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HOMEMEDICINEGeneralOxygen

Killing Cancer with Oxygen and Ketogenic Diet

Published on June 10, 2015

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Oxygen is the final acceptor of electrons in the electron transport chain. Without oxygen, the electron transport chain becomes jammed with electrons. Consequently, NAD[1] cannot be produced, thereby causing glycolysis to produce lactic acid instead of pyruvate, which is a necessary component of the Krebs Cycle. Thus, the Krebs cycle is heavily dependent on oxygen, deeming it an aerobic process.

We can literally force mitochondria to become active again and use the Krebs Cycle for energy if we ram enough oxygen into the cells. This process, called Anti-Inflammatory Oxygen Therapy, rockets oxygen into cancer cells so they stop being cancerous (anaerobic) and regain apoptosis, their programmable cell death. If you put enough oxygen into a cancer cell it will turn on the Krebs Cycle (the mitochondria) and this reignites the program for cell death.[2]

Dr. Philipp Mergenthaler and Dr. Andreas Meisel showed that depriving a cell of glucose, while giving it plenty of oxygen at the same time, blocks glycolysis and therefore forces the cell to revive its mitochondria and use the Krebs Cycle for energy.

The citric acid cycle — also known as the tricarboxylic acid cycle (TCA cycle), or the Krebs cycle, is the prime life pump that creates the energy to live. Healthy cells are aerobic, meaning that they function properly in the presence of sufficient oxygen. Healthy cells metabolize (burn) oxygen and glucose (blood sugar) to produce adenosine triphosphate (ATP), which is the energy “currency” of the cells.

Aerobic cellular respiration does require 6 molecules of oxygen for every molecule of glucose. The chemical formula is 6O2 + C6H12O6 –> 6CO2 + 6H2O + ATP energy. The three-carbon sugar, known as pyruvate, and NADH are shuttled to the Krebs Cycle to create more ATP under aerobic conditions. If no oxygen is present, pyruvate is not allowed to enter the Krebs cycle and it is further oxidized to produce lactic acid.

The mitochondria are especially sensitive to light. In fact, the mitochondria are like simple bacteria using light, magnesium, bicarbonates, CO2 and oxygen. They are energy factories like plants are except one is basically creating energy in the form of glucose whereas the mitochondria turn out ATP.

Dr. Robert Rowan says, “Warburg emphasized that you can’t make a cell ferment unless a LACK OF OXYGEN is involved. In 1955, two American scientists, R.A. Malmgren and C.C. Flanigan, confirmed Warburg’s findings. They found that oxygen deficiency is ALWAYS present when cancer develops.”

Warburg found that you can reverse fermentation simply by adding oxygen – but only if you do it early enough. He incubated cells in nitrogen, starving them of oxygen for regular but short periods. Starving the cells of oxygen caused them to begin fermentation and that is where cancer begins. Restoring oxygen promptly enabled the cells to recover.

However the longer they were oxygen starved, the slower and less certain the recovery. With enough oxygen starvation, cells don’t recover. Once they reach a certain point, no amount of oxygen will return them to normal.” But we can make these cancer cells die with oxygen.

Sugar Poisons Oxygen Transport and Absorption

Johns Hopkins Medicine reports that, “Cancer cells have been long known to have a “sweet tooth,” using vast amounts of glucose for energy and for building blocks for cell replication. Now, a study shows that lymph gland cancer cells called B cells can use glutamine in the absence of glucose for cell replication and survival, particularly under low-oxygen conditions, which are common in tumors.”

Writing in the Jan. 4, 2012, edition of Cell Metabolism, Anne Le, M.D., and a team of investigators collaborating with the Johns Hopkins Brain Science Institute, say the finding is critical for developing innovative cancer therapies because it offers "proof of concept" evidence that curbing the growth of B cell cancers can be accomplished by inhibiting a glutamine enzyme called glutaminase. The study also found that when oxygen is scarce, there is enhanced conversion of glutamine to glutathione, an important agent for controlling the accumulation of oxygen-containing chemically reactive molecules that cause damage to normal cells.

One of the main reasons cells lose oxygen is excessive sugar intake. We also know that poisons, preservatives, radiation, or other carcinogens affect a cell’s ability to use oxygen. Warburg said that glucose brings a cell’s ability to use oxygen down. One of the principle ways sugar does this is by creating chronic inflammation in the capillaries and other tissues thus cutting down on oxygen delivery to the cells. When we gorge on the long list of widely available junk foods our cells do not get the oxygen they need to function correctly.

Curing Cancer by Blocking Glycolysis with Oxygen

We can cure cancer by blocking glycolysis with oxygen. This forces mitochondria to become active again and use the Krebs Cycle for energy so that the cells can stop being cancerous and regain apoptosis. The chemical dichloroacetic acid (DCA), which increases the chemical reactions of the Krebs cycle in mitochondria, has been shown to kill cancer cells in laboratory tests and in animals. I never put DCA in the Natural Allopathic protocol because some very severe adverse effects such as encephalopathies, liver problems and severe peripheral neuropathies can occur.

Essentially the Krebs cycle (also known as the citric acid cycle) involves a series of enzymatic reactions that transform proteins (in the form of their constituent amino acids), fats (as their constituent fatty acids) and carbohydrates (as glucose) into intermediate substances. These intermediates are then passed into the electron transport chain where they undergo a further series of reactions – receiving and donating electrons down the chain – to produce energy, in the form of ATP (adenosine triphosphate), CO2 and water. The presence of sufficient oxygen within the cells is essential to the success of this entire procedure, as the term oxidation itself indicates. If insufficient oxygen is delivered to the cells, this entire enterprise will be compromised.

Ketogenic Diet

The most logical, effective, safe, necessary and inexpensive way to treat cancer is to cut off the supply of food to tumors and cancer cells, starving them with a lack of glucose. Sugar feeds tumors and creates general inflammation that is pro-cancer so glucose starvation—that is, depriving cancer cells of glucose—activates a metabolic and signaling amplification loop that leads to cancer cell death.

Research published in June 2013 by researchers from the University of South Florida and Boston College using mice models reported that a "Ketogenic Diet alone significantly decreased blood glucose, slowed tumor progression and increased mean survival time by 56.7% in mice with systemic metastatic cancer. While Hyperbaric Oxygen Therapy alone did not influence cancer progression, combining the Ketogenic Diet with Hyperbaric Oxygen elicited a significant decrease in blood glucose, tumor growth rate and a 77% increase in mean survival times compared to the controls.

Researchers concluded that on its own Hyperbaric Oxygen had no effect on the oxygen-devoid, acidic hypoxic pockets nor on the glucose burning cancer cells. But in combination with a Ketogenic Diet, where the body is starved of glucose, Hyperbaric Oxygen had a significant complementary effect, and it increased survival times.

Abnormal cancer metabolism creates a glycolytic-dependency, which can be exploited by lowering glucose availability to the tumor. The ketogenic diet (KD) is a low carbohydrate, high fat diet, which decreases blood glucose, elevates blood ketones, and has been shown to slow cancer progression in animals and humans. Abnormal tumor vasculature creates hypoxic pockets, which promote cancer progression and further increase the glycolytic-dependency of cancers. Hyperbaric oxygen therapy saturates tumors with oxygen, reversing the cancer promoting effects of tumor hypoxia.

Anti-Inflammatory Oxygen Therapyoffers more oxygen concentration than the best hyperbaric chambers for patients who can get out of their beds and exercise while breathing higher levels of oxygen than ever been given before.

Dr. Jockers reminds us that, “The body has two major energy sources, it burns glucose or ketone bodies. The majority of people burn glucose primarily because they are constantly supplying a steady form of sugar, starches and proteins that can be turned into blood sugar. When one either fasts or goes on a low-carb, moderate protein and high fat diet they switch their energy source to fat. In particular, the fatty acids are broken down into ketone bodies. The three major forms of ketones produced in the body include Acetoacetate, Acetone and Beta-HydroxyButyric acid. These are released into the blood from the liver when insulin levels are low and hepatic liver metabolism is increased.”

One is the easily implemented Budwig protocol, which is better for people who have no intention of coming off their dairy. I say this because for some approaches (Hippocrates and Gerson methods) dairy is off limits. This issue cannot be decided for the patient, it is something they have to decide for themselves.

Dr. Johanna Budwig holds up the nutritional fact that low carbohydrates and high fats of the healthy type have an unusual sway on the outcome of cancer. Their “fast track” potent anti-cancer protocol, when followed properly, has been reported to have an 80-93% success rate.

The Gerson Therapy treats the causes of most degenerative diseases, toxicity and nutritional deficiency by flooding the body with nutrients from about 15-20 pounds of organically grown fruits and vegetables daily. Most is used to make fresh raw juice, up to one glass every hour, up to 13 times per day mostly from raw carrot, apple and green-leaf juices. Raw and cooked solid foods are generously consumed. Oxygenation is usually more than doubled.

So we can clobber cancer by going to the root causes and reverse them. We can flood the body with higher levels of oxygen by taking sodium bicarbonate (without the blackstrap molasses or maple syrup), slow our breathing down, and then flood the body with oxygen with the Live O2 system that simultaneously employs exercise therapy (high levels of carbon dioxide) with a massive flood of oxygen that will carpet bomb the cancer to smithereens.

Of course we do not have to stop here with the annihilation. We can bring in horde armies of iodine, selenium, magnesium and glutathione to increase the chances that none of the enemy remains alive. If we are vigilant with our oxygen intake after successful treatment we can and will hold back recurrences that do eventually come back to haunt the work of modern oncologists who weaken, not strengthen, their patients with extremely toxic tests, chemotherapy and radiation.

[1] Nicotinamide adenine dinucleotide, abbreviatedNAD+, is acoenzymefound in all livingcells. The compound is a dinucleotide, since it consists of twonucleotidesjoined through their phosphate groups. One nucleotide contains anadeninebase and the other nicotinamide.

Inmetabolism, NAD+is involved inredoxreactions, carrying electronsfrom one reaction to another. The coenzyme is, therefore, found in two forms in cells: NAD+is anoxidizing agent– it accepts electrons from other molecules and becomesreduced. This reaction formsNADH, which can then be used as areducing agentto donate electrons.

[2] Proceedings of the National Academy of Sciences of the USA, January 2012

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Dr. Mark Sircus AC., OMD, DM (P)

Director International Medical Veritas Association
Doctor of Oriental and Pastoral Medicine

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comments

For questions pertaining to your own personal health issues or for specific dosing of Dr. Sircus's protocol items please seek a consultation or visit our knowledge base to see if your question may have been answered previously.
  • Edwin Tamasese

    From what I understand I believe the cause of cancer is more related to the reduction in the capacity of hemoglobin to carry oxygen. Most often this is because of glucose displacing oxygen. Anything that fixes itself to hemoglobin and displaces oxygen means that a metabolizing cell will not be able to attach the hydrogen ions created in the metabolic reaction back on to the hemoglobin for removal to the lungs, leaving it in the body, resulting in low pH or acidity. My belief, although there is no research yet to prove this, is that the acidity dissolves the surrounding tissue releasing glutamine in a form that the cancer cell is then able to utilize as an energy source. So even if you do reduce glucose intake, unless you also get rid of the acidity, your treatment is doomed to failure because the cancer is no longer dependent on it to feed off. I believe that the actual benefit of glucose reduction is that, if it is the mechanism displacing oxygen from hemoglobin, it increases the ability to carry oxygen into the cell, and more importantly, increases the ability of hemoglobin to remove hydrogen ions, therefore reducing acidity and preventing the release of “energy available” glutamine.

  • Jake Miller

    I am confused. I thought Dr. Sircus said that one of the causes of PH imbalances is due to High Protein diets. Isnt The ketogenic diet high protein? Help!

    • Andrew

      Keto is not high protein only 20 percent of your intake should be from protein.

  • Mark Sircus

    I have always recommended the Budwig and Gerson approach, both of which aim for lower sugar. Sugar is a poison:

    http://drsircus.com/medicine/cancer/sugar-cancer-growth-research

    • MD

      Is glutamine good or bad (see below)? I currently take a L-glutamine supplement.

      lymph gland cancer cells called B cells can use glutamine in the absence of glucose for cell replication and survival

      when oxygen is scarce, there is enhanced conversion of glutamine to glutathione,
      an important agent for controlling the accumulation of
      oxygen-containing chemically reactive molecules that cause damage to
      normal cells

  • Mark Sircus

    I want to make it clear that I am not suggesting that by itself diet changes cure cancer though they probably always help enormously. Nor am I saying that more oxygen by itself cures cancer. But together, inside of a comprehensive protocol, low sugar and high oxygen make perfect sense.

    • Bill

      Are there any studies matching the dietary habits of people with cancer to the percent of sugar/simple-carbs they have consumed in their diets?

      • Mark Sircus

        not that i know of