Most retailers of sodium thiosulfate do not give recommended dosages for human use in diseases, only for water purification or photography use. Dr. Oleg Yasko in Russia recommends about 1-2 drops twice a week in a cup of tea or water… or if the granular is obtained, only one grain added is recommended. It is potent stuff. If one feels to take more increase dose with caution. It is a known calcium chelator and we are waiting the results of studies to be be more informed of effective doses.