Magnesium

Magnesium plays a critical role in vital DNA repair proteins. Magnesium ions’ synergetic effects on the active site geometry may affect the polymerase closing/opening trends. Distinct structural features of DNA, such as the curvature of dA tracts, are important in the recognition, packaging, and regulation of DNA. Physiologically relevant concentrations of magnesium have been found to enhance the curvature of dA tract DNAs.