New Paradigms in Diabetic Care also examines inflammation and how magnesium is the medical weapon of choice to cut the inflammatory reaction at its source.”If we can block or disarm this macrophage inflammatory pathway in humans, we could interrupt the cascade that leads to insulin resistance and diabetes,” said Jerrold Olefsky, Distinguished Professor of Medicine and Associate Dean for Scientific Affairs.
USCD researchers proved in 2007 that insulin resistance can be disassociated from the increase in body fat associated with obesity and that inflammation provoked by immune cells called macrophages leads to insulin resistance and Type 2 diabetes.  Magnesium deficiency is pro-inflammatory. Magnesium deficiency induces insulin resistance, hypertension, dyslipidemia, endothelial activation and prothrombic changes in combination with the upregulation of markers of inflammation and oxidative stress.
High fructose consumption combined with low dietary magnesium intake can increase the incidence of the metabolic syndrome by inducing inflammation because the corn syrup is contaminated with mercury. Because magnesium acts as a natural calcium antagonist, the molecular basis for the inflammatory response is probably the result of a buildup of the intracellular calcium concentration.
Almost half of tested samples of commercial high-fructose corn syrup (HFCS) contained mercury, according to a new study. Mercury was also found in nearly a third of 55 popular brand-name food and beverage products where HFCS is the first- or second-highest labeled ingredient. HFCS has replaced sugar as the sweetener in many beverages and foods. A high consumer can take in about 20 teaspoons of HFCS per day. The use of mercury-contaminated caustic soda in the production of HFCS is common.
 Potential mechanisms include the priming of phagocytic cells, the opening of calcium channels, activation of N-methyl-D-aspartate (NMDA) receptors, the activation of nuclear factor-kappaB (NFkB) and activation of the renin-angiotensin system. Magnes Res. 2006 Dec;19(4):237-4
 Institute for Agriculture and Trade Policy January 26, 2009. Washington Post January 26, 2009 Environmental Health January 2009, 8:2 The manufacture of corn syrup involves an extensive process, one step of which is to separate corn starch from the corn kernel. Caustic soda is used, among other things, to do this, and for decades mercury-grade caustic soda produced in industrial chlorine (chlor-alkali) plants has been used for this purpose. Because mercury cells are used to produce some caustic soda, the caustic soda may become contaminated, and ultimately transfer that mercury contamination to the HFCS in your soda, salad dressing, soup, cereal, and so on.