New Breakthrough Cancer Treatment

It turns out that cancer-fighting cells of the immune system can also improve their performance when starved of oxygen, which happens naturally at high altitudes or done at home at seal level with an add on device to an Exercise with Oxygen Therapy system (EWOT). In a study published in Cell Reports, Weizmann Institute of Science researchers have shown that immune system's killer T cells destroy cancerous tumors much more effectively after being starved for oxygen.[1] Oxygen-starved T cells proved much more effective at fighting the cancer.

This special form of EWOT, called Contrast Training, starts with a low oxygen setting (high altitude) and then when the body gets starved for oxygen one flips a switch and an avalanche of oxygen slams into the capillaries forcing oxygen into the cells. "Just as altitude training increases endurance in humans, so putting killer T cells through a 'fitness regimen' apparently toughens them up," says Prof. Guy Shakhar of Weizmann's Institute of Science Immunology Department.

Mountain climbers and endurance athletes are not the only ones to benefit from altitude training -- that is, learning to perform well under low-oxygen conditions.

Freediving competition.

Eleven-time free-diving world champion Goran Colak during a
bout of static apnea; timed breath-holding while immersed in water.

White blood cells respond strongly to altered breathing patterns. We can all voluntarily hold our breath depriving our cells of oxygen. They get hungry for O2 fast but some people, like Freedivers, who dive while holding their breath can hold their breath for over 10 minutes. Scientists at the Norwegian University of Science and Technology used blood samples from elite free-diving athletes to examine how white blood cells of the immune system responds to acute reduction in blood oxygen levels.

They measured total gene expression in the athletes’ white blood cells by a method called full genome microarray analysis. The analysis results were striking: the activity of more than 5000 genes changed in response to the simple effort of breath-holding. This is almost ¼ of all genes found in human cells.

NTNU said, “The most striking finding was a marked increase of the white blood cell type neutrophil granulocytes. These blood cells are programmed for rapid response when the body perceives attacks from intruders; the neutrophils are capable of killing invading cells simply by eating them. But they also have another interesting trait that emerges when oxygen levels drop: neutrophil granulocytes are evolutionary old-timers that stem from an era when the atmosphere contained less oxygen than now, and their modern offspring still prefer environments where the oxygen levels are low.”

We can do EWOT contrast training (costs about two thousand more than a regular EWOT system) and deprive the cells of oxygen and then flood the body’s cells with O2. This will enhance not only the above white cells who thrive on low O2 but also stimulate white blood cell types that use more oxygen – like lymphocytes – which were less active in blood drawn after the athletes held their breath. What was observed are likely to be traces of evolutionary history still embedded in our immune system, visible when oxygen levels change. The study was published in November 2016 in the journal Physiological Genomics.

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Professor Ardenne wrote[2], “Because more than 80% of all cancer deaths are caused by metastases, development and evaluation of methods for fighting tumor dissemination should be major tasks of present cancer research. Formation of metastases is favored by both reduced numbers of immune cells in the bloodstream and impaired oxygen transport into tissues. These closely related signs often emerge concomitantly when the organism is endangered by circulating tumor cells released from the original tumor by therapeutic manipulations. From knowledge of these facts the O2-multistep immune-stimulation technique (EWOT) has been developed as a way of diminishing the risk of tumor spread. The process combines temporary elevation of the number of circulating immune cells with continuous improvement of oxygen transport into tissues.

Otto Warburg established that lactic acid production is a fundamental property of cancer. It is carbon dioxide deficiency that impairs circulation and oxygen delivery to tissues. A lack of exercise leads to lower levels of carbon dioxide and this leads to lower levels of oxygen in the body. That is why cancer patients who exercise have a better prognosis and people stay healthier to begin with when they exercise and why EWOT is so wonderful and powerful in dealing with cancer.

[1] Weizmann Institute of Science. September 18, 2017 Oxygen starvation could toughen up immune T cells for cancer immunotherapy, reports a team of investigators.

[2] Fundamentals of combating cancer metastasis by oxygen multistep immunostimulation processes. von Ardenne M.; Med Hypotheses. 1985 May;17(1):47-65; http://www.ncbi.nlm.nih.gov/pubmed/3892251?ordinalpos=26&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum