Some scientists believe that the absorptive capacity of healthy skin for substances from the outside is very limited. Nothing can be further from the truth. Most people who have used magnesium oil transdermally experience the reality through quick onset of pain relief. Other medical scientists fear that a successful treatment of magnesium will fail when transdermal magnesium administration is used exclusively. Thus, they cannot yet recommend the application of transdermal magnesium.
Magnesium is necessary for life, so it is important to avail ourselves of every effective method of application. An adequate magnesium supply is important for healthy pregnancy and lactation, as well as in patients with diabetes and prediabetes. Magnesium supplementation is also useful when taking drugs such as diuretics and proton pump inhibitors. All avenues of magnesium administration should be pursued, especially in severe diseases and cancer.
Magnesium chloride and Vitamin C have similar toxicity profiles
with overdose from both resulting at worst usually in
diarrhea unless the kidneys are seriously compromised.
The effectiveness of magnesium supplementation for the treatment of magnesium deficiency is beyond controversy and in critical moments, when our lives are threatened during cardiac arrest, injection and intravenous administration can save a person’s life. Otherwise at home intensive oral treatments can and should be augmented with transdermal use of magnesium through direct application on the skin (massage further increases the efficacy of this treatment) and through hot baths.
One of the most luxurious medical treatments on earth is to receive magnesium massages on a consistent basis. Having at least an ounce of what is called magnesium oil rubbed all over one’s body by a massage therapist, or by a loved one, is simply heavenly. One can also do this oneself, meaning cover one’s body with the magnesium oil, like one would sunscreen, and go out in the sun and have some fun.
Transdermal magnesium application is not the ultimate way to replenish cellular magnesium levels, especially when needing magnesium for constipation or in emergency situations in ICU and emergency centers. However, when applying magnesium directly into the tissues via the skin, magnesium is quickly transported to cells throughout the body, with especial efficacy into the local tissues.
Transdermal absorption of magnesium is effective and presents fewer side effects as it bypasses the gastrointestinal tract. The skin is the largest organ of the body, covering about 1.8 m2 and comprising approximately 10% of the total body mass of an average person. So, we can get quite a bit of magnesium into the body using this large organ. Imagine sitting in a hot bath with kilograms of magnesium (bicarbonate too) trying to pile into the body through every pour and cell on the skins surface.
The concentration of magnesium in pure magnesium oil is about 80,000 mg/l and when you apply that directly on the skin, intake rate is high. But in the case of a bath application my recommendation is for somewhere between 1500 and 5000 mg/l magnesium (1 to 4 times the sea concentration). Dead Sea therapy has a concentration of up to 40,000 mg/l magnesium and people bathe every day in these waters. Fick’s Law of Membrane Permeability says that the amount of any solute (magnesium) that will be absorbed is directly dependent upon the area of contact, the concentration of the solution and the time that the solute is in contact with the membrane.
A recently published study showed that magnesium ions can penetrate the stratum corneum in a concentration and time dependent manner which is significantly facilitated by hair follicles. The first studies on transdermal magnesium absorption was published by the founder of the American Holistic Medical Association Dr. Norman Shealy in 2000. Shealy argued that a magnesium deficiency can be compensated by transdermal application within 4 to 6 weeks, whereas an oral supplementation is effective only after 4 to 12 months.
A study that is cited for proving that transdermal magnesium absorption offers a simple, cost effective and efficient methodology to increase cellular magnesium levels was a trial that took place over a 12-week period and involved a total of nine patients aged between 22 and 69 years. At the end of treatment, a further hair analysis was conducted. After transdermal applications for 12 weeks all patients except one had a significant increase in cellular magnesium ranging from 7.1% to 262%.
A similar study for proving transdermal magnesium absorption is an examination of Waring from the University of Birmingham, United Kingdom, where 19 subjects underwent a full body bath (temperatures 50–55 °C) for 7 days in a solution of magnesium sulphate (Epsom salt) for 12 min. All but three showed a rise in magnesium concentrations in plasma.
Ancient Minerals magnesium products are still my favorite, after a decade of use. I helped them to be the first company to import magnesium oil from the underground Zechstein Sea, where the highest quality of Magnesium in the world is found. Though there are magnesium lotions and bath flakes, it is still the magnesium oil that I use the most because it can be used for all methods of administration.
Each spray of Magnesium Oil contains approximately 18 milligrams of elemental magnesium. An ounce would contain just over 3,300 mg. Five sprays in a glass of water would thus be almost 100 milligrams.Three to five to even ten sprays of magnesium chloride in a glass of pure water or juice is an excellent way to take magnesium internally. It assists digestion, counteracts excess acidity in the stomach, and delivers magnesium swiftly into the bloodstream for distribution to the cells of the body. Minerals like magnesium in ionic liquid form are superior to pill forms. Much more magnesium will get absorbed and absorption will not depend as much on hydrochloric acid levels.
Strong therapeutic foot soaks are another option and are especially important for diabetics who suffer from diabetic neuropathy. Soak the whole body or just the feet in bath water for 20-30 minutes, at a temperature of about 108 degrees. The most effective protocol for this therapy is to begin with a daily body or foot bath every day for the first 7 days, (starting at lighter concentrations and building up) then continue with a maintenance program of 2-3 times a week for 6-8 weeks or longer. Sensitive care must be taken especially with children as to dose levels, water temperature and magnesium concentrations. Muscle spasms might occur on rare occasions if one forgets to get out of the tub, so it is necessary to supervise children and the length of time they remain soaking in magnesium chloride. Any strong reactions like redness in local areas or muscle spasms are indications to reduce concentration.
On page 201 of my Transdermal Magnesium Therapy book I recommend 2-8 oz (56,6 -226,4 g) of Magnesium Oil for a full body bath (ca 100liter) These initial recommendations for baths were very low. My excuse is the inexperience of the early days of transdermal magnesium therapy and also that here in Brazil we don’t have a bathtub so my experience has been with body spraying and magnesium massage. I am now recommending much higher dosages for baths ranging anywhere from 2 to 4 pounds to even six pounds for professional use in clinics and spas.
I am not talking about a nice hot magnesium bath for simple relaxation and general body tonification but professional baths intended for strong therapeutic effect. The % of magnesium in the bath under my old recommendations came only to 45-180 mg/l magnesium. When you discover that open seawater has a content of 1300 mg/l magnesium we see that our early recommendations were way to low. The driving force behind transdermal intake is the concentration gradient.
A third avenue of administration is to simply drink magnesium chloride in ones water or juice. The best way is to combine one of the transdermal routes with oral for concentrated doses that achieve maximum therapeutic effect. Magnesium is important and desperately needed because it is so terribly deficient in people that even at low concentrations people have felt results. But when we are practicing medicine of whatever kind we are looking for dramatic shifts in peoples’ conditions. Below we will have a penetrating discussion about doses and therapeutic effect but the basic idea, when using concentrated nutritional medicines like magnesium chloride, iodine and sodium bicarbonate is to take doses up to maximum levels possible.
Three to five to even ten sprays of magnesium chloride in a glass of pure water or juice is an excellent way to take magnesium internally. It assists digestion, counteracts excess acidity in the stomach, and delivers magnesium swiftly into the bloodstream for distribution to all the cells of the body. Minerals like magnesium in ionic liquid form are vastly superior to pill forms. Much more magnesium will get absorbed and absorption will not depend on hydrochloric acid levels.
Several years ago I told the story of a retired pediatrician Dr. Herbert Mansmann Jr., director of the Magenesium Research Lab who was a diabetic with severe peripheral neuropathy. He was able to reverse the neuropathy and nerve degeneration with a year of using oral magnesium preparations at very high doses. “For example it took me 6 tabs of each of the following every 4 hours, Maginex, MgOxide, Mag-Tab SR and Magonate to get in positive Mg balance. I tell people this not to scare them, but to illustrate how much I needed to saturate myself. Most will only need 10% of this amount (still about three grams). I was doing an experiment on myself to see if it helped my diabetic neuropathy. It worked so I did it for one year, and I have had significant nerve regeneration.”
Dr. Raul Vergin offered the following guidelines for oral intake of a 2.5% Magnesium Chloride hexahydrate (MgCl2-6H2O) solution (i.e.: 25 grams or approximately one ounce of pure food grade powder in a liter of water). The quantity of elemental magnesium contained in a 125 cc dose of the 2.5% solution is around 500 mg.
Dosages are as follows:
Adults and children over 5 years old 125 cc
4 year old children 100 cc
3 year old children 80 cc
1-2 year old children 60 cc
Over 6 months old children 30 cc
Under 6 months old children 15 cc
125 milliliter = 4.2267528 ounce [US, liquid]
cc and ml are equivalent
Dr. Vergin indicates that “In acute diseases the dose is administered every 6 hours (every 3 hours the first two doses if the case is serious); then space every 8 hours and then 12 hours as improvement goes on. After recovery it’s better going on with a dose every 12 hours for some days. As a preventive measure, and as a magnesium supplement, one or two doses a day can be taken indefinitely. Magnesium Chloride, even if it’s an inorganic salt, is very well absorbed and it’s a very good supplemental magnesium source.”
He was taking 20 grams a day but that was because he also had what is called magnesium wasting disease. He thought that about three grams would be sufficient for people without that disorder. When we are going for therapeutic effect with serious disorders like cancer or even autism we want to emulate Dr. Mansmann’s dosage levels.
There are over 200 published clinical studies documenting the need for magnesium and many examples of miraculous “cures” from the use of this common mineral. Yet DAN (Defeat Autism Now) doctors underestimate autistic children’s needs recommending only 50 mgs twice a day in oral form even though children with gut problems can absorb only small percentages through their intestines. The entire autism community needs to be acutely aware that its present dependency on oral magnesium supplementation is responsible for a sizable cause of less then excellent results from chelation. A complete changeover to transdermal/topical approaches to magnesium supplementation is called for with these children because their guts are seriously compromised meaning they cannot absorb magnesium well through oral consumption. Fifty milligrams twice a day is way too low. There is a huge difference between supplementing magnesium and using magnesium chloride as a medicine to effect real and direct changes in overall cell physiology.
 German research have shown Dead Sea salts have ultimately been the reason for reduced amounts of LangerhansA cells in the epidermis, and conversely salts of sodium chloride were void of any effect at all. (al G. S., 1990 December). Magnesium chloride is also discussed when the topic of dermatitis comes into play as an excellent treatment protocol. The anti-inflammatory result of utilizing hypertonic Dead Sea solution on atopic dermatitis by means of magnesium ions is well known. (al., 2002) Further studies also revealed that the magnesium solution greatly reduced inflammation in allergic contact dermatitis. The study involved five patients with an identified nickel allergy, where magnesium chloride (not sodium chloride) stifled nickel-sulfate induced contact dermatitis. (Greiner J, 1990 November)
 Diffusion is the mechanism by which components of a mixture are transported around the mixture by means of random molecular (Brownian) motion (cf. permeation: the ability of a diffusant to pass through a body – dependent on both the diffusion coefficient, D, and the solubility coefficient, S, ie, permeability coefficient, P = D.S). Flynn et al. cite Berthalot as postulating, at the beginning of the nineteenth century, that the flow of mass by diffusion (ie, the flux), across a plane, was proportional to the concentration gradient of the diffusant across that plane. http://www.initium.demon.co.uk/fick.htm
 “I was saturated at about 3 grams of elemental Mg per day, but went to 20 grams for over a year. I now take 5 grams, and stools are semi-formed, and the surrounding water is clear, 3-4 per day.” “Mg is very safe, since the gut absorption is regulated by serum Mg levels, and then the Mg stays in the gut and results in varying degrees of diarrhea. Then the dose is too high. Want soft semi-formed stools. Mine, while on high dosages of magnesium were liquid every 2-4 hours for 2 years, the electrolytes every month were normal, but for low potassium, part of my urinary Mg wasting, both,” wrote Mansmann.
Dr. Mansmann concludes, “I have had diabetic neuropathy for over 10 years. The most significant symptom is my neuropathic pain of burning feet, called erythromelalgia. With the aid of Mg I can completely suppress the symptom, but if my blood glucose level is acutely elevated, because of a dietary indiscretion, the pain flares in spite of an apparent adequate dose of Mg. It goes away with extra Mg gluconate (Magonate) in an hour or so in either case. Without the Mg it will last for six plus hours, even though the blood glucose level is normal in about two hours.” “It is my belief that every one with diabetes should be taking Mg supplementation to the point of one’s Maximum Tolerated Dose, which is until one has soft-semi, formed stools. In addition, anyone with neuropathy, without a known cause, must be adequately evaluated for diabetes and especially those with poorly, slowly, healing foot sores of any kind. Since the use of Mg is safe I see no reason that this should not be “the standard of care”.
So what do we do in the middle of this mess? We turn medicine’s most basic principles upside down. Below is the very beginning of a chapter I published years ago called Beyond Paracelsus. It describes the very heart of pharmaceutical pharmacology. As you read this remember that we are going to create a philosophy and practice of medicine exactly 180 degrees to the opposite. This is no small subject and it would be helpful to understand prerequisite information like the Science of Low Doses meaning that in reality we find that poisons poison people even at ultra low doses. That is what poisons in general do – they poison people, even in minuscule amounts.
While there is no such thing as a safe chemical, it must be realized there
is no chemical that cannot be used safely by limiting the dose or exposure.
Poisons can be safely used and be of benefit to society when used appropriately.
-Royal Society of Chemistry
It is absurd to label pure water as
poisonous simply because one can drown in it.
If someone is having a stroke or heart attack you certainly do not
want to throw them into a bath with four ounces of magnesium inside.
In Natural Allopathic Medicine we assume all poisons have detrimental effect we
only need calculate the total effect from the dose factoring individual sensitivity.
Our cells are best served when they are brimming with magnesium reserves.
Magnesium chloride and Vitamin C have similar toxicity profiles with overdose from both resulting at worst usually in diarrhea unless the kidneys are seriously compromised.