Post-Acute COVID-19 Vaccination Syndrome and Metabolic Failure

A recent review paper published in Hormone and Metabolic Research offers a possible explanation for the persistent fatigue reported by some individuals following COVID-19 vaccination, often described as Post-Acute COVID-19 Vaccination Syndrome (PACVS). According to the authors, the core problem may involve disturbances in the body’s energy metabolism rather than a purely psychological or nonspecific reaction.

The Independent Medical Alliance reports:

“For millions living with long COVID or PACVS, exhaustion is a constant biological reality. An estimated 10% of individuals infected with SARS-CoV-2 develop persistent long-term symptoms, while PACVS has been reported in 0.2–0.9% of vaccine administrations, according to pharmacovigilance analyses. For both groups, the hallmark triad of fatigue, brain fog, and post-exertional malaise can make even routine physical activity impossible.”

“Standard tests often come back normal. But a new peer-reviewed review now explains what’s happening at the metabolic level, and maps a framework for recovery.”

“Published in Hormone and Metabolic Research (Thieme), the review by Carlos Gracidas, Rakeem Levy, Dr. Joseph Varon, and Matthew Halma identifies three interconnected ways that energy metabolism goes wrong in long COVID patients, and makes the case that the same framework applies to PACVS: fat oxidation, carbon dioxide balance, and lactate handling. Together, these disruptions help explain why something as simple as a short walk can leave patients completely wiped out.”

The review summarizes findings from exercise testing, metabolic studies, and laboratory analyses, suggesting that affected patients exhibit impaired cellular energy production. In particular, researchers describe three overlapping disruptions: reduced ability to burn fat efficiently as fuel, early buildup of lactate during physical activity, and altered carbon dioxide regulation that interferes with oxygen delivery to tissues. Together, these factors may create a state of “metabolic insufficiency,” in which even minor exertion leads to disproportionate exhaustion.

Under normal conditions, the body flexibly shifts between energy sources and maintains a stable balance of oxygen and carbon dioxide to support mitochondrial function. In the proposed model, this flexibility is compromised. Patients appear to reach anaerobic metabolism more quickly during activity, meaning they generate lactate at lower levels of exertion than expected. This may explain why everyday tasks can trigger prolonged fatigue in some individuals.

The review does not claim that all post-vaccination symptoms share a single cause, nor does it establish definitive mechanisms. However, it suggests that measurable changes in energy metabolism may underlie at least part of the fatigue experienced by certain patients. Further research will be required to determine prevalence, causation, and appropriate therapeutic strategies.

When mitochondria are damaged by spike protein exposure,
fat burning drops, lactate builds up too early, and CO₂
levels fall, creating a vicious cycle of chronic energy failure.

Major medical regulatory bodies do not recognize PACVS as a distinct, defined syndrome because they really do not want to admit the absolute horror of mRNA injections. However, serious adverse events such as myocarditis, pericarditis, and thrombosis with thrombocytopenia have been acknowledged and studied. But they hide behind the rare word, making modern medicine into a tragedy. The worst thing in modern medical history is the COVID genetic injections, and no matter how many people have been hurt by them, they will not remove them from the market. We can not have doctors, nurses, and politicians recognized as killers, can we?

It is said that 90% of doctors have taken mRNA injections, and many are suffering and even dying from it. It is like doctors have blinded themselves, not deliberately, but their medical training put blinders on them, as race horses have, so they can only see one way, the way of pharmaceutical madness.

And medical boards everywhere make sure doctors don’t take off their blinders, or they get excommunicated from their profession. And when anyone, especially AI, talks about major regulatory bodies CDC, EMA (European Medicines Agency), WHO, FDA, or any other major medical organization it is a case of the blind leading the blind. These organizations lie so much and so often about so many things; there is little wonder that modern medicine is bleeding trust like a nearly dead man bleeds out.

Interference at the Genetic Signaling Level Carries Long-term Risk

Dr. Peter McCullough’s Recommendations

Pathophysiological evidence increasingly implicates the Spike protein in endothelial injury, neuroinflammation, and microclot formation long after viral clearance or mRNA-based vaccination. In this context, Dr. Peter McCullough’s Base Spike Detoxification Protocol provides an integrative biochemical rationale for mitigating residual spike protein toxicity. This protocol—comprising nattokinase, bromelain, and curcumin—targets proteolytic spike degradation, fibrinolysis, and inflammation. However, many patients with long COVID continue to suffer from debilitating fatigue, brain fog, pain, and dysautonomia despite ongoing enzymatic detoxification.

Adding Low-Dose Naltrexone (LDN) to this regimen represents a logical step forward in comprehensive management. LDN, typically administered at doses of 1.5-6 mg daily, acts as a glial modulator and immunoregulator.

Dr. Sircus’s Recommendations

I hope you noticed that doctors from the Independent Medical Alliance pointed out deficiencies in carbon dioxide, which is alarming because modern medicine has the bad habit of ignoring carbon dioxide and bicarbonate therapies, meaning protocols that lack these vital CO2-raising therapies are feeble.

In healthy individuals, lactate (a byproduct of anaerobic energy production) only builds up at higher exercise intensities. In long COVID patients, this threshold arrives far too early. Even low-level activities like walking can trigger the “burning” sensation and fatigue most people associate with intense exercise, despite normal heart and lung function on standard tests. Bicarbonate and CO2 therapies neutralize lactate in COVID and cancer patients.

The Independent Medical Alliance confirms, “Poor fat oxidation forces more reliance on glucose, which produces more lactate. Low CO₂ levels mean less oxygen reaches tissues, pushing the body further into anaerobic metabolism. Each disruption amplifies the others. Sodium bicarbonate supplementation: one study showed a 26% increase in lactate threshold.”

Blood clots have emerged as a common factor underlying many COVID-19 symptoms. Researchers in Germany have discovered that the virus changes the size and stiffness of red and white blood cells in the human body. Moreover, these changes can last for months, possibly explaining the seemingly never-ending symptoms of COVID-19.

COVID-19 vaccines can destroy any cell that manufactures the SARS-CoV-2 spike protein, particularly in the circulation. If that happens to the endothelium, the cell layer that lines the inner surfaces of our blood vessels, those vessels may begin to leak, and clots will form. Given that 2021 research showed the spike protein entering the bloodstream shortly after vaccination, this dangerous endothelial involvement in spike protein production is highly likely and expected.

Chlorine dioxide prevents spike proteins from binding to ACE2 receptors on blood vessels, so this small substance applies to COVID infections and the damage caused by the spike proteins that the COVID vaccines command the body to make.

There have been many proposed treatments for COVID infections, from Ivermectin to zinc, antibiotics, steroids, hydroxychloroquine, iodine, vitamin C and D, and even nebulized sodium bicarbonate, with success in ICU COVID patients. These things will help, some enormously, but hospitals (death camps) prefer medicines like Remdesivir, which increased patients’ chance of death significantly.

But just about everyone ignores chlorine dioxide except dentists and public water experts, probably because of the pharmaceutical conspiracy that made it illegal to treat disease in every country except one, where it was successfully deployed during the COVID outbreak and stopped COVID in its tracks. Chlorine dioxide and carbon dioxide inhalation therapy, and even baking soda, should be at the top of the list to treat complications from the so-called virus (bioweapon) and from the even worse mRNA vaccines.

And of course, doctors are insane to leave out magnesium from their protocols because treating magnesium-deficient patients without magnesium compromises all other treatments. And of course, practicing breathing retraining can only help raise CO2 levels, but that is over the long haul; use bicarbonates for instant results.

Conclusion

Widely accepted side effects and negative consequences of mRNA shots:

Injection site pain
Injection site redness
Injection site swelling
Fatigue
Headache
Fever
Chills
Muscle pain (myalgia)
Joint pain (arthralgia)
Nausea
Vomiting
Diarrhea
Swollen lymph nodes (lymphadenopathy)
Anaphylaxis
Myocarditis
Pericarditis
Arrhythmias
Acute coronary syndrome
Bell’s palsy
Guillain-Barré syndrome
Multisystem inflammatory syndrome
Thrombocytopenia
Immune thrombocytopenia
Menstrual irregularities
Allergic reactions
Dizziness
Syncope
Chest pain
Shortness of breath
Rash
Urticaria
Facial swelling
Death

It is important to remember that COVID was a gain-of-function bioweapon. All available evidence strongly supports the conclusion that SARS-CoV-2 was a laboratory-engineered pathogen. Multiple intelligence agencies will testify to that, but the press and government not only still hide as much as possible that fact but refuse to arrest, jail, and hang the guilty parties for mass murder.

And to top it all off, mRNA COVID-19 vaccines were another bioweapon designed to neutralize the bioweapon pathogen, making it impossible to ascertain which bioweapon was worse. Without differentiating between the two types of bioweapons, it is conceded that millions died and many millions more are suffering from long COVID and from Post-Acute COVID-19 Vaccination Syndrome.