrics, University of Palermo, Via F Scaduto 6/C, Palermo, Italy. mabar@unipa.it

[11] Guerrero-Romero F, Tamez-Perez HE, Gonzalez-Gonzalez G et al. Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab. 2004 Jun;30(3):253-8.

[12] Rodriguez-Moran M and Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care. 2003 Apr;26(4):1147-52.

[13] Yokota K, Kato M, Lister F, et al. Clinical efficacy of magnesium supplementation in patients with type 2 diabetes. J Am Coll Nutr. 2004 Oct;23(5):506S-9S.

[14] Rasmussen HS, Aurup P, Goldstein K, et al. Influence of magnesium substitution therapy on blood lipid composition in patients with ischemic heart disease. A double-blind, placebo controlled study. Arch Intern Med. 1989 May;149(5):1050-3.

[15] Am J Hypertens (2002) 15, 104A–104A; doi:S0895-7061(02)02558-X
P-207: Insulin regulates human erythrocyte Na+/Mg2+ exchange. Ana Ferreira1, Jose R. Romero1 and Alicia Rivera. Pathology, Harvard Medical School; Medicine, Harvard Medical School, Boston, MA, United States

[16] Paolisso G, Scheen A, D’Onofrio F, Lefebvre P: Magnesium and glucose homeostasis. Diabetologia 33:511–514, 1990[Medline]

[17] Kandeel FR, Balon E, Scott S, Nadler JL: Magnesium deficiency and glucose metabolism in rat adipocytes. Metabolism 45:838–843, 1996[Medline]

[18] Tongyai S, Rayssiguier Y, Motta C, Gueux E, Maurois P, Heaton FW: Mechanism of increased erythrocyte membrane fluidity during magnesium deficiency in weanling rats. Am J Physiol 257:C270–C276, 1989

[19] Suarez A, Pulido N, Casla A, Casanova B, Arrieta FJ, Rovira A: Impaired tyrosine-kinase activity of C

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Comments:

  • Wayne D.

    I want to say how thankful I am to have learned about magnesium and how much it has helped me. Thank You Dr. Sircus and Staff.
    I have ankylosing spondilitus, degenerative disc disease, have 4 vertebrae fused together naturally from no discs and calcification of the tendons as well, like hacksaw blades in my back. I am a 59 yr. old disabled electrician.
    I had been prescribed drugs like Enbrel injections and as many pain pills as I could consume. I hated it and quit them ALL. It was not easy.
    This condition causes muscle splinting. My back muscles were always hard as a rock and NEVER let go, from my neck and shoulders to my tailbone, spasms too of course.
    Transdermal Magnesium oil caused my muscles to relax for the first time in 30 yrs.
    I had been to physical therapists who tried everything in their book and nothing wotked, they had to make me stop as my legs were going numb from their protocol.
    They never did use magnesium oil. I think they know and are not telling people.
    I am a conspiracy theorist and I do believe we are seeing the AMA, the FDA and the USDA protect corporate profits over people’s real health.
    I have been losing friends to cancer and am now recommending hemp oil as we have lots up in Washington State and it’s legal.
    I recently discovered the properties of virgin, unrefined, organic coconut oil.
    Along with the magnesium I am having tremendous results.
    I won’t go into a diatribe about coconut oil but it has actually helped reduce my pain as well, for real, I deal with a lot of pain.
    It has also increased my strength and stamina, has anti-viral, anti-fungal, anti-biotic and anti-parasitic qualities, is affordable and available almost anywhere.
    I think you should look into it and consider including it in your site for health enhancement.
    It is also showing great results in reversing alhziemers and dimentia.
    It has medium chain fatty acids the same as in mother’s milk.
    Thank you so much for increasing my quality of life and helping me get off the drugs.
    I am also using Atomic Iodine and taking Selenium and Vit. D3.
    I also have a baking soda and magnesium drink before bed and when I wake up, I think it is helping my energy levels as well.
    I use Celtic Sea salt and have changed my diet to all organic, more raw.
    I am currently feeling better than I did 15 yrs. ago.
    Thank you again Dr. Sircus for sharing this VITAL information. You’ve saved my life.

  • mhikl

    Dr Sircus, such interesting information. I have been researching magnesium since the early seventies when my mum collapsed and was rushed to hospital for a severe potassium deficiency. After her painful infusion of potassium she was instructed to eat potatoes and bananas. Through the year she ended up in hospital a number of times for the same problem. Meanwhile I was reading everything I could get my hands on from the second hand book store below where I lived. Then I chanced upon a small book that explained that there were four electrolytes, sodium, potassium, magnesium and calcium with magnesium being the great regulator. Just recently I read about the relationship between magnesium, calcium and phosphorous and began a search on phosphorous and found a site “US Medical Library” that had a short introductory piece that said there were five electrolytes, phosphorous being the fifth one.
    Naturopath and chemist researcher, Walter Last, has been a good fellow to read for information on this subject recently and you have added further elements of interest for my study. It is interesting to see the relationship to insulin. I suspect this wonder element can clear up a lot of loose pieces in the health of our nations. I once read a doctor who said if magnesium was pushed instead of calcium we could empty our hospitals.
    I have lost three family members to the lack of magnesium in our waters and foods and other members show similar signs to the deficiency problems the others had, but none seem interested in the topic as their doctors all assure them their magnesium levels are find. They are all advised to add calcium to their diets. I am aghast but the old adage of the horse being led to water stands true.
    Here is my dream: that Allopathy accepts that it is the body that heals itself and not some mystic doctor whose main responsibility is to education his/er client along that path. When medical doctors get as much education in nature’s healing ways as they do the chemical treatments that bring in the big bucks, then we will have true doctors of the Hippocratic Oath.

  • Rod

    Hi Joe great response many thanks, as one question/answer leads to another and then clarity is obscured by brain cells! Sad to say I was non exam, now 58 and certainly try to comprehend, but love your answer, so many thanks.

    My notes! – So MgCl2 weighs 95 on some scale and is made up of 24 parts which could be(mgms/gms/tons) of magnesium and 71 parts of Chloride, (approx!)

    With Glucose weighing in at 180 parts. So now comes the vital important part and that is how the 180 is converted into useable energy?

    So where do people get 28 or 56 molecules of magnesium for metabolising glucose from?

    My partner asks (1)would it not take 3 molecules of magnesium to metabolise 1 molecule of sugar to balance the equation?(she went to uni and loved chemistry in high school!)

    I suppose in simple way its about the two coming together? MgCl2+C6H12O6, but then whats this Krebs Cycle? Will keep researching and await your findings or best guess.

    All the best Rod

  • http://edistone.ro Joe Boylan

    Hi Rod,
    Just that ‘one more question’ is probably the crucial one which we ought to know to begin to understand all this stuff. So I will try to be brief and as clear as I can make it. This stuff is so badly taught in school! No! A molecule of sugar is not the same weight as a molecule of magnesium.

    In our environment we have 103 elements and a huge number of compounds. The smallest part of an element is called an atom and the smallest part of a compound is called a molecule. All the compounds are composed of different numbers of elements. A bit like the letters of our language and the words we use to speak with. The elements are the letters and the compounds are the words. Magnesium is actually an element but sugar is most definitely a compound. The smallest part of an element is often called a molecule because even the element’s smallest parts often ‘travel round’ in twos and threes or more.

    Eating magnesium on its own would be very difficult so we would eat it in some compound, e.g. magnesium chloride. There are many sugars and each one is composed of an arrangement of Carbon atoms, Hydrogen atoms and Oxygen atoms. Hence they are called Carbo-hydr-ates. The simplest sugar is called Glucose and when it is present in fruit it is called Fructose. Glucose and Fructose are called Primary sugars. Cane sugar is a Secondary sugar and is the sugar we put on the table generally. Tertiary sugars are not actually even sweet. One example is Starch as in potatoes and flour. Now I hope I have not confused you so far and that you are still with me. It sounds a little pretentious but please ‘take notes’ up to now. If YOU write out what I have just described in your own way, I think it will be easier to remember for the next step.

    We now come to atomic mass and formulae. Every element’s atoms have a mass (weight) but we don’t measure it in grams because it is too small. Instead we compare it to the atomic weight (the weight of one atom) of the lightest element which is hydrogen. For example Hydrogen is 1, Helium is 4 because it is 4 times as heavy as hydrogen; Carbon is 12; Oxygen is 16; Magnesium is 24 and Chlorine is 35.5. (The rest of the 103, you can find in any good standard school chemistry text-book; e.g. “Investigating Chemistry” by Davies, Denial, Locke and Reay, published by HEP Heinemann Educational Books [my edition is 1973 – and I can recommend it] see inside front and back cover.)

    Now to analyse the molecular weights: Firstly Magnesium Chloride, formula MgCl2 which means one atom of magnesium and two atoms of Chlorine. The weight of one molecule of MgCl2 therefore is 24+2×35.5=95. Very significant at this point! Now the formula of glucose is C6H12O6 which if you use the same method of calculation (please work it out yourself) you will get 180 which is approximately twice the molecular weight of Magnesium chloride.

    Now these weights (in H atom units) can be simply changed to weights in grams (or milligrams, ounces, etc.) in a very straight-forward way. We can say that the molecular weight of MgCl2 is 95 and of sugar is 180, which should answer your question Rod.

    Final step: If you dissolve the molecular weight (in grams) of Magnesium chloride or Glucose in one litre of water (distilled) you get what we call a molar solution or a normal (N) solution of that chemical. A normal solution of one chemical such as an acid, should neutralize (note – not metabolize) a normal solution of an alkali.

    Now that just about covers the basics. I have simplified it somewhat to make it easier to follow so I hope it is. That is as far as I can go with this in Chemistry for you and now I must leave you to try to bone up on metabolism if you don’t mind. I will do what I can. I looked at a number of “answers” from various parts of the Internet the other evening some of them from very ‘bright’ sounding people but they were all so vague. Nothing specific for metabolism! I will try to write another short paper when I get some worthwhile explanations or failing that I will work something out myself!!

    Best, Joe Boylan

    PS for Claudia: Hi Claudia. Is it possible to have a tag for subscript because my formulae don’t look right and may confuse people without it. E.g MgCl2 is really Mg Cl 2(Subscript) and not C 12. Many thanks. Joe

  • sarah

    Hi I was reading the blog and I could not find an answer to this persons question (see below)which is the same as mine, regarding zinc levels and other vitamins.

    Karen Ritchey said:
    Hi, I just started using the Ancient Minerals mag oil, I think I like it, it’s just been a week now….I read the questions above with interest and have learned much, but one question has not been addressed…With the use of mag oil, will it interfere with zinc levels and other mineral levels? Similiar to taking B vitamins, they say to take them together and at the same dosage. Will using mag oil upset zinc and other mineral levels, therefore causing a deficiency, in those other mineral levels? Should one then start taking zinc supplements and such? Thank you. Karen

    • Claudia French – IMVA Staff

      Hi Sarah,

      So many people are remarkably deficient in magnesium that using magnesium oil as prescribed by Dr. Sircus should not interfere with other minerals like zinc. Of course we should all be making attempts to have a balanced intake of all the needed vitamins and minerals. To our knowledge magnesium will not cause a zinc deficiency. Please let us know if you have other information on this.

      Magnesium and calcium of course need to remain at a 1:1 intake level as each depends on the other for proper absorption.

  • Rod

    Thanks Joe for your update and would wholeheartdely agree with getting things sorted out for the benefit of the consumer. I often begin to ask myself a question which can be aimed at any medical profession ie Vets or Doctors, as their jobs depend on animals or people being ill will they ever want every animal or person to be fully healthy? Otherwise why is not more done to test and promote ‘remedies’ that many say can change your entire life! Did you have read a book by I think Dr Mackeness who back in the 50′s emptied a ward under his care by changing their diet? he was reported sacked and disgraced by his peers, and the ward returned to normal capacity once more, everyone safe with their jobs.
    Just one last question regarding molecules, is a molecule of sugar same weight as a molecule of magnesium?
    Many thanks

  • http://edistone.ro Joe Boylan

    Hi Rod,

    There isn’t really a problem with our understanding of the science behind all this if we understand some basic maths. If you think about it, it is not important what units you work in: pounds, molecules, grams, milligrams or even tonnes, as long as you work in the same units all the time. It is just a question of ratio.

    Molecules and grams are familiar to me as a scientist and like most scientists we like our maths simple. We have too many other things to slow down our work without using such archaic measures as pounds, ounces, stones, hundredweights, etc., and such like. These measures really are medieval. That’s is because the equivalents are all over the place; 16 ounces=one pound, 14 pounds=one stone and so on. Why? In the Fahrenheit thermometer scale it is just the same – only different!! The even bigger problem here is that conversion from one system to the other is essential making life even more complicated.

    When the British finally went over to a metric system for money there was uproar. I was Head of Maths in the school I taught in and my headmaster said to me: “Now Boylan what are you going to do about teaching the girls and boys how to convert from the the old sterling system to the metric?” My reply was short and sweet. I said we are going to forget about the old system as quickly as possible. What is the point of burdening the pupils with conversion on top of trying to preserve a useless system just for the sake of nostalgia? I am buying new textbooks which don’t even mention the old system and I will teach everyone to think metric from now on.

    That is what we did. You see the education authority and the gov. had overlooked the fact that about 20 years before that, the computer had arrived and digital counting was in. It began to dawn on everybody that pounds shillings and pence was another medieval process which no-one really needed anymore.

    Now my point for all this digression is that the food and nutrition business must also still be in uproar and no-one is doing anything about it. This must account, at least in part, for all the confusion and chaos. The sooner this ‘industry’ sorts itself out, the better for everyone don’t you think?

    Now if I go off-line for a bit I will try to find out some more about metabolism for all our sakes and perhaps someone will try to get hold of some nutritionists to help – please?

    Meanwhile, best for now, Joe

  • Rod

    Hi joe food for thought indeed! the figures were kind of from memory! but thats seen better days. Here are some to help as you can see there is a wide range.

    here is what http://www.netdoctor.co.uk/diet-and-nutrition/healthy-eating/eat-your-way-to-a-normal-blood-pressure.htm say “For example, about 56 molecules of magnesium are required to metabolise just 1 molecule of sugar”

    As the Weston Price Foundation states:

    “A diet of processed, synthetic foods, high sugar content, alcohol and soda drinks all “waste” magnesium, as a lot of it is required for the metabolism and detoxification of these largely fake foods. According to Dr. Natasha Campbell-McBride, the body requires at least twenty-eight molecules of magnesium to metabolize a single molecule of glucose. Phosphates in carbonated drinks and processed meats (so-called “luncheon meats” and hot dogs) bind with magnesium to create the insoluble magnesium phosphate, which is unusable by the body.

    http://www.westonaprice.org/health-issues/your-body-on-drugs say 54

    http://www.facebook.com/permalink.php?id=175402889165319&story_fbid=451446791560926 say 59!

    It requires 45 molecules of magnesium to metabolize 1 molecule of sugar. Make sense why so many Americans are deficient? And yes, soil depletion is another important factor comes from http://www.acne.org/messageboard/index.php/topic/312135-the-effects-of-mineral-imbalance-on-mineral-absorption-insulin-resistance-and-acne/

    So as you can see a huge ammount of information or misinformation there is out there. Why they use this langauge when most of the population does not comprehend words like metabolise or especially molecule why not use milligrams or better still grams tho have to confess due to age would prefer ounces!! 58 is my age in numbers.

    Cheers
    Rod

  • http://edistone.ro Joe Boylan

    Hi Claudia and Rod,

    Fascinating stuff isn’t it?

    Firstly Claudia there is nothing lowly about an RN. we all have our own ‘expertise’ and our part to play in the work. What we really need are some food chemists not just plain old chemists like me on board. I am not even sure whether Dieticians would fill the bill, which is why I thought it could take some time to find the answers here. I am actually a retired science teacher for what it is worth but I can’t even locate the real answers to this question from my old text books. I have a small library of medical tomes to plough through but that is going to take me some time too.

    Rod can you tell me where you get your figures from of 35, 54 and 56. When I ran my calculations of equivalent weights etc., everything checked out that 95 gm of Magnesium Chloride (MgCl2) is equivalent to 180 gm of glucose (C6H12O6), but I am more than certain that equivalent weights are not the same as metabolism rates and that is where we need the food chemists to help. What amazes me is that if your figures are true then 50 gms of MgCl2 to ONE gm of glucose would mean taking in a colossal amount of MgCl2 for all the sugar we take in – in our diet on a daily basis.

    I have seen figures that we eat some 180 pounds of sugar per year at this time whereas in the 1700′s we only ate about half a pound per year. (“Hell’s Kitchen” by Dr Joel D Wallach 2005, p 233). To even begin to cope with metabolizing 180 pounds of sugar you are talking about MgCl2 in the thousands of pounds per year at 50 gm/1 gm. So something is very wrong with our calculations and we need to get some expert advice.

    All good food for thought though – pardon the pun.

    Best Joe.

  • Rod

    Hi joe

    thanks for the response, though I am sure you will understand my dissapointment in my quest to seek a very straight forward answer to my question.

    If it takes approx 50 molecules of Magnesium to metabolise 1 molecule of sugar this would appear to be very important information to any future customer trying to understand why they need to take magnesium. I would have thought your company would have this kind of information ready at hand and if not why not? Surely it is a vital piece of information to understand why magnesium is essential whether taken through the mouth or the skin.

    lets use the figures 50 to 1 as milligarms or grams! instead of these molecules whatever they are. If you were to take in 1 gram of sugar per day you would need 50 gms of magnesium, per day. If a person did not take it then surely they would have to use their own supply,which is stored in bones etc. Which means they would destroy their own store of Magnesium.

    Magnesium is as I understand vital for helthy functions of every living cell, it moves calcium around to where it belongs (bones) and not heart/artieries etc as deposits. Again I am led to understand without magnesium in balance in the body, Insulin levels rise with glucose levels and these get stored as fat especially around the middle ( my big problem)so to help me understand WHY I need to transdermally or via ingestion to take so much Magnesium in order to restore balance and health, I am researching to give me clear explanations.

    I believe in magnesium it all makes sense when I see the illnesses and problems in modern life we have. Hopefully you can pass this on to someone who can answer, as I feel this is important to help me and others understand why Magnesium is so important.

    Many thanks

  • http://edistone.ro Joe Boylan

    Hi Rod,

    I am a scientist but I don’t think you should try to bother your head with all the detailed specifics. You will be getting into Molecular Weight; Moles; molar concentration and what!! I can’t even imagine what your three sets of figures mean because I am not a food chemist, but what I would say is have a read through this extract sent to me from Claudia, one of the IMVA assistants a few months ago when I asked her for details of treatment quantities.

    “Author: Claudia French – IMVA Staff
    Comment:
    Dear Joe,

    Transdermal magnesium can be applied at the rate of 1-2 oz. per day on the skin. The amount depends on the size of the person as to how much they actually need, and on how deficient they are. There is little danger in using too much as healthy kidneys will excrete any excess taken in very shortly. But kidney functioning must be in good working order. The only magnesium compound that IMVA endorses and recomends is Ancient Minerals Magnesium Oil from LL’s Magnetic Clay co. It is the most pure and quality controlled magnesium oil. We do not recommend any oral magnesium products because generally they are not found to elevate magnesium levels as quickly as transdermal application will. Diarrhea is a limiting factor in getting enough magnesium from any oral form. Only about 30-40% of the magnesium you think you are ingesting is actually being absorbed. With magnesium oil you by-pass the gut and its associated absorption problems.

    Magnesium oil should be applied liberally for about 3-4 months till your body has reached a normal level if you are deficient. Then you can cut back on the amount used. Two oz. per day is the maximum anyone should need and thats really quite a lot. Some people need to dilute till their skin becomes accustomed and this can be done by adding half spring water to the magnesium.”

    You see I do know the bit about “the body knowing when…” If you ignore the clinical quantities and just ‘get on with it’ as Claudia says, I think you will be okay. Knowing how many mgs of MgCl2 will metabolize one mg of glucose is something for the real experts in this field. If you are not even a chemist as you say it could take you years to find this out.

    Best of luck with it all
    Joe Boylan

    • Claudia French – IMVA Staff

      Hi Joe,

      Just wanted to say thanks for your help iin annswering this!! I’m not a chemist either, just a lowly RN, but you are right we would need some chemists on board to give all the requested details and it is far better to just get on with it as long as people observe the cautions about needing good kidney functioning! Again, Thanks!

  • Rod

    In researching magnesium in the human body I came across several references to the need for magnesium to metabolise Glucose in the body. I have seen figures of 35, 54 and 56 molecules of Magnesium to metabolise 1 molecule of glucose. Not been a scientist or chemist I tried to find out in layman’s term what this means but had little success.

    Could you help by explaining how much (X) gms or milligrams is needed of magnesium to metabolise (X) gms or milligrams of glucose. Surely this is vital information when trying to help people understand why reducing a diet of unnecessary sugars and restoring magnesium levels to good effective levels?

  • Karen Ritchey

    Hi, I just started using the Ancient Minerals mag oil, I think I like it, it’s just been a week now….I read the questions above with interest and have learned much, but one question has not been addressed…With the use of mag oil, will it interfere with zinc levels and other mineral levels? Similiar to taking B vitamins, they say to take them together and at the same dosage. Will using mag oil upset zinc and other mineral levels, therefore causing a deficiency, in those other mineral levels? Should one then start taking zinc supplements and such? Thank you. Karen

  • Alexandra

    My husband is a type 1 insulin dependant he takes insulin 3x times a day before meals also he takes 2x a day byetta apart from oral medication 2x metformin 1000mg dose ,anyway not to make this more complicated I would like to ask is it safe to use magnesium with all this medication and if yes , directions please he has been battling with this illness for so many years and cannot get it under control .

  • Que dodieu

    Magnesium is necesssary for both the action of insulin and the manufacture of insulin, without or a reduction of magnesium in the cells strengthens insulin resistance which is possible explanation for why brown rice eaters are at lower risk for type 2 dabetes,because in addition to having a lower glycemic index,brown rice also contains important nutrients that are stripped during the refining process,esp magnesium and much more fiber.
    A new study from researchers at Harvard has found that having these nutrients in the diet reduce the risk of developing type 2 diabetes.This,once again consolidates the importance of magnesium for life,it not only plays a pivotal role in reducing cardiovascular risks (abnormal heart rhythm)but may also be involved in the pathogenesis of diabetes.

    • Claudia French – IMVA Staff

      Thanks Que,

      Here’s a link to a news report about this recent piece of research:

      http://www.medpagetoday.com/PrimaryCare/Diabetes/31673

      The study also found a dose-response effect — with each increase in white rice serving per day, risk of type 2 diabetes rose by 11%.

  • http://edistone.ro Joe Boylan

    Hi Claudia,

    Having just become suspicious that my daughter may have a hypoglycemia problem, I too am very interested in specifics. If you are reluctant to suggest actual quantities of which Mg compound to use and how it should be applied (which I quite understand could be interpreted as something like a distant diagnosis followed by a prescription), can you not give a guidance as to how quantities, dosage and method of absorption can be worked out by any individual — please?

    • Claudia French – IMVA Staff

      Dear Joy,

      Transdermal magnesium can be applied at the rate of 1-2 oz. per day on the skin. The amount depends on the size of the person as to how much they actually need, and on how deficient they are. There is little danger in using too much as healthy kidneys will excrete any excess taken in very shortly. But kidney functioning must be in good working oder.

      The only magnesium compound that IMVA endorses and recomends is Ancient Minerals Magnesium Oil from LL’s Magnetic Clay co. It is the most pure and quality controlled magnesium oil. We do not recommend any oral magnesium products because generally they are not found to elevate magnesium levels as quickly as transdermal application will

      Diarrhea is a limiting factor in getting enough magnesium from any oral form. Only about 30-40% of the magnesium you think you are ingesting is actually being absorbed. With magnesium oil you by-pass the gut and its associated absorption problems.

      Magnesium oil should be applied liberally for about 3-4 months till your body has reached a normal level if you are deficient. Then you can cut back on the amount used. Two oz. per day is the maximum anyone should need and thats really quite a lot. Some people need to dilute till their skin becomes accustomed and this can be done by adding half spring water to the magnesium.

      Dr. Sircus gives more specific and individualized recommendations for dosages and additional needed supplements in consultations.

      See: http://naturalallopathicclinic.com/

  • http://google Jenny

    Re hypoglycaemia and too much sodium in the diet

    How does magnesium help hypoglycaemia?

    How does magnesium interact with sodium in your body?

    Especially if you have had a bad diet high in salt and processed foods.

    thank you for your assistance – Jen

    • Claudia French – IMVA Staff

      Dear Jenny,

      Since magnesium is so immportant to insulin production and use it is an absolute necessity even when hypoglycemia might occur in certain people. It helps to stabilie blood sugars and maintain a steady state of insulin production. Spirulina also does this.

      If you have had a diet full of processsed food and high in salt you need to make a lifestyle change and get away from that. You can help your body adjust by using magnesium, clay products……like edible clay and get on a more alkaline diet with more greens and lemon juice in water…it might take awhile. These thins will help to detox your body and magnesium is crucial for this. We all need some salt in our systems and it is important as a regulator of water in our bodies and as a necessary component of the electrical signaling needed. Sodium and chloride are both necessary electrolytes as are mmagnesium and potassium….the cells could not function properly without any of these.. Good quality salt should be used, not refined salt as is usually sold, as it strips the many crucial minerals in the processing.

      For more information you should read Dr. Sircus’ book on Transdermal Magnesium Therapy, and also Dr. David Brownstein’s book on Salt Salt Your Way to Health

      Transdermal Magnesium Therapy is available now in the 2nd edition through Amazon.com or through iUniverse, the publisher. See: for the links. http://blog.imva.info/medicine/transdermal-magnesium-therapy-2

  • Que dodieu

    After one year following the relationship between Mag and Insulin action which has persuaded me that magnesium and insulin are synergies,the presence of magnesium that increases insulin sensitivity and insulin enhances the penetration of magnesium into cells.
    In addition, according to the American Heart Association, maqgnesium has been demonstrated to be effective in bringing down high blood pressure and Japenese researchers also said that Mag may play a pivotal role in relaxing the blood vessels,an effect generally proven to help lower blood pressure.
    Patients with diabetes are often have hypertentions simultaneously,which offers a best prescription of the use of magnesium in those patients.

  • Christine

    No one here ever mentioned Nigari, which is much pure Magnesium Chloride to the Ancient Minerals Magnesium (from the specification sheet numbers that I used to compare them).
    Nigari is made for food additives, it can be diluted in pure water for drinking water usage, the result is to help you clean your body system so as to help you loose weight, this has been used and proved in Japan for years. And many other benefits…

    • Claudia French – IMVA Staff

      Hi Christine,

      Nigari is a fine source for magnesium chloride as long as the nigari obtained is not made of other substances (some are calcium and not magnesium). Haveing used nigari myself, I found it much too watery for transdermal use. It just does not have the same consistency as magnesium oil, so is wasteful when using it transdermally or for massages.

  • Ralph

    I agree with Luis to a point.
    That is a pattern to be careful about and one I watch for myself.

    However if one is to just arbitrarily or randomly select data or information about such an important topic it can be almost useless if not dangerous.

    The possible interactions with all other symptoms, diseases and medicine’s is phenomenal in size.

    I have been studying and researching magnesium for over 10 years now and at one point every waking minute of energy I had when I was quite ill.

    Along time before I heard of Dr Sircus or any other Dr referring to magnesium in a positive accurate light.

    I went way back to the early 1930;s medical reports to find it first then Linus Pauling someone I studied in high school.

    I found out that most modern medical records and doctors have removed, forgotten or just plain ignored magnesium. Possibly because it was not marketable or patentable.

    The first item any medical emergency worker will try to get in your system in an emergency today is magnesium sulfate or a bicarbonate drip.Who cares why really that ignorance proved to me they were wrong or corrupt.

    And now several people are being jailed and persecuted or prosecuted for any reference to any natural ingredient.

    If you want to be careful fine and critical fine I encourage but to be lazy you do so at your own peril. Even after I discovered the right type of magnesium I had to personally discover the righ ta mount and the right application.

    So if you want to listen to me without any effort or research on your part go ahead but its at your risk and peril.

    I will never take oxide or citrate(their both laxatives and industrial and will harm you with long use) either a malate or taurate 500mg to a gram (weaning up to 500mg or a gram daily after six to eight weeks depending on your illnes) and also definitely a magnesium oil on my skin in lymph node areas.You can not just jump into this that would be foolish you must wean and test yourself as you go. You will have herxheimer effects and it will be very difficult.

    If anyone is reading this and thinking of following what I wrote ……Think again. Research it yourself only trust yourself. And that statement has nothing to do with the validity of what I said.

    Yes go ahead and read what Dr Sircus wrote. Verify and learn every medical term he uses, thats how I started and only when you understand those medical terms go back and read all you can on magnesium.

    I did find the right magnesium distribution system and have greatly reduced debilitating effects and Magnesium has made my life bearable again. However I have no idea what it will do for anyone else without doing the same type of research on them.

    I wish you all good luck, you are highly unlikely to find facts and truth and highly unlucky to be able to decipher all of it but it will make you more informed and thus give you a small chance to recover.

  • Luis F Navarro

    It is amazing, all these millions of letters (abc’s), sentences, phrases, etc, etc, etc. and they do not answer to your one single question, what are the is the dosage or instruction, for that you have to continue suffering from cancer, having to spend on the books to make rich this so called Doctor of mercy, it sound as cruel as what they attack and condemn.

    They have the same credibility as the rest of the bandits of the Pharmaceutical labs, Doctors that if they know the answer and they let this happening and all that are making money with the health and suffering of the sick people, it is a case for God.

    I stop reading when I recognize the same trick of the scam articles you find every where.

  • Bob

    Magnesium Chloride is commonly found locally in “ice melt” in 50 pound bags for under $20. How many pounds of ice melt should be mixed in my bath for diabetes?

    • claudia

      We advise being very careful buying what is described as ice melt. Many of these are formulated with proprietary ingredients for hastening the melting of ice and we have learned that some of these ingredients are listed as cancer causing. That’s why IMVA only recommends the most pure source of magnesium chloride in Ancient Minerals Magnesium Oil or flakes. There is no risk of contamination from harmful substances which may not be true in the generally available flakes or salts. If you trust your source or don’t mind taking a chance, you can use magnesium chloride in a pinch at the same rate recommended by Dr. Sircus in his writings….about 1-2 lb per bath. But the purity of Ancient Minerals Magnesium Oil or Bath Flakes cannot be surpassed.

      Sincerely,
      Claudia French

      IMVA

  • Que dodieu

    After learning the topic Magnesium for life ,it’s a very attractive medical information.It has a host of range in metabolism for the body,especially in the diabetic care.But in all diabetes treatment, why didn’t the authors aid Magnesium as and main adjuvant treatment ? “in several studies,daily oral Mag supplementation substantially improved insulin sensitivity by 10% an reduced blood sugar by 37%”
    Thanks
    Que dodieu

  • Lois Lone

    Can you tell me the difference between using Mag Chloride and Mag Sulfide(epsom salts). Will epsom salt also increase Mag levels in the body?

    thanks

    • claudia

      Lois,

      Epsom salts (magnesium sulfate) will raise magnesium levels, but research has shown that the levels of magnesium in your body from bathing in epsom salts do not last as long as from magnesium chloride. Magnesium Chloride has been found to be the safer type of magnesium by Jean Durlach, renowned magnesium researcher.

      Please read the information on the MagnesiumforLife site for more information.

      Sincerely,
      Claudia French RN, LPHA

  • peter wright

    Dear Sir/Madam

    As a diet controlled diabetic – how do I ensue that I get the required amount of Magnesium. What foods contain this metal which I thought was bad for you? Surely the medical profession as a whole know about this
    relatonship.

    Yours

    Peter Wright

    • claudia

      Peter,

      You need to read Dr. Sircus’ books for the information you want. Magnesium is probably the most important mineral in our bodies and it definitely is for diabetes. Look at our other sites for lots of info.
      At the top of tis screen you will see links to many other essays, and at the publlication site http://publications.imva.info/ you can find many books and e-books on magnesium and our book on diabetes: New Paradigms in Diabetic Care.

      As a diabetic myself, I am sorry to tell you that the medical profession is not fully aware of the relationship between magnesium and diabetes. Never once in 40 years of having this disease has any doctor even mentioned the need for magnesium to me. And have not properly tested for it either!

      Today our soils are depleted and even our foods don’t contain adequate magnesium, we would have to eat very large amounts to get adequate daily supplies. Get some magnesium oil and use it daily.

      Sincerely,
      Claudia French RN, LPHA

  • K.Moore

    This an interesting article, but, like many that you find online, it lacks a specific recommendation. I am a healthy 190 lb male. How much MgCL2 do I need per day? Should it be taken with food? How would this dosage change if I was a Type II diabetic?

    While I’m on the topic, why the Chloride? Does the Citrate work as well? I know enough to avoid the Carbonate.

    Thanks in advance.

    • magnesiumforlife

      Kyle,
      Keep reading! There is a tremendous amount of information available on this site with most of the answers to your questions. If you can’t find them on the site they will be in the books available on magnesium. Dr Sircus has prepared an amazing amount of information that he has freely given to people searching here.
      To get you started here is an essay on why magnesium chloride is recommended over other forms of magnesium.

      Claudia French RN, LPHA
      Assistant Director, IMVA

  • Graham Jessop

    Also, i forgot to mention that i have read elsewhere that supplementing with magnesium should be done with extra calcium and zinc as magnesium alone will deplete these other 2 minerals. Can you comment on that also please.

  • Graham Jessop

    Can you explain how this can affect someone (like myself) who has type 1 diabetes?
    My pancreas doesn’t produce insulin, so how can Magnesium supplementation help me.
    By the way, i have never been told any of this information by any of my diabetic doctors.

    • magnesiumforlife

      Hi Graham,
      Even type one diabetics suffer with insulin resistance and can benefit from magnesium use. Now there is even a condition called “double diabetes” where the symptoms of both type one and type two diabetes occur together. Have you seen our new diabetes site? Take a look for more information at: http://diabetic.imva.info/ It is representative of a great deal of information valuable to both types of diabetes, and that is in the new book “New Paradigms in Diabetic Care” available at: http://publications.imva.info/

      For example, both types of diabetics suffer from the same complications. Do you know how fluoride in your drinking water can cause greater kidney problems for diabetics and must be avoided? No doctor will tell you about this either!

      Magnesium can help to stabilize blood sugar in type one’s, can moderate blood pressure, and can have a great impact in preventing or stopping peripheral neuropathy. Magnesium may even help to lower insulin needs, as may use of nascent iodine. Magnesium can prevent some of the heart problems often experienced by type one diabetics, as well as type two diabetics. The information is relevant to both types of diabetics. Even going on a low carbohydrate diet will impact your condition and reduce your insulin needs and the less we have to take of this synthetic insulin, the better off our bodies and our health will be.

      The American Diabetes Association, despite all of the evidence of magnesium’s impact on diabetes, still will not recommend anything but an increase in our diets of magnesium. The evidence that over 80% of diabetics are not getting enough magnesium from our diets does not seem to be enough for the ADA to get the ball rolling . While they can insist that all diabetics need to be on statins, they simply will not recommend magnesium. Perhaps because magnesium is not so tied to the pharmaceutical industry who they prefer to back. Magnesium is so much safer!

      So take heed. Type one diabetics need magnesium as much or more than type two diabetics. Both should be supplementing with magnesium every single day!! Even if we increased magnesium in our diets, due to depletion in our soils, it is almost impossible to get adequate amounts of magnesium.
      Get some magnesium oil from LL’s Magnetic Clay: http://www.magneticclay.com/
      and start using it today.

      I, too, am a type one diabetic, and I only wish I had known years ago, what I now know because of my work with Dr. Sircus. http://diabetic.imva.info/

      Claudia French RN, LPHA
      Assistant Director, IMVA

  • D.Vien

    Hi,
    Very interesting info. Good research info also.
    Where does one buy magnesium chloride in Canada, more specifically northern ontario.
    How does magnesium oxyde, magnesium chelate HvP, and magnesium citrate work in one’s body.
    Thank you for your response.