Mitochondrial Medicine

Mitochondria Inside

Dr. Terry Wahls learned how to reverse accelerating multiple sclerosis using an evidence-based, functional medical approach focusing on orthomolecular nutrients and nutrition. Using the lessons she learned at the subcellular level, she used diet to cure her MS and get out of her wheelchair. Her TED talk is quite convincing.

Contemporary medicine has not understood the basics of mitochondrial physiology. Most doctors have no idea why magnesium, bicarbonate, selenium and sulfur are important to the mitochondria. But basic science knows this so it is a wonder that information does not get out about what to do to repair and fire up the mitochondrial energy factories of the cells.

If too many mitochondria fail, there is nothing that can be
done to prevent death. Any successful treatment can
only be to prevent too many mitochondria from failing.

The mitochondria are the power stations of our cells. They are as important to our lives and healths as electrical power stations are to modern civilization. We just cannot get along without them. If mitochondria get severely damaged, they die. If cells lose their mitochondria, they lose their power source, and they die. When enough cells die, we die.

Mitochondria disease is not usually life threatening in an emergency sense. There are few infections that attack the mitochondria though there are poisons like cyanide which will wipe out our energy stations and kill us without much fanfare. The mitochondria are extremely sensitive to heavy metals and general chemical insults. If the mitochondria are denied the basic nutrition they need to function, they cease to function normally.

Dr. Majid Ali says, “Injured mitochondria mutate at much higher rates. Damaged mitochondria are exhausted mitochondria. Exhausted mitochondria cannot produce sufficient ATP molecules. An insufficient supply of ATP molecules means insufficient energy. Insufficient molecular energy means clinical chronic fatigue.” These organelles are the power generators of the cell, converting oxygen and nutrients into ATP (adenosine triphosphate). ATP is the chemical energy "currency" of the cell that powers the cell’s metabolic activities. This process is called aerobic respiration and is the reason animals breathe oxygen.

Mitochondria work by generating an electrical
potential and a pH gradient across that inner membrane.

The mitochondrion is different from other organelles[1] because it has its own DNA and reproduces independently of the cell in which it is found; an apparent case of endosymbiosis.[2] They really are not quite us in the sense that their genetic pool is outside of our own DNA that make us uniquely us. Unlike nuclear DNA, mitochondrial DNA doesn’t get shuffled every generation, so it is presumed to change at a slower rate.

Mitochondria Image

Recent breakthroughs in our understanding of autism and other neurological diseases are coming through mitochondrial research and it is important to note that pharmaceutical drugs are mostly mitochondrial poisons. Mercury is a mitochondrial poison. Data suggest that moderate levels of mercury administered over an 8 week period can affect adversely the integrity of mitochondrial membranes.[3] The field of pediatrics has been perverted by the vaccines and endless antibiotics they have administered to their patients. Pediatricians do the unforgiveable when they inject mercury directly into children’s veins and that is why I wrote and have always given away The Terror of Pediatric Medicine.

“The German cancer researcher Dr. Paul Gerhard Seeger[4] demonstrated in 1938 that in most cases cancer starts in the cytoplasm, the jelly-like outer part of the cell, and especially in the energy-producing mitochondria. Here food fragments are normally oxidized in a series of enzymatic steps called the ‘respiratory chain’. Seeger showed that in cancer cells this respiratory chain was more or less blocked, especially at the site of the important enzyme cytochrome oxidase. Without it the cell can produce energy only anaerobically like a fungal cell. This is very inefficient and the resulting overproduction of lactic acid makes the cell and the whole body overly acidic.

Seeger and others found that cancer cells utilize only between 5 and 50% of the oxygen of normal cells. The virulence of cancer cells is directly proportional to their loss of oxygen utilization, and with this to the degree of blockage of the respiratory chain. In 1957 Seeger successfully transformed normal cells into cancer cells within a few days by introducing chemicals that blocked the respiratory chain.

Seeger’s most important discovery was the certainty that that certain nutrients, mainly from the vegetable kingdom, could restore cellular respiration in low-virulence cancer cells and, with this, transform them back into normal cells.

Seeger’s finding that cancer originates in the cytoplasm and not in the nucleus was confirmed by other researchers. Between 1975 and 1977 they repeated an experiment 93 times in which they replaced the nucleus of a fertilized mouse egg with the nucleus of a cancer cell. In each case the egg developed into a healthy, cancer-free mouse and even the offspring remained cancer-free. Similar results were achieved with frog eggs.

There is increasing evidence that impairment of mitochondrial function, oxidative damage, and inflammation are contributing factors in the pathogenesis of Parkinson’s disease (PD). There is substantial evidence that there is a deficiency of activity of the mitochondrial electron transport chain in PD. Impaired mitochondrial function and activated microglia may both contribute to oxidative damage in PD.[5]

Multiple Sclerosis is the most common inflammatory demyelinating disease of the central nervous system and is the leading cause of non-traumatic neurological disability in young adults. Researchers believe that mitochondria play a key role in chronic axonal loss in this disease. The mitochondria present within the chronically demyelinated axons will be functioning at full capacity for many years but eventually, despite antioxidant defenses, free radical damage will accumulate and mitochondrial function will become compromised. ATP concentration within the axon will decrease and the effect on axonal function will be profound.[6]

Tissue damage in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis is accompanied by the arrest of mitochondrial respiration, loss of mitochondrial DNA, and the expression of nuclear-encoded mitochondrial proteins. Selenium effectively protects colon mitochondria prevented inflammatory and necrotic changes. Selenium in a high dose is therefore a potential therapeutic agent in inflammatory bowel disease.[7]

Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of differences in the mitochondria of normal and cancer cells include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer.

Mitochondrial Electron Transport Chain

Dr. Michael R. Eades says, “As the high-energy electrons are passed along down the inner mitochondrial membrane they occasionally break free. When they break free, they become free radicals. These rogue free radicals can then attack other molecules and damage them. Because these free radicals are loosed within the mitochondria, the closest molecules for them to attack are the fats in the mitochondrial membranes. If enough of these fats are damaged, the membrane ceases to work properly. If enough of the membrane doesn’t work, the entire mitochodrium is compromised and ceases functioning. If enough mitochondria bite the dust, the cell doesn’t work and undergo apoptosis, a kind of cellular suicide. This chronic damage and loss of cells is the basic definition of aging.”

Sulfur is one of the basic elements of life. In fact, sulfur
is the fourth most abundant mineral in the body. The proper
acid alkaline balance of the body cannot be maintained without it.

Sulfur is a main source of antioxidants in the mitochondria. Sulfur has a vital relationship with protein, since sulfur is found in the amino acids methionine, cystine, and cysteine. Thus, these amino acids are known as the sulfur bearing amino acids which are considered the building blocks of protein.

Magnesium Bicarbonate

Magnesium functions as a bicarbonate co-transporter into cells. And bicarbonate acts as a transporter of magnesium into the mitochondria. Magnesium influx is linked with bicarbonate transport according to the Dietary Reference Intakes guide from the Institute of Medicine. Magnesium transport into or out of cells requires the presence of carrier-mediated transport systems. ATPase reaction has a broad pH optimum centering on neutral pH, with little significant activity above pH 9.0 or below pH 5.5. Thus anything that moves us from overall acid conditions toward alkaline that recover the neutral zone is going to enhance cell metabolism via mitochondrial optimization.

If cancer is a mitochondrial disease it can be treated directly with a cocktail of magnesium bicarbonate, sulfur and selenium and it would probably be a good idea to supplement strongly with iodine as well. All of these basic cellular substances will work together to repair damaged cells and their mitochondria and fire them up for full activity.

In the near future it will be magnesium bicarbonate available in concentrated form that is going to turn the world of oncology upside down. It may be a year before production can make this compound in concentrated form widely available to the public. Presently it is available to only a precious few but magnesium bicarbonate water is available in a few bottled waters like Noah’s in California and Unique Water in Australia. Within a few weeks I will be introducing a gravity fed Berkey-type of water filter, which will be the first in the world to produce magnesium bicarbonate water in peoples’ homes.

[1] ORGANELLES mean little organs.  Basically this means that organelles have specific roles to play in how cells Gunther, 1003; Romani et al., 1993work just like organs help the body to function properly as a whole. Some organelles are separated from the rest of the cell by lipid bi-layers similar in structure to the cell membrane.

[2] The endosymbiotic theory concerns the origins of mitochondria and plastids (e.g. chloroplasts), which are organelles of eukaryotic cells. According to this theory, these organelles originated as separate prokaryotic organisms which were taken inside the cell as endosymbionts. Mitochondria developed from proteobacteria (in particular, Rickettsiales or close relatives) and chloroplasts from cyanobacteria.

[3] The effects of mercury ingestion on hepatic mitochondrial membranes of chicks. Poult Sci. 1976 Nov;55(6):2280-4.

[4] The only book available in English is Seeger, P.G. and S. Wolz: Successful biological control of cancer by combat against the causes. Neuwieder Verlagsgesellschaft, Neuwied, Germany 1990. The most important book is Seeger, P.G: Krebs – Problem ohne Ausweg? (“Cancer  – Problem without Solution?”) Verl. f. Medizin Fischer, Heidelberg, Germany 1974, 2nd ed 1988

[6] Mitochondrial dysfunction plays a key role in progressive axonal loss in Multiple Sclerosis. Medical Hypotheses, Volume 64, Issue 4, Pages 669-677 H.Andrews, P.Nichols, D.Bates, D.Turnbull

[7] High selenium diet protects against tnbs-induced acute inflammation, mitochondrial dysfunction, and secondary necrosis in rat colon. TIROSH Oren ; LEVY Eran; REIFEN Ram; Hebrew University of Jerusalem. ISSN 0899-9007  2007, vol. 23, no11-12, pp. 878-886

[8] Gunther, 1003; Romani et al., 1993

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Comments:

  • Ron

    The URL http://www.afibbers.org/wallerwater.pdf returns the following error message:
    Not Found
    The requested URL /wallerwater.pdf was not found on this server.
    Apache/1.3.27 Server at http://www.afibbers.org Port 80

  • Eriks Teteris

    Recipe for Magnesium/Bicarbonate Water Natural mineral waters with high concentrations of magnesium and bicarbonate ions have long been prized for their health promoting qualities. The famous Apollinaris water contains 104 mg/L of magnesium, but unfortunately is also fairly high in sodium and calcium. Mendocino water contains 130 mg/L of magnesium, but again has fairly high calcium and sodium levels. A more ideal water is Noah’s spring water bottled from the Adobe Springs in California. Noah’s California Spring Water contains 110 mg/L of magnesium, but only 3 mg/L of calcium and 5 mg/L of sodium. It also contains 529 mg/L of bicarbonate ions and has a pH of 8.3. Magnesium-rich mineral waters are easily absorbed and have many health benefits due not only to their magnesium content, but also because of their content of bicarbonate ions that help neutralize the carbonic acid formed in the body during metabolic processes. Several studies have shown that an increased intake of bicarbonate may help prevent muscle wasting and bone loss[1-3]. A manufactured magnesium/bicarbonate water, “Unique Water”, has recently been developed in Australia. It contains 120 mg of magnesium and 650 mg of bicarbonate per liter and has a pH of 8.3. Erling Waller, a former afibber, and Jackie Burgess, both frequent contributors to the Bulletin Board, collaborated to develop a recipe for homemade magnesium/bicarbonate water that, in its composition, is very close to both Noah’s California Spring Water and Unique Water. The recipe is based on the reaction of magnesium hydroxide (in milk of magnesia) with plain carbonated water according to the formula Mg(OH)2 + 2CO2 —> Mg(HCO3)2. Plain Milk of Magnesia (MoM) should be used in the recipe. The “active” ingredient should only be magnesium hydroxide [Mg (OH)2], 400 mg per teaspoon (5 ml), and the “inactive” ingredient should only be purified water. 41.7% by weight of magnesium hydroxide is magnesium (Mg), so 5 ml of MoM has 167 mg of Mg, and 1 tablespoon has 500 mg of Mg (1 tablespoon = 15 ml). To prepare the water follow these steps: 1. Chill completely to refrigerator temperature a 1-liter bottle of fully carbonated water. Carbonated waters such as Canada Dry Seltzer, which consist of only water and carbon dioxide (CO2), are suitable. Club sodas such as Schweppes Club Soda are also suitable; they are carbonated water with a small amount of added sodium.
    This is more than strong enough for anyone (trust me). Just adjust how much you use.

    • Ron

      The actual quantity of MoM is not stated for this recipe. It is an assumed that it is 1 tablespoon MoM to 1 liter of carbonated water?

      Kindly clarify, thanks!

      • Eriks Teteris

        Hi Ron, the link that I posted seems to have ‘expired’, so here is another one that I’ve just checked out.
        I got the recipe from mgwater.com

        This also supplies Bicarbonate which is essential to our diets.

        http://www.mgwater.com/bicarb.shtml

        Recipe for Enriching Water with Magnesium Hydroxide:

        FOUR EASY STEPS FOR MAKING THE MAGNESIUM/BICARBONATE DRINKING WATER CALLED “WW”, USING MAGNESIUM HYDROXIDE IN “MILK OF MAGNESIA”, AND CARBON DIOXIDE IN “CARBONATED WATER”

        The chemical formula is Mg(OH)2 + (CO2)2 –> Mg(HCO3)2

        Step 1: CHILL COMPLETELY TO REFRIGERATOR TEMPERATURE A 1 LITER BOTTLE OF “FULLY CARBONATED” WATER. Carbonated waters such as “Canada Dry Seltzer” which consist of only water and carbon dioxide (CO2) are suitable. “Club sodas” such as “Schweppes Club Soda” are also suitable; they are carbonated water with a small amount of added sodium.

        Step 2: SHAKE WELL A BOTTLE OF PLAIN MILK OF MAGNESIA (MoM), THEN MEASURE OUT AS ACCURATELY AS POSSIBLE 3 TBS (45 ml) AND HAVE IT READY. The plastic measuring cup that comes with the MoM is accurate and ideal for the purpose. Use only plain MoM without flavorings, sweeteners, mineral oil, or other additives. The “active ingredient” should be only magnesium hydroxide (Mg(OH)2), 400 mg per teaspoon (5 ml), and the “inactive ingredient” should be only purified water. 41.7% by weight of magnesium hydroxide is magnesium (Mg), so 1 teaspoon of MoM has 167 mg of Mg, and 1 tablespoon (TBS) has 500 mg of Mg (1 TBS = 15 ml).

        Step 3: REMOVE THE BOTTLE OF CARBONATED WATER FROM THE REFRIGERATOR WITHOUT AGITATING IT. REMOVE THE CAP SLOWLY AND CAREFULLY TO MINIMIZE THE LOSS OF CO2. SLOWLY ADD THE PREMEASURED MoM, THEN PROMPTLY REPLACE THE CAP. Next, shake the bottle vigorously for 15 to 30 seconds, making the liquid cloudy. After 1/2 hour or so the liquid will have cleared, and any un-dissolved Mg-hydroxide will have settled to the bottom of the bottle. Again shake the bottle vigorously for 15 to 30 seconds, making the liquid cloudy again. When the liquid again clears all of the Mg hydroxide in the MoM should have reacted with all of the CO2 to become dissolved (ionized) magnesium and bicarbonate. However, if a small amount of un-dissolved Mg hydroxide still remains in the bottom of the bottle as a sediment it may be ignored. This 1 liter of concentrated magnesium bicarbonate water will have 1,500 mg of magnesium and 7,500 mg of bicarbonate. This concentrate must be diluted in order to be “WW”.

        Step 4: DILUTE THIS CONCENTRATE 11:1 TO MAKE DRINKABLE MAGNESIUM/BICARBONATE WATER (WW). To make 4 liters of WW measure and transfer 1/3 liter of the concentrate (333 ml) into a 4 liter container. Fill the container with 3 2/3 liters of plain, preferably purified water. Or, prepare a single glassful of WW by adding 11 ounces of water to 1 ounce of the concentrate. This drinkable water will have approximately 125 mg of Mg and 625 mg of bicarbonate per liter, at pH ~8.3. Other dilutions of the concentrate may of course be made, if so desired.
        shared from :-
        http://www.socialanxietysupport.com/forum/f11/make-your-own-magnesium-bicarbonate-drink-tastes-sweet-46555/
        “Enjoy” :)

        • Eriks Teteris

          The original link that I had for Magnesium Bicarbonate water ‘WW’ water was :-
          http://www.afibbers.org/Wallerwater.pdf

          Maybe someone else can get it to work?

          • Ron

            Hi Eriks,

            Many thanks, I appreciate you taking the time to respond.

            Sei-He-Ki
            Ron

  • Mel

    Am I missing the actual recipe/measurements for the mitochondrial cocktail?

  • Kit

    Is the magnesium water made from milk of magnesia and seltzer a form of magnesium carbonate?

    • http://drsircus.com/ Claudia French

      Hi Kim,

      That is a form of magnesium bicarbonate, but is a weaker form than what is recommended by Dr. Sircus.

      • Kit

        I am taking mag malate and Remag. I can’t get into a bath but I do put a little mag lotion on my arms. Do I need to add the mag bicarbonate?

        • http://drsircus.com/ Claudia French

          We all can benefit from having magnesium in all of our drinking water. Studies have shown that this decreases our risks of heart problems, behavior problems, depression and so many other things. It also protects all of our cells from the toxic assauts of heavy metals and pollution. Dr. Sircus is advising this for everyone.

    • Eriks Teteris

      milk of magnesia (magnesium Hydroxide) + carbonated (fizzy) water then shake to create pressure (that’s the trick) see:- http://www.afibbers.org/wallerwater.pdf