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Magnesium & Calcium Protect DNA from Radiation

Published on November 5, 2011

This informal video of physicist and distinguished nuclear expert Dr. Chris Busby has him recommending magnesium and calcium supplementation to everyone concerned about the radiation exposure from Fukushima. Nuclear particles do have a strong propensity to bind with DNA and that is why we see cancers develop, even after low exposure, and that is also why we see drops in fertility and the onset of sterility.

Dr. David Brownstein and I have made a similar universal call for iodine in that the nutritive type of iodine protects the thyroid from the radioactive type of iodine. One has to be a fool not to be taking iodine because 95 percent of us are deficient in iodine, thus making our thyroids sitting ducks (sponges) for the radioactive type. A thyroid deficient in iodine becomes like an intense vacuum cleaner hungry for anything even looking like a halogen (fluoride, bromide, chlorine, rocket fuel). Because so much blood goes through the thyroid it has a fantastic capacity to concentrate radioactive iodine and these halogens no matter how low the concentration is of them in the blood.

Exposure to radiation causes a cascade of free radicals that wreak havoc on the body. Radiation decimates the body’s supply of glutathione.

We are even greater fools though if we are not taking magnesium with an equal amount of calcium (though most often that equal amount of calcium is already supplied by the diet) as the radioactive clouds and rain circle the northern half of the globe. Though I would say the same for iodine and selenium (selenium is not only essential for glutathione production but is also important to take with iodine), magnesium and calcium will protect us and our children from some of the nastiest long-term effects of radiation exposure.

Without sufficient magnesium, the body accumulates toxins and acid residues, degenerates rapidly, and ages prematurely.

“Depleted uranium (DU) is highly toxic to humans, both chemically as a heavy metal and radiological as an alpha particle emitter,” writes Dr. Rosalie Bertell, Canadian Epidemiologist.[1] A new study, conducted by biochemist Dr. Diane Stearns at Northern Arizona University confirms that, separate from any radiation risks, cells exposed to uranium will bond with the metal chemically.[2] Uranium and phosphate have a strong chemical affinity for each other and the DNA and mitochondria are loaded with phosphate so uranium is a DNA and mitochondria deep-penetration bomb.

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Magnesium and DNA


Mechanism of electric conductivity in DNA. Magnesium (silver circles) with no surrounding water supplies holes (light blue circles) to the DNA, which is an insulator. The supplied holes move along the DNA (light blue line).

Magnesium ions play critical roles in many aspects of cellular metabolism. They stabilize structures of proteins, nucleic acids, and cell membranes by binding to the macromolecule’s surface and promote specific structural or catalytic activities of proteins, enzymes, or ribozymes. Magnesium is required as a cofactor for many enzyme systems. It is required for protein synthesis and for both anaerobic and aerobic energy generation and for glycolysis, either indirectly as a part of magnesium-ATP complex, or directly as an enzyme activator. Magnesium has a critical role in cell division. It has been suggested that magnesium is necessary for the maintenance of an adequate supply of nucleotides for the synthesis of RNA and DNA.

Magnesium plays a critical role in vital DNA repair proteins. Magnesium ions’ synergetic effects on the active site geometry may affect the polymerase closing/opening trends.

Distinct structural features of DNA, such as the curvature of dA tracts, are important in the recognition, packaging, and regulation of DNA. Physiologically relevant concentrations of magnesium have been found to enhance the curvature of dA tract DNAs.

Dr. Paul Ellis informs us that, “Magnesium ions are central to the function of the DNA repair proteins, apurinic/apyrimidic endonuclease 1 (Ape1) and polymerase A (Pol A). These proteins are key constituents of the base excision repair (BER) pathway, a process that plays a critical role in preventing the cytotoxic and mutagenic effects of most spontaneous, alkylation, and oxidative DNA damage.”[3]


A DNA polymerase is an enzyme that assists in DNA replication. Such enzymes catalyze the polymerization of deoxyribonucleotides alongside a DNA strand, which they “read” and use as a template. The newly-polymerized molecule is complementary to the template strand and identical to the template’s partner strand. DNA polymerase is considered to be a holoenzyme since it requires a magnesium ion as a co-factor to function properly. DNA-polymerase initiates DNA replication by binding to a piece of single-stranded DNA. This process corrects mistakes in newly-synthesized DNA.

Single-stranded RNA can be highly stabilized by magnesium ions.

The interaction of nucleic acids with magnesium plays an important role in stabilizing their tertiary structure. Site-specific binding of magnesium to nucleotide bases, particularly guanine, has been observed in certain crystal structures. Magnesium, an essential metal that is important in the normal functioning of DNA alters the tumorigenic [tumor-causing] process when it interacts with heavy metals, which are damaging DNA molecules.[4]


The recommended daily allowance (RDA) of calcium is 1,000 mg per day for men and 1,500 mg for women.

A healthy cell has high magnesium and low calcium levels. The higher the calcium level and the lower the magnesium level in the extra-cellular fluid, the harder is it for cells to pump the calcium out. The result is that with low magnesium levels the mitochondria gradually calcify and energy production decreases. Up to 30% of the energy of cells is used to pump calcium out of the cells so we really need to be careful and make sure we are taking enough magnesium.

Magnesium and calcium share a common route of absorption in the intestinal tract and appear to have a mutually suppressive effect on each other. If calcium intake (or dairy intake) is unusually high, calcium will be absorbed in preference to magnesium. Coronary artery calcification is common, severe and significantly associated with ischemic cardiovascular disease in adult end-stage renal disease patients.[5] The amount of calcium in the coronary arteries reliably predicts heart attack risk and is measured by what is called one’s calcium score. UCLA cardiologist, Dr. Matt Budoff, a long-time champion of the Coronary Calcium Scan and author of the AHA paper, says, “The total amount of coronary calcium (Agatston score) predicts coronary disease events beyond standard risk factors.”

Magnesium and calcium work together to control muscle action though calcium becomes increasingly toxic in the face of any kind of magnesium deficiency. Magnesium and calcium are paired minerals and it is vital we take into account the balance between them. Several studies have reported that increasing calcium in the diet significantly reduces the absorption of magnesium. Calcium intakes above 2.6 grams per day may reduce the uptake and utilization of magnesium by the body and excessive calcium intakes increase magnesium requirements. So much stress is placed on the importance of calcium that we may, in fact, be taking in too much and harming magnesium absorption.

According to Dr. Sarah Mayhill, “Calcium and magnesium compete for absorption and so too much calcium in the diet will block magnesium absorption. Our physiological requirement for calcium to magnesium is about 2:1. In dairy products the ratio is 10:1. So, consuming a lot of dairy products will induce a magnesium deficiency.”

Magnesium taken in proper dosages can solve the problem of calcium deficiency. – Dr. Nan Kathryn Fuchs

Another reason Dr. Busby was on solid medical ground in recommending magnesium is that it is also vital in glutathione synthesis. Glutathione synthetase requires ?-glutamyl cysteine, glycine, ATP, and magnesium ions to form glutathione.[6] In magnesium deficiency, the enzyme y-glutamyl transpeptidase is lowered.[7] Data demonstrates a direct action of glutathione both in vivo and in vitro to enhance intracellular magnesium and a clinical linkage between cellular magnesium, GSH/GSSG ratios, and tissue glucose metabolism.[8]


Dr. Busby is correct in his recommendation but he does not have intimate experience with the best way to absorb magnesium into the body. The inexpensive pills available in most pharmacies definitely are not a good way of absorbing these minerals. Absorption rates of solid minerals taken in pill form are not nearly as effective as liquid minerals and there is nothing like transdermal magnesium therapy for effective and quick results. Most peoples’ diets are already too high in calcium and too low in magnesium so it is really the magnesium that needs to be stressed, especially in the first months of supplementation. It takes three or four months of heavy transdermal magnesium therapy with magnesium oil to top off cellular levels of magnesium but a year or more if administration is only given orally. Transdermal applications include direct body spraying, medicinal baths as well as magnesium massage.

[2] A radioisotope of an element will bind best to the same substrates which a non-radioactive isotope of the same element will bind. Dr. Stearns has established that when cells are exposed to uranium, the uranium binds to DNA and the cells acquire mutations, triggering a whole slew of protein replication errors, some of which can lead to various cancers. Stearns’ research, published in the journals Mutagenesis and Molecular Carcinogenesis, confirms what many have suspected for some time – that uranium can damage DNA as a heavy metal, independent of its radioactive properties. The biochemical reaction of heavy metals can cause genetic mutations, which in turn can curtail cell growth and cause cancer. Heavy metals that are also radioactive amplify this effect and can cause distortions in shape and thus function even of red blood cells.


[4] N. A. Littlefield1   , B. S. Hass1, S. J. James1 and L. A. Poirier1(1) U.S. Public Health Service, Food and Drug Administration, National Center for Toxicological Research, Division of Nutritional Toxicology, Department of Health and Human Services, 72079 Jefferson, AR, USA

[5] J Am Coll Cardiol, 2002; 39:695-701. J Am Coll Cardiol, 2002; 39:695-701 American College of Cardiology Foundation.

[6] Virginia Minnich, M. B. Smith, M. J. Brauner, and Philip W. Majerus. Glutathione biosynthesis in human erythrocytes. Department of Internal Medicine, Washington University School of Medicine, J Clin Invest. 1971 March; 50(3): 507–513. Abstract: The two enzymes required for de novo glutathione synthesis, glutamyl cysteine synthetase and glutathione synthetase, have been demonstrated in hemolysates of human erythrocytes. Glutamyl cysteine synthetase requires glutamic acid, cysteine, adenosine triphosphate (ATP), and magnesium ions to form ?-glutamyl cysteine. The activity of this enzyme in hemolysates from 25 normal subjects was 0.43±0.04 ?mole glutamyl cysteine formed per g hemoglobin per min. Glutathione synthetase requires ?-glutamyl cysteine, glycine, ATP, and magnesium ions to form glutathione. The activity of this enzyme in hemolysates from 25 normal subjects was 0.19±0.03 ?mole glutathione formed per g hemoglobin per min. Glutathione synthetase also catalyzes an exchange reaction between glycine and glutathione, but this reaction is not significant under the conditions used for assay of hemolysates. The capacity for erythrocytes to synthesize glutathione exceeds the rate of glutathione turnover by 150-fold, indicating that there is considerable reserve capacity for glutathione synthesis. A patient with erythrocyte glutathione synthetase deficiency has been described. The inability of patients’ extracts to synthesize glutathione is corrected by the addition of pure glutathione synthetase, indicating that there is no inhibitor in the patients’ erythrocytes.  

[7] Braverman, E.R. (with Pfeiffer, C.C.)(1987). The healing nutrients within: Facts, findings and new research on amino acids. New Canaan: Keats Publishing 

[8] Barbagallo, M. et al. Effects of glutathione on red blood cell intracellular magnesium: relation to glucose metabolism. Hypertension. 1999 Jul;34(1):76-82. Institute of Internal Medicine and Geriatrics, University of Palermo, Italy.

# # # #

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Dr. Mark Sircus AC., OMD, DM (P)

Director International Medical Veritas Association
Doctor of Oriental and Pastoral Medicine

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  • frank cardoza

    Remember G. E. has very Deep Pockets

  • frank cardoza

    #Nucleartracktown thanks Dr. (D.S.) Busby great info…bank on it.

  • Felton Nemecek

    Well said!. Will be back later to read more posts. I am bookmarking your feeds also

  • I feel that is among the most important info for me. And i’m happy studying your article. However should commentary on few basic issues, The site taste is ideal, the articles is really excellent : D. Just right process, cheers

  • elvira walker

    Very interesting article. For a year now, I have been trying to find out what is the best ratio of cal to mag, without overdoing either. Please tell me in mg, I do not understand the gram ratio. Thank you

    • Claudia – IMVA Staff

      Dear Elvira,

      Calcium to magnesium ratios should be 1:1 OR 2:1 ratio. So if you take in 200 mg. of magnesium, the balance of calcium would be 200 mg. or at the most 400 mg. Generally it is believed that we take in about 6x more calcium than we need from our diets and enriched foods and juices.

  • Elaine

    We absolutely need daily reminders of this most imoprtant subject. Dr. Mark, again and again, I THANKYOU!!!

    A few years back I had befriended a managerof a GNC store in America. He told me that it was useless to buy the “Glutathione” on the shelves because the molecule is too big to pass through the intestinal wall, and is therefore was waste of money. At that time, I was unaware of the imprtance of Glutathione as it is explained in depth now.
    He also told me that he had a relative who worked for a major drug company.It is one everyone would recognize. Anyway, there was a lot I learned from this person and have no reason to believe he was lying, as it took some time to build up this trust. What he told me was not good news. And this was back around 5+ yrs ago.

    He did however, share with me how important it was to take the “broken cell wall chlorella”, and used it himself.

    I am glad to see so many people waking up and looking for truths beyond the joke called the main stream media.

    Dr. Mark, your website and newsletters are number 1 for me!

    But I am curious to know if you could recommend a glutathione supplement that can get through, and would be of high quality.
    I understand we need the basics for our bodies to make it, but supplementation must certainly help.

    Thankyou again, always!

    • Claudia – IMVA Staff

      Hi Elaine,

      Dr. Sircus recommends suppositories of glutathione as being the most effective, nebulization of buffered glutathione is next most effective and by oral pills is the least effective in our bodies. He has no specific brand that he endorses at this time, but you can get suppositories from a compounding pharmacy. We know of this source for buffered glutathione that can be used for nebulization and is endorsed by Dr. Whitaker:

      • anti_banker

        Doesn’t the body make glutathione from other substaces in our diets and isn’t it a sulfur compound similiar to what is found in eggs and garlic? If we eat enough eggs and garlic I pressume we wouldn’t need glutathione ???

        • Hi anti_banker;

          Please see on website, the many articles on glutathione. You can put glutathione in the search box and come up with a number of them. But one of the most significant things is that if you are magnesium deficient you will lose glutathione needed by our body.
          You can read about that here:
          Adequate selenium is also necessary for glutathione production and so there are a lot of things that will contribute to this….not just sulfur and eggs thought that helps a lot. But other things are needed to keep adequate levels to protect our cells…..
          Cancer, sulfur, garlic and glutathione: From: Disqus
          Sent: Thursday, March 14, 2013 11:00 AM
          Subject: [drsircus] Re: Magnesium & Calcium Protect DNA from Radiation


          A new comment has been posted on Dr. Sircus – International Medical Veritas Association

          On Sunday, Nov. 6th, An unregistered user said:

          Hi Elaine,

          Dr. Sircus recommends suppositories of glutathione as being the most effective, nebulization of buffered glutathione is next most effective and by oral pills is the least effective in our bodies. He has no specific brand that he endorses at this time, but you can get suppositories from a compounding pharmacy. We know of this source for buffered glutathione that can be used for nebulization and is endorsed by Dr. Whitaker:

          On Thursday, March 14th, anti_banker replied:

          Doesn’t the body make glutathione from other substaces in our diets and isn’t it a sulfur compound similiar to what is found in eggs and garlic? If we eat enough eggs and garlic I pressume we wouldn’t need glutathione ???
          Reply on Dr. Sircus – International Medical Veritas Association

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  • OliveOyl

    Thank you so much for all the detail in this article, Dr. Sircus. For those of us who are our own doctors, it really helps to know how these nutrients work together.

  • JJ

    What’s the best way to give babies magnesium?

    Also Iodine frightens me mainly becuase I have Hashimotos so I’m scared it will cause a flare up.
    My oldest daughter hates the mag spray it itches her skin like crazy!

    • OliveOyl

      Hello JJ,

      I’m a reader on several forums which teach iodine usage. Clearly many Hashimoto sufferers are helped by iodine. With Hashi’s, your body may be so low in iodine that it overreacts if you start with a high dosage. The key is to start gently and slowly with topical administration first, then slowly increase it. I would think the nascent iodine would be gentle enough.

      You could suggest to your daughter to dilute the magnesium oil with an equal amount of water. She may find it less itch-inducing. Best of luck with that.

    • Arrow Durfee

      Dr Haskell of Salt Lake City has written a book on the treatment of Hasimoto’s called Hope for Hashimotos, available on Amazon. In it he details the healing protocol for this disease, and yes, iodine is utilized but not right away. Other things are done first to bring the inflammation down. He considers Hashimotos a speciality of his.. I had the pleasure of interviewing him last year and he practices an number of cutting edge alternative modalities.

    • Claudia – IMVA Staff

      Hi JJ,

      One of the best ways to give magnesium to babies is by a magnesium bath. Much easier than trying to get them to swallow it and not near as irritating to their sensitive skin.

      It has been found that the problems that occur when people with Hashimotos take iodine are due to selenium deficiencies. Its important to make sure your selenium intake is adequate, and if it is you are much less likely to have any problems .

      OliveOyl is right, dilute the mag oil with spring water half and half, or have your daughter take baths or foot baths till her tolerance level increases.

      Claudia French

  • Lisa

    Could you please send me information on the best calcium to take, I couldn’t find any recommendations for that. I made not of the transdermal mag, and baking soda…but I have many symptoms of cal def. What do you recommend for that??

    Would appreciate any help you could give.
    Thanks and God Bless