Finally, Safe and Effective Answers to Arterial Plaque and Cholesterol

Want to do a deep cleaning of your blood vessels? Want to suck out that cholesterol gumming up the works? Want to get your life back when you can hardly walk down the block? Want to avoid major and even minor cardio surgery (placement of stents) and, in general, prevent cardiac problems and avoid early and sudden death? What you are going to read about is a new frontier in Atherosclerosis treatment. If you overeat garbage food, this is what you will need, no doubt about it.

If you live a stressful life, this is also for you since stress is one of the fundamental causes of atherosclerosis. Atherosclerotic cardio-cerebrovascular disease (ASCVD) is often caused by chronic stress that causes endothelial injury, directly activating macrophages, promoting foam cell formation, and generating atherosclerotic plaque formation. Chronic stress causes plaque via inflammation, lipid metabolism, endothelial dysfunction, hemodynamics and blood pressure, plaque stability, autophagy, ferroptosis, and cholesterol efflux.

Broken sleep predicts hardened blood vessels. In a diverse sample of over 1,600 individuals, we describe a pathway wherein sleep fragmentation raises inflammatory-related white blood cell counts (neutrophils and monocytes), thereby increasing atherosclerosis severity. So, if you are losing sleep, you must consider treating your vascular plaque.

Magnesium deficiencies do no favors for the blood vessels; almost everyone with chronic disease is magnesium deficient. High blood sugar levels are also toxic to the blood vessel walls; thus, everyone with diabetes and metabolic syndrome should be on the lookout for vascular plaque buildup. Vitamin C deficiency, a soft form of scurvy, is also prevalent for many chronic conditions, including atherosclerosis. The bruising of vessel walls is a case of capillary fragility that requires Vitamin C and collagen. Nearly half of Americans do not get enough Vitamin C.

Epidemiological studies have shown that people who face many stressors—from those who survive natural disasters to those who work long hours—are more likely to develop atherosclerosis, which is the accumulation of fatty plaques inside blood vessels. In addition to fats and cholesterols, the plaques contain calcium, monocytes, and neutrophils, immune cells that cause inflammation in the walls of blood vessels. When the plaques break loose from the walls where they’re lodged, they can cause more extreme blockages elsewhere—leading to a stroke or heart attack.

Atherosclerosis uses cholesterol to provide structure to the plague. Until now, the only drugs to combat this condition are statins and cholesterol-lowering drugs that may slowly reduce plaque over years if combined with strict lifestyle changes. However, these drugs have severe side effects, and they work very slowly, with cardiologists having no faith in Statin drugs’ ability to reverse atherosclerosis. The best they hope for is the stabilization of plaque.

There is no belief system within modern cardiology about curing vascular disease. There is no belief that plaque can be removed entirely. As we shall see below, there are more than several ways to reverse plaque formation in the blood vessels.

We Need Cholesterol

Cholesterol is a lipid molecule that plays a crucial role in various biological processes, including membrane structure, cell signaling, and hormone synthesis. An excess of cholesterol in the blood, they say, can lead to the development of cardiovascular diseases, such as atherosclerosis, which is a leading cause of morbidity and mortality worldwide. That is why statin drugs are so overly prescribed, but in the chapter on statins in Natural Cardiology, it is suggested no one should take them.

The development of plaque is linked to elevated cholesterol levels in the blood. However, it is not the leading cause and does not initiate the process. Plaque buildup leads to different diseases, including coronary heart disease, carotid artery disease, and peripheral artery disease.

Dr. Anita Baxas writes, “Pointing the finger at cholesterol as the cause of heart attacks is one of the most massive and successful marketing coups ever done to get people, including doctors, to believe that cholesterol is a problem. This belief makes billions of dollars a year for the drug industry, the margarine, and the low-fat food industry.”

“There are some facts you need to know in order to understand the role of cholesterol. Firstly, cholesterol is made by the liver. The amount of cholesterol in the body taken in by food is minute compared to what the liver makes. If you lower your cholesterol intake, your liver will just produce more. Lowering cholesterol with dietary intervention is ridiculous. Dietary cholesterol amounts to a maximum of five percent of all cholesterol found in the body. It remains in the body for twenty-four to forty-eight hours, and if dietary cholesterol is restricted, the liver simply makes more cholesterol to meet the needs of the body. As a rule, if the body makes something, it needs it,” continues Dr. Baxas.

More than 40% of adults ages 50 to 64 years in Sweden without known heart disease were found to have some degree of atherosclerosis, according to a new study published in the American Heart Association’s flagship journal Circulation.

Cyclodextrin Rapidly Improves Endothelial Function and Vascular Symptoms

Any safe drug that causes rapid plaque regression in all of the body’s blood vessels will be enormously popular. I am introducing the most significant therapeutic advances in cardiovascular medicine since the introduction of statins, except we are discussing something safe and reasonably easy to administer. Statins have many side effects, including increasing the incidence of both cancer and diabetes.

Therefore, controlling cholesterol levels is paramount for maintaining overall health. However, diminishing the production of necessary cholesterol from the liver with statins does not offer much relief and will not reverse already established plaque.

The best cholesterol control approach uses cyclodextrins (C.D.s), cyclic oligosaccharides composed of glucose units. C.D.s are widely used in research and clinical practice to deplete cholesterol from cellular membranes or to increase the solubility and bioavailability of different pharmaceuticals at local concentrations in the millimolar range.

C.D.s can form inclusion complexes with cholesterol, in which the cholesterol molecule is trapped inside the CD cavity. The interaction between cholesterol and C.D.s has been extensively studied in vitro and in vivo. Cavadex dive bombs right into the vascular plaque and pulls out a cholesterol molecule.

Cavadex treatment of murine atherosclerosis reduced atherosclerotic plaque size and CC load and promoted plaque regression even with a continued cholesterol-rich diet. Cyclodextrins are ingredients in more than 30 different approved medicines and are generally recognized as safe by the U.S. FDA. Cyclodextrins form stable aqueous complexes with other chemicals.

Medical scientists have evidence that simple sugar molecules called 2-hydroxypropyl-β-cyclodextrin increase the solubility of cholesterol and promote its removal. Cyclodextrin is safe and is added to a large number of commercial foods. It is also used to solubilize other drugs for delivery to the body. Since CD treatment in humans is safe and CD beneficially affects key mechanisms of atherogenesis, it may be used clinically to prevent or treat human atherosclerosis.

Cyclodextrins are Cholesterol Scavengers

Cavadex is ring-shaped, with an outside cavity attracted to water and an inside cavity attracted to oils like cholesterol. Users begin to see improvements within just two weeks of treatment, experiencing a rapid onset of biochemical benefits and a slow but steady reduction in plaque volume.

Cyclodextrins are cyclic structures that contain a lipophilic core that has been shown to increase cholesterol solubility, thereby aiding in the regression of atherosclerosis in vitro (Liu et al., 2003; Atger et al., 1997) and in-vivo in murine models (Zimmer et al., 2016).

CD has been extensively used in humans with Niemann Pick type C disease (NPC), a rare genetically inherited disease resulting in the accumulation of cholesterol in tissues due to the inability of intracellular transport, ultimately resulting in neurodegeneration.

“I have taken Cavadex for 45 days. My last blood test was 80 days
previously… My LDL went from 130 to 67, my total cholesterol went from 194 to
142, my triglycerides went from 69 to 40, and my HDL went from 48 to 65.”
Mike T.

CD, first administered IV to humans in 1992, consists of seven glucose molecules bound head-to-tail to form a cone-like structure. The exterior of the cone is water-soluble (hydrophilic; thus, it disperses within the bloodstream), while its interior is fat-soluble.

One molecule of cholesterol fits tightly within the lipid-soluble interior of one CD. One molecule of CD can “pluck” one cholesterol molecule from the cell membrane surrounding a vascular cell. From there, the cholesterol-loaded CD can be excreted in the urine, or CD can transfer its cargo (a single cholesterol molecule) to HDL (HDL can house 100s of cholesterol molecules). CD acts as a “shuttle” and HDL as a “sink,” a high-capacity cholesterol acceptor in this fashion.

The rapid resolution of angina symptoms has been reported by a cardiologist in a U.S. Mid West Clinic. Twenty patients with active angina were treated with Cavadex using rectal administration. A marked improvement or resolution of angina occurred in 18 (90%) compared with an expected spontaneous improvement of about 10% (Ghandi et al).

Cavadex was administered to our first patient at our Melbourne clinic in April 2019, and within four weeks, the plaque was reduced. Cavadex circulates around the cardiovascular system, removing built-up cholesterol and plaque and significantly reducing plaque. The secret, though, is to administer Cavadex intravenously or at home via convenient liquid suppositories. It is destroyed in the gut and has no effect if taken orally.

A recent study by the University Hospital in Bonn, Germany, discovered that cyclodextrin melts away cholesterol crystals (the leading cause of arterial plaque that clogs arteries) and reduces existing plaque within four weeks.

Another study by the University of Texas Southwestern Medical Center, Dallas, Texas, shows the treatment of Npc1-deficient mice slows cholesterol sequestration in major organs and improves liver function. This study indicates that cyclodextrin effectively mobilizes entrapped cholesterol in late-stage NPC disease, improving liver function.

Australian biopharmaceutical company Cholrem has produced CAVADEX (Beta-Cyclodextrin). Cholrem CEO Kyle Hodgetts said: “I developed this treatment to save my own life. After the first month of treatment, my cholesterol levels were dramatically reduced. There was a substantial improvement in my liver function, and within another month, CAVADEX significantly reduced the blockages in my arteries.”

Professor Laurie Howes, a researcher in preventative cardiology and pharmacology, commented: “I have managed Kyle’s cardiovascular problems over at least ten years; we have had disagreements about his management and especially his lifestyle. Conventional cholesterol treatments and lifestyle changes can reverse blockages in arteries, but it is a slow process over many years. I have never seen such dramatic effects and results over a matter of months.”

Other Forms of Plaque Relief

Plaquex IV therapy is a form of intravenous therapy that involves the administration of a compound medicine, phosphatidylcholine (P.C.), to improve circulation and promote overall vascular health. The P.C. complex used in Plaquex therapy IV is derived from soybean lecithin and contains a high concentration of polyunsaturated fatty acids (PUFAs), such as linoleic and linolenic acids.

Plaquex has been studied in many countries since the 1950s. Plaquex is used to treat atherosclerosis. It is given to patients suffering from angina pectoris, whose coronary arteries contain plaque deposits, and to patients with carotid artery plaque and peripheral plaque in the legs, causing claudication pain when walking.

It is administered by infusion with a venous catheter for 90 minutes. A minimum of 20-40 Plaquex infusions is suggested. In severe cases of heart disease (Bypass and Angioplasty candidates), up to 45 or more treatments with Plaquex may be required. The great advantage of Cavadex (Cyclodextrins) is that it can be done at home using liquid suppositories.

In other chapters of Natural Cardiology (a new book in progress), we will explore different methods, including chlorine dioxide, DMSO, hydrogen, oxygen, and carbon dioxide inhalation, as well as various enzymes that can help clear the vessels from plaque deposits and reduce the chances of cardiac arrest when the plaque gets out of hand.