Virtually every cancer patient will benefit from the use of sodium bicarbonate because it treats the low oxygen acid conditions universally found in cancer patients. Sodium bicarbonate shrinks tumors. (Bicarbonate inhibits spontaneous metastases (Robey 2009). ‘Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases’ according to medical scientists. NaHCO3 therapy significantly reduced the formation of hepatic metastases following intrasplenic injection, suggesting that it did inhibit extravasation and colonization.
“Studies conducted at the University of Bari in Italy clearly demonstrated that a hallmark of all tumors, regardless of their origin or background, is their acidic environment. In fact, tumor progression increased with an acidic pH and hypoxia, or a low oxygen level,” writes Dr. Veronique Desaulniers. The perturbation in pH dynamics rises very early in carcinogenesis and is one of the most common patho-physiological hallmarks of tumors.”
“The results of a study suggest that tumor cells do, indeed, perform niche engineering by creating an acidic environment that is non-toxic to the malignant cells but, through its negative effects on normal cells and tissue, promotes local invasion.”
Tumor invasion did not occur into regions with normal or near-normal pH. Immuno-histochemical analyses revealed that cells in the invasive edges expressed the glucose transporter GLUT-1 and the sodium-hydrogen exchanger NHE-1, both of which were associated with peritumoral acidosis. In support of the functional importance of our findings, oral administration of sodium bicarbonate was sufficient to increase peritumoral pH and inhibit tumor growth and local invasion in a preclinical model, supporting the acid-mediated invasion hypothesis.
Increased systemic concentrations of pH buffers leads to reduced intratumoral and peritumoral acidosis. Oral NaHCO3 selectively increased the pH of tumors and reduced the formation of spontaneous metastases in mouse models of metastatic breast cancer. NaHCO3 therapy also reduced the rate of lymph node involvement and significantly reduced the formation of hepatic metastases. Acid pH was shown to increase the release of active cathepsin B, an important matrix remodeling protease.
 Cancer Res 2009;69(6):2260–8