Introduction
SECTION - Causes and Characteristics of Cancer - Part 1
INTRODUCTION TO TREATMENTS
Causes and Characteristics of Cancer - Part 2
CHELATION
Hydrogen Medicine
Magnesium Medicine
Bicarbonate Medicine
Iodine Medicine
SELENIUM MEDICINE
Diets, Fasting and Super-Nutrition
CO2, Cancer and Breathing
Oxygen Therapy for Cancer Patients
Cannabis Medicine
Final Considerations

Lesson 21 – Excessive Oxidative Stress as a Fundamental Cause and Characteristic of Cancer

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Oxidative stress is a plague on modern man. Oxidative stress is an imbalance between free radicals/oxidants and antioxidants in our bodies. Free radicals are oxygen-containing molecules with an uneven number of electrons.

“Relation between Oxidative Stress and Carcinogenesis Active oxygen may be involved in carcinogenesis through two possible mechanisms: the induction of gene mutations that result from cell injury and (2) the effects on signal transduction and transcription factors. Which mechanism it follows depends on factors such as the type of active oxygen species involved and the intensity of stress.3) Cellular targets affected by oxidative stress include DNA, phospholipids, proteins, and carbohydrates on the cell membrane. Oxidized and injured DNA has the potential to induce genetic mutation. That some telomere genes are highly susceptible to mutation in the presence of free radicals, is now apparent and it is known that tumor suppressor genes such as p53 and cell cycle-related genes may suffer DNA damage. In addition, oxidized lipids react with metals to produce active substances (e.g., epoxides and aldehydes) or synthesize malondialdehyde, which has the potential to induce mutation.”[1]

When our antioxidant defenses are adequate, damage caused by those free radicals is repaired without many consequences. However when excessive amount of free radicals generates it can damage proteins, lipids, enzymes and DNA that can alter downstream cell signaling and a cause a variety of diseases. Thus free radicals cause deterioration of cell membranes and make cells vulnerable to decay and pathogens. Free radicals also damage the mitochondria. Inflammation, free radical damage and oxidative stress have become major health issues in recent years. (We will deal with inflammation in part two of this lesson.)

Free radicals and oxidants play a dual role as both toxic and beneficial compounds, since they can be either harmful or helpful to the body. They are produced either from normal cell metabolisms in situ or from external sources (pollution, cigarette smoke, radiation, medication). When an overload of free radicals cannot gradually be destroyed, their accumulation in the body generates oxidative stress. The human body has several mechanisms to counteract oxidative stress by producing antioxidants, which are either naturally produced in situ, or externally supplied through foods and/or supplements and now by hydrogen gas. 

There are many factors and variables that contribute to the pathogenesis of cancers such as oxidative stress, DNA damage and mutation, ionizing radiations, carcinogenic chemicals, and more. However, it is important to note that oxidative stress causes DNA damage, ionizing radiation causes oxidative stress and so do heavy metals and chemicals. That is the reason we categorize Excessive Oxidative Stress as a Fundamental Cause of Cancer. Many of the causes we will be studying later lead to higher levels of oxidative stress. Many causes cause inflammation and importantly many causes cause low oxygen (hypoxic) regions  in the body. 

When certain chemicals inside of us have their electron configuration changed, they become very reactive (and are called "free radicals" or "oxidants"). These chemicals roam freely through the rest of the body stealing electrons from other cells. The majority of modern science has come to the conclusion that free radical damage in the human body is an important cause of aging. Aging is evidence of the damage to millions of the body’s cells through oxidation. This oxidation is due to the lack of antioxidants that are available to stop free radical damage.

Whether it’s the toxic pollution in the air you breath 24/7, the radiation your doctor exposes you to,[2] pharmaceutical medicines, chemotherapy, your cell phone constantly at your brain, or even your WI-FI and other EMF pollution generating devices, you expose yourself to oxidative stress,[3] which will drag a person eventually down into disease, cancer or at least premature aging putting an end to happiness, health and even life.

Oxidative stress has been associated with numerous health conditions including chronic fatigue syndrome, fibromyalgia, diabetes, Alzheimer’s disease, anxiety, insomnia, cancer, and just about every disease one can imagine yet doctors seem to ignore this fact and work as hard as they can to increase your oxidative stress when they know we are already against the wall with toxins and stress.

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Imagine a patient, newly in remission from cancer, being exposed every three months to CAT or PET scans, which dramatically increase oxidative stress, just begging for the cancer to come back (or a new cancer to emerge) so they can treat the patient again.

Oxidative stress, directly or indirectly caused by chemotherapy is one of the underlying mechanisms of the toxicity of anticancer drugs in noncancerous tissues, including the heart and brain.[4] During cancer chemotherapy, oxidative stress-induced lipid peroxidation generates numerous electrophilic aldehydes that attack many cellular targets.[5] Oxidative stress, generated by almost all prescribed drugs as they are metabolized, acts as a source of origin and progression of many dreadful diseases. Reactive metabolites formed during this process cause oxidative stress and can impair the function of drug metabolizing enzymes leading to toxicity.[6]

Pollution is a greater global threat than Ebola and HIV, according to warnings by the World Health Organization. According to its recent report, one in four deaths among children aged under five are now due to environmental hazards such as air pollution and contaminated water. It is simple; poisons in our air and water create oxidative stress, which leads to disease, cancer and death. Epidemiological studies have shown a clear association between cardiovascular morbidity, decreased lung function, increased hospital admissions, mortality, and airborne concentrations of photochemical and particulate pollutants.

Oxidative stress is a by productive of living. We can't breathe or digest food without having a toxic exhaust made of free radicals, which cause oxidative stress. If we have too many free radicals for too long excess oxidative stress leads to inflammation, which leads to all kinds of diseases.

[1] JMAJ 44(12): 535–539, 2001 Noriko NOD and Hiro WAKASUGI.  National Cancer Center Research Institute

[2] Cancer Lett. 2012 Dec 31; 327(0): 48–60. Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

[3] International Journal of Cell Biology. Volume 2012 (2012), Article ID 683897, 16 pages

Electromagnetic Fields, Oxidative Stress, and Neurodegeneration

[4] Collateral Damage in Cancer Chemotherapy: Oxidative Stress in Nontargeted Tissues. DOI: 10.1124/mi.7.3.6 · Source: PubMed

[5] Integr Cancer Ther. 2004 Dec;3(4):294-300. Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness.

[6] Drug Metabolism and Oxidative Stress: Cellular Mechanism and New Therapeutic Insights

Sharmistha Banerjee, Jyotirmoy Ghosh and Parames C Sil. Division of Molecular Medicine


Oxidative Stress and the Immune System


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Manfred Kopf and his team of research scientists have shown that higher doses of antioxidants like vitamin E can reduce the stress on immune cells. Dr. Kopf, a professor at ETH Zurich’s Institute of Molecular Health Sciences, have identified a phenomenon that explains the effects of oxidative stress on immune cells. Whenever a foreign body such as a virus or other pathogen enters our bodies, a certain class of immune cells – the T cells – jump into action, proliferating rapidly. One sub-class of these cells, the CD8+ T cells, eliminate the virus by killing cells it has infected. Other T cells, known as CD4+ T cells, coordinate the immune response to all kinds of pathogens. These are the generals in the immune system’s army.

Immune response does not work efficiently if significant oxidative stress is damaging the T cells. Researchers able to save the immune cells from cell death by mixing high dosages of vitamin E into animals food. We can do the same with hydrogen.

When enough antioxidants, to protect the T cells’ cell membranes from damage, were pumped into rats systems their T cells could multiply and successfully fend off the viral infection. “We are the first to demonstrate that oxidative stress causes immune cells to suffer the same type of death as cancer cells,”Kopf said.


Killing Off the Human Race Slowly With Oxidative Stress


Oxidative stress (OS) has been identified as one of the many mediators of male infertility by causing sperm dysfunction. Excessive production of free radicals or reactive oxygen species (ROS) can damage sperm, and ROS have been extensively studied as one of the mechanisms of infertility. Spermatozoa are sensitive to OS because they lack cytoplasmic defenses (Donnelly et al, 1999Saleh and Agarwal, 2002). No wonder sperm counts are crashing the world over.

Oxidative stress increases significantly when we are physically or emotionally stressed out. This is something to worry about with stress and anxiety going off the charts in the 21st century. One easy way to access this problem is by looking at the quality of our sleep and heart rate variability (HRV), which offers the best measurement of our stress.


Redox Homeostasis


“The health of our body is maintained by the equilibrium of redox control. Redox control means maintaining the balance between active oxygen species and antioxidant enzymes. Excessive external factors can disturb this equilibrium triggering disease and illnesses. Most of the diseases are caused by oxidative stress due to active oxygen, other free radicals and lipid peroxides. Active oxygen, though vital to our body, causes considerable damage to the essential components of human body and disturbs the physiologically important functions of proteins, lipids, enzymes and DNA bearing the genetic code. DNA damage caused by oxidative stress is particularly dangerous and has the potential to lead to serious disorders like cancer,” writes Dr. RD Khanna, Professor Emeritus and Former Head Department of Biophysics, Institute of Medical Sciences at Banaras Hindu University, India.

“Normally about 2% of oxygen inhaled by our respiratory system turns into active oxygen in our body and is used to protect us against external attack from bacteria, germs, viruses and other foreign substances. However, when levels of active oxygen species are increased by tobacco, alcohol, ultra-violet rays, air-pollution, food additives, emotional stress, etc., excessive active oxygen starts attacking not only dangerous substances but also normal functioning cells, damaging proteins, lipids, enzymes and DNA. This state is called oxidative stress. As long as a balance exists between oxidative stress and our antioxidant system, our body is maintained in a healthy state.”[1]

[] Inflammation, Free Radical Damage, Oxidative Stress and Cancer. International Journal of Inflammation, Cancer and Integrative Therapy. Department of Biophysics, Institute of Medical Sciences, Varanasi, India. Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, India   https://www.omicsonline.org/open-access/inflammation-free-radical-damage-oxidative-stress-and-cancer-ijm.1000109.php?aid=32604


Higher Levels of Oxidative Stress than Ever Before


About half of all people with cancer are treated with radiation therapy, either alone or in combination with other types of cancer treatment. Radiation therapy uses ionizing radiation to kill cancer cells and shrink tumors. Americans today receive far more medical radiation than ever before. The average lifetime dose of diagnostic radiation has increased seven-fold since 1980 with doctors and dentists having no real idea of the risks they are taking with their patients’ lives.

Exposure to radiation causes a cascade of free radicals that wreak havoc on the body. Radiation decimates the body’s supply of glutathione, which in turn allows free radicals to run rampant through our body’s tissues and organs. Glutathione is the master antioxidant!


Oxidative Stress and Frequency Pollution


The story only gets worse. In July 2015, a review of existing studies on radiofrequency radiation (RFR) was published by National Academy of Sciences in Ukraine, Indiana University, and the University of Campinas in Brazil. Based on "93 out of 100 peer-reviewed studies, it concluded that low-intensity RFR [radio-frequency radiation] is an expressive oxidative agent for living cells with a high pathogenic potential, and that oxidative stress induced by RFR exposure should be recognized as one of primary mechanisms of biological activity of this kind of radiation. This explains a range of biological/health effects of low-intensity RFR, which includes both cancer and non-cancer pathologies." 

Cellular effects of radiation are basically the same for the different kinds and doses of radiation. The simplest and most direct effect of radiation is cell death. Changes in cellular function can occur at much lower radiation doses than those that cause cell death. Changes can include delays in phases of the mitotic cycle, disrupted cell growth, permeability changes, and changes in motility.


Sulfur, Glutathione & Selenium


Oxyradicals are involved in multiple mutational events and can contribute to the conversion of healthy cells to cancer cells. Glutathione (GSH) and the GSH-replenishing enzymes keep the antioxidant status of normal cells at a level where they can avert oxyradical-derived mutations. When we talk about sulfur pathways and sulfur sufficiency we are at the same time touching on glutathione because glutathione is a sulfur enzyme.[1]

Selenium compounds have been shown to have powerful anticarcinogenic activity. In view of certain similarities between selenium and sulfur biochemistry, scientists tested selenocystamine/cysteamine, semethylselenocysteine/S-methylcysteine and seleno­betaine-sulfobetaine. In these sulfur compounds only cysteamine and S-methylcysteine produced anticancer activity. These sulfur-selenium compounds are active in cancer protection and may have a multi-modal mechanism in preventing cellular transformation as well as in delaying or inhibiting the expression of malignancy after carcinogen exposure.[2]

Garlic also contains selenium, which is crucial for glutathione enzymes.undefined

Glutathione, the most important antioxidant in the body, is that place where sulfur and selenium meet up to protect us from cancer. The immune system cannot function properly without it and antioxidants such as vitamins C and E rely on it to function properly within the body. The glutathione and cancer connection has been well established. Patients with cancer, serious chronic illness, AIDS and over 60 other diseases have reduced glutathione levels. Glutathione plays a specific role in the detoxification of many well-known cancer-causing and cell-damaging substances in our environment.

Japanese study showed that even low concentrations of DMSO (sulfur) had radio-protective effects through the facilitation of DNA double-strand break repair, providing protection against radiation damage at all cellular levels in the whole body.[3] Boosting your body’s antioxidant levels is a key to surviving cancer. DMSO can be used for various medical applications.

[2] Carcinogenesis. 1992 Jul;13(7):1167-70.Comparison of selenium and sulfur analogs in cancer prevention. Ip CGanther HE. Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263


The Perfect Antioxidant


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I am one of the few who have written a comprehensive book on Hydrogen Medicine. Below is some recent research which sustains the conclusions I made in the book, especially as it applies to cancer. Hydrogen is the medicine of the future and should not be ignored by anyone.  

An in vivo study demonstrated that 6 weeks of hydrogen inhalation significantly inhibited tumor growth, as evidenced by decreased mean tumor volume (32.30%) and Ki67 expression (30.00%). Hydrogen treatment decreased the expression of CD34 (74.00%) demonstrating its anti-angiogenesis effects. The in vitro study showed that hydrogen treatment significantly inhibits cancer cell proliferation, invasion, migration and colony formation both in Hs38.T and PA-1 cells. An important finding in this study was that molecular hydrogen could also markedly inhibit sphere-forming ability of both PA-1 and Hs38.T cells.

H2 is a small molecule that can easily dissipate throughout the body and cells; thus, it is be a safe and effective antioxidant for inflammatory diseases and cancer, since ROS usually initiates tumor progression. Treatment with H2 may involve correction of the oxidative/anti-oxidative imbalance and suppression of inflammatory mediators.

There is no toxicity to H2 because the byproduct of the free-radical neutralizing reaction is water. Each molecule of H2 will neutralize 2 hydroxyl radicals into two molecules of H2O hydrating your cells in the process. Hydrogen water at a concentration of 1.6 mg/L would have more “antioxidant” molecules than 100 mg of vitamin C, as there are more total molecules in 1.6 mg of hydrogen compared 100 mg of vitamin C.

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Hydrogen is intriguing. As explained by Tyler LeBaron, founder of the Molecular Hydrogen Foundation, hydrogen powers the sun’s fusion, it is key to ATP production within the mitochondria, and it is the father of all other elements. Hydrogen, along with oxygen, has been intrinsically involved with evolution of life in both prokaryotes and eukaryotes (e.g. hydrogenases, hydrogenosomes, mitochondria, etc.). The extremes of oxygen and hydrogen provide balance between oxidation and reduction, which is vital to life. The most important and basic thing to know about molecular hydrogen is that it negates the toxicity of oxygen.


Antioxidants and Cancer


According to the National Cancer Institute considerable laboratory, evidence from chemical, cell culture, and animal studies indicates that antioxidants may slow or possibly prevent the development of cancer. Antioxidants are nutrients (vitamins and minerals) as well as enzymes (proteins in your body that assist in chemical reactions). They are believed to play a role in preventing the development of such chronic diseases as cancer, heart disease, stroke, Alzheimer’s disease, Rheumatoid arthritis, and cataracts.

The anti-oxidative stress effect of hydrogen was reported to be conferred by direct elimination of hydroxyl radical and peroxynitrite. Subsequent studies indicate that hydrogen activates the Nrf2-Keap1 system. Each molecule of H2 will neutralize 2 hydroxyl radicals into two molecules of H2O hydrating your cells in the process.

Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. H2 selectively reduces the hydroxyl radical, the most cytotoxic of reactive oxygen species (ROS), and effectively protected cells; however, H2 does not react with other ROS, which possess physiological roles. The inhalation of H2 gas markedly suppressed brain injury by buffering the effects of oxidative stress. Thus, H2 can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect against oxidative damage.[1]

ROS are involved in metastatic processes including invasion of cancer cells into surrounding primary tumor sites. Generated ROS regulates tumor progression, indicating that ROS is situated upstream in many signaling pathways including the pathway involved in metastasis. At tumor sites, large amount of ROS are produced by activated neutrophils and macrophages in the inflammatory response.

Hydrogen water erases ROS indispensable for tumor cell growth. Scientists who have studied its antitumor effects used hydrogen in combination with hyperthermia at 42°C and found it to be potent as an anti-tumor agent.[2] Therapeutic opportunities of hydrogen increases in the presence of specific catalysts or heat thus for cancer and other serious diseases it should be used in the context of a full protocol.

[1]  Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals Ikuroh Ohsawa1, Masahiro Ishikawa1, Kumiko Takahashi1, Megumi Watanabe1,2, Kiyomi Nishimaki1, Kumi Yamagata1, Ken-ichiro Katsura2, Yasuo Katayama2, Sadamitsu Asoh1 & Shigeo Ohta1

[2] Oncol Rep. 2010 Dec;24(6):1463-70. Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death. Asada R1, Kageyama KTanaka HMatsui HKimura MSaitoh YMiwa N.


Hydrogen Medicine


Treating cancer with hydrogen, oxygen and carbon dioxide is an approach that treats the fundamental reasons cancer cells form and get aggressive. The sicker a person is the more they will experience the benefits of hydrogen. Hydrogen can be flooded into the body to put out the worst flames of inflammation and oxidative stress. In Hydrogen Medicine we flood the body with the three primary gases—hydrogen, oxygen and carbon dioxide—as a first course of action in all dire medical situations. Same goes for any chronic or acute condition like the flu. The longer one wants to live the more one supplements with these primary gases. The most powerful healing/medical device in the world is a hydrogen oxygen inhaler.


Recent Hydrogen and Cancer Research


“Overall, H2 reduces the risk of life style-related oxidative stress by reacting with strong reactive oxygen/nitrogen species in cell-free reactions. It is easily to apply H2 in cases of oxidative stress, inflammation and tumors. Due to the lack of adverse effects and the high efficacy for the majority of pathogenic statuses involved, H2 gas, H2 water and HS are increasingly being accepted as promising candidates for therapeutic approaches. We hypothesize that H2 gas inhalation and oral administration of H2 water could protect against inflammation in oxidative stress-related cancer, and thus improve the anti-tumor effect in the clinical management of cancer.”

An in vivo study demonstrated that 6 weeks of hydrogen inhalation significantly inhibited tumor growth, as evidenced by decreased mean tumor volume (32.30%) and Ki67 expression (30.00%). Hydrogen treatment decreased the expression of CD34 (74.00%) demonstrating its anti-angiogenesis effects. The in vitro study showed that hydrogen treatment significantly inhibits cancer cell proliferation, invasion, migration and colony formation both in Hs38.T and PA-1 cells. An important finding in this study was that molecular hydrogen could also markedly inhibit sphere-forming ability of both PA-1 and Hs38.T cells.

H2 is a small molecule that can easily dissipate throughout the body and cells; thus, it may be a safe and effective antioxidant for inflammatory diseases and cancer, since ROS usually initiates tumor progression. Treatment with H2 may involve correction of the oxidative/anti-oxidative imbalance and suppression of inflammatory mediators.

“We present the case of a 72-year-old female patient with gallbladder cancer (GBC) who developed in situ recurrence and liver metastases 9 mo after irreversible electroporation ablation and oral tegafur (a fluoropyrimidine derivative) chemotherapy, which failed to control the progression of the disease. The patient further developed metastases in the lymph nodes around the head of the pancreas. The patient had severe anemia, requiring weekly blood transfusions. The gallbladder tumor invaded the descending part of the duodenum, causing intestinal leakage and hepatic colonic adhesion. CASE SUMMARY The patient refused other treatments and began daily hydrogen inhalation therapy. After 1 mo of treatment, the gallbladder and liver tumors continued to progress, and intestinal obstruction occurred. After continuous hydrogen therapy and symptomatic treatments including gastrointestinal decompression and intravenous nutrition support, the intestinal obstruction was gradually relieved. Three months after hydrogen therapy, the metastases in the abdominal cavity gradually reduced in size, her anemia and hypoalbuminemia were corrected, lymphocyte and tumor marker levels returned to normal, and the patient was able to resume normal life. CONCLUSION This is the first report of an efficacy and safety study about hydrogen therapy in patient with metastatic GBC and a critical general condition, who has remained stable for more than 4 months.”