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Hypoxia Supports Tumor Growth and Interferes with Effective Radiation and Chemotherapy

Published on July 24, 2023

Why is modern oncology such a miserable failure? It administers chemo and radiation but pays no attention to the factors that make these toxic medical approaches more effective in saving lives. Cancer treatment success begins with addressing the hypoxic low oxygen levels in the body.

Hypoxia is a state in which oxygen is not available in sufficient amounts at the tissue level to maintain adequate homeostasis; this can result from inadequate oxygen delivery to the tissues either due to low blood supply or low oxygen content in the blood (hypoxemia). Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to an inadequate, and heterogeneous vascular network. It is associated with resistance to radiotherapy and results in a poorer clinical outcome.

Researchers found that an increase of 1.2 metabolic units (oxygen consumption) was related to a decreased risk of cancer death, especially in lung and gastrointestinal cancers, so it behooves us to study hypoxia. There are many reasons, common to large segments of populations, that pull oxygen levels down in cells, with one or two or even more of these reasons present in many if not all who are chronically ill.

Recognition of inadequate oxygen delivery to the cells can be difficult in the early stages because the clinical features are often non-specific but that is no excuse for doctors to not address hypoxic conditions. It’s just too much for the medical establishment to make it easy to diagnose such conditions with the simple use of inexpensive pH paper. Such paper makes it instantly obvious what the oxygen conditions in the body are. This is straight medical science, yet the entire field of medicine ignores pH.

Not sure why anyone would doubt my communications
that oncologists and doctors, in general, are
stupid about
the super importance of magnesium as well as oxygen levels.

The way things are today progressive metabolic acidosis, hyperlactatemia, and falling mixed venous oxygen saturation (SvO2) are not noticed usually until it’s too late and serious disease sets in. In the case of cancer, they don`t usually notice until the patient is dead since they pay absolutely no attention to pH/oxygen conditions at all. Meaning they learn absolutely nothing from all their mistakes and failures. And of course, since their poisonous treatments are highly acidic paying attention to pH/oxygen levels would force them to stop doing what they do.

In all serious disease states, we find a concomitant low oxygen state.
Low oxygen in the body tissues is a sure indicator of disease.
Hypoxia, or lack of oxygen in the tissues, is the
fundamental cause for all degenerative diseases.
Dr. Stephen Levine – Molecular Biologist

Speaking from the perspective of intensive care, Drs. R M Leach, D. F. Treacher say, “Prevention, early identification, and correction of tissue hypoxia are therefore necessary skills in managing the critically ill patient and this requires an understanding of oxygen transport, delivery, and consumption.”[i] This holds true for many acute and chronic medical conditions. Modern oncology obviously is not into medical science only the practice of delivering toxic treatments, so they do know a lot about poisons but do not pay any attention to the toxicity and mineral repletion of the body.

Mineral deficiencies help create hypoxic conditions, especially when they are needed to neutralize chemical and heavy metal toxins. Also, certain minerals are needed by the red blood cells to do their jobs efficiently. A magnesium-deficient diet leads to significant decreases in the concentration of red blood cells (RBC), hemoglobin, and eventually a decrease in whole blood Fe.[ii]

The Heart of Cancer

Dr. Robert Rowan says, “Warburg emphasized that you can’t make a cell ferment unless a LACK OF OXYGEN is involved. In 1955, two American scientists, R.A. Malmgren, and C.C. Flanigan, confirmed Warburg’s findings. They found that oxygen deficiency is ALWAYS present when cancer develops. Warburg found that you can reverse fermentation simply by adding oxygen – but only if you do it early enough. He incubated cells in nitrogen, starving them of oxygen for regular but short periods. Starving the cells of oxygen caused them to begin fermentation. Restoring oxygen promptly enabled the cells to recover. But the longer they were oxygen-starved, the slower and less certain the recovery. With enough oxygen starvation, cells don’t recover. Once they reach a certain point, no amount of oxygen will return them to normal.”

Two papers appearing in the March 13 (2008) issue of the journal Nature confirmed again Warburg’s theories. Led by researchers at Beth Israel Deaconess Medical Centre (BIDMC) and Harvard Medical School, the papers find that the metabolic process that has come to be known as the Warburg effect is essential for tumors’ rapid growth and identifies the M2 form of pyruvate kinase (PKM2), an enzyme involved in sugar metabolism, as an important mechanism behind this process.

Scientists have confirmed many times that long-term lack of oxygen in cells is the key driver of cancer growth. Dr. Ying Xu, Regents-Georgia Research Alliance Eminent Scholar and professor of bioinformatics and computational biology in the Franklin College of Arts and Sciences. His study was published in the Journal of Molecular Cell Biology in 2012. “Cancer drugs try to get to the root—at the molecular level—of a particular mutation, but the cancer often bypasses it,” Xu said. “So, we think that possibly genetic mutations may not be the main driver of cancer.”[iii]

Other Things Oncologists Must Know

The mechanism whereby red cells maintain their biconcave shape has been the subject of numerous studies. One of the critical factors for the maintenance of biconcave shape is the level of red cell adenosine triphosphate (ATP) levels. The interaction of calcium, magnesium, and ATP with membrane structural proteins exerts a significant role in the control of the shape of human red blood cells. Magnesium enhances the binding of oxygen to harem proteins. Magnesium levels drop more slowly in red blood cells than in the serum. Abnormal magnesium-deprived red blood cells lack the flexibility that allows them to enter tiny capillaries.

Though doctors and people do not normally associate iodine with oxygen, we must see that iodine-carrying thyroid hormones are essential for oxygen-based metabolism. First increases of iodine and thyroid hormones increase red blood cell mass and increase the oxygen disassociation from hemoglobin.

Sulfur is required for the proper structure and biological activity of enzymes. If you don’t have enough sulfur in your body, the enzymes cannot function properly. This can cascade into a number of health problems since, without biologically active enzymes, your metabolic processes cannot function properly.

Sulfur enables the transport of oxygen across cell membranes. Because sulfur is directly below oxygen in the periodic table, these elements have similar electron configurations. Sulfur forms many compounds that are analogs of oxygen compounds, and it has a unique action on body tissues.

Conclusion

Hypoxia plays a significant role in influencing anti-cancer immune responses. Hypoxia promotes an immunosuppressive microenvironment by regulating the recruitment of T-cells, myeloid-derived suppressor cells (MDSCs), macrophages, and neutrophils. In addition, hypoxia can have a negative effect on immunogenicity by altering the function of immune cells and/or increasing the resistance of tumor cells to the cytolytic activity of immune effectors.

Cell hypoxia is one of the main causes of free radical generation and oxidative stress leading to inflammation, especially in the capillaries. Capillaries are critical determinants of oxygen and nutrient delivery and utilization so inflammation there is telling.

When acid conditions prevail the oxidative process inside the mitochondria is severely compromised and, it is no surprise, as we switch to alkaline conditions, we find that oxidation is remarkedly facilitated.


[i] https://www.ucl.ac.uk/anaesthesia/StudentsandTrainees/OxygenDeliveryConsumption.pdf

[ii] Influence of magnesium deficiency on the bioavailability and tissue distribution of iron in the rat. The Journal of Nutritional Biochemistry, Volume 11, Issue 2, Pages 103-108

[iii] J. Cui, X. Mao, V. Olman, P. J. Hastings, Y. Xu. Hypoxia and miscoupling between reduced energy efficiency and signaling to cell proliferation drive cancer to grow increasingly faster. Journal of Molecular Cell Biology, 2012; DOI: 10.1093/jmcb/mjs017

Dr. Mark Sircus AC., OMD, DM (P)

Professor of Natural Oncology, Da Vinci Institute of Holistic Medicine
Doctor of Oriental and Pastoral Medicine
Founder of Natural Allopathic Medicine

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