Hydrogen and Inflammation

The scientific research on hydrogen and inflammation is expanding rapidly with scientists finding that lipopolysaccharide (LPS)-induced inflammatory cascades. For the first time, revealed the novel mechanism underlying the inhibitory effect of molecular hydrogen on LPS-caused NLRP3 inflammasome activation, highlighting the promising application of hydrogen as an antioxidant in the treatment of LPS-associated inflammatory pathological damage.[1]

An anti-inflammatory effect of hyperbaric hydrogen on a mouse model of schistosomiasis-associated chronic liver inflammation was reported in 2001.[2]

Hydrogen-rich saline prevents Aβ-induced neuroinflammation and oxidative stress, which may contribute to the improvement of memory dysfunction in animal studies.[3]

Hypoxia is characteristic for sites of inflammation and lesion, and since most people suffer from some sort of inflammation in one part of the body or other, we need to declare inflammation as a main cause of low oxygen levels. Cell hypoxia is one of the main causes of free radical generation and oxidative stress leading to inflammation, especially in the capillaries. Capillaries are critical determinants of oxygen and nutrient delivery and utilization so inflammation there is telling.

[1] Biochim Biophys Acta. 2016 Jan. Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species.


[2] Gharib B, Hanna S, Abdallahi OM, Lepidi H, Gardette B, De Reggi M. Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. C R Acad Sci III. 2001;324(8):719–24.

[3] Brain Research. Volume 1328, 30 April 2010, Pages 152-161