Hydrogen as an Anti-Atherosclerotic Agent Combined with Magnesium

In addition to magnesium, hydrogen therapy has emerged recently as a novel treatment approach to reduce oxidative stress and inflammation. Molecular hydrogen (H2) is an inert, tiny molecule that can diffuse quickly into tissues and cells. Remarkably, H2 has been found to have antioxidant and cell-signaling properties with therapeutic benefits. Research since 2007 (when the antioxidant effects of H2 in a medical context were first clearly demonstrated) shows that hydrogen can protect cells by selectively neutralizing the most harmful reactive oxygen species, notably the hydroxyl radical (OH) and peroxynitrite, without disturbing beneficial signaling oxidants like hydrogen peroxide.

Additionally, rather than acting as a conventional antioxidant that donates electrons, H2 triggers adaptive responses in the body. It induces a hormetic effect by activating the Nrf2 pathway, which upregulates the body’s antioxidant enzymes (like glutathione peroxidase, superoxide dismutase, etc.)

Hydrogen also modulates cellular signaling pathways associated with inflammation – studies indicate it can inhibit the pro-inflammatory NF-κB pathway and downregulate excessive cytokine release, interfering with the NLRP3 inflammasome activation that drives inflammation.

While distinct, Magnesium and hydrogen therapy converge on similar therapeutic targets – chiefly, the reduction of oxidative stress, the support of mitochondrial function, and the damping of chronic inflammation.

Both magnesium and hydrogen play roles in managing oxidative stress, but from different angles. Magnesium sufficiency helps prevent the excessive generation of ROS in the first place: when magnesium is low, cells can become destabilized, leading to mitochondrial dysfunction and activation of stress pathways that produce free radicals.

Magnesium deficiency enhances oxidative stress via elevated NADPH oxidase activity and impaired antioxidant defenses (partly because some enzymes require magnesium). Correcting magnesium deficiency can lower baseline oxidative stress and improve the redox balance. Hydrogen, conversely, directly neutralizes specific ROS and augments the antioxidant system. H2 will selectively eliminate the most reactive oxidants (like ·OH) that magnesium-driven enzymes cannot neutralize.

Therefore, in a scenario of oxidative stress, magnesium and hydrogen could offer a one-two punch: magnesium repletion removes the trigger for ROS overproduction, and hydrogen therapy removes excess ROS and prevents oxidative damage. This complementary effect can be especially relevant in conditions like ischemia-reperfusion injury, metabolic syndrome, or neurodegeneration, where oxidative stress is high.

Mitochondrial Function: Magnesium is indispensable for mitochondrial ATP production – it activates enzymes in oxidative phosphorylation and is required for ATP synthase function. Without adequate Mg2+, mitochondria generate less ATP and may leak more electrons (contributing to ROS formation). Chronic magnesium deficiency can even lead to structural and functional mitochondrial damage. Magnesium deficiency and excess oxidative stress affect vascular tissues and the heart.

Hydrogen’s mitochondrial benefit is to protect these organelles from oxidative insult and to promote mitochondrial quality control. By scavenging radicals inside mitochondria, H2 prevents damage to mitochondrial membranes and DNA. Moreover, hydrogen has been shown to induce mitochondrial biogenesis and improve mitochondrial efficiency through cell signaling effects.

Therefore, magnesium and hydrogen support mitochondria in complementary ways: magnesium ensures the enzymes and energy machinery function properly, while hydrogen keeps the mitochondrial environment clean of excessive ROS and may even stimulate the production of new, healthy mitochondria. Improved mitochondrial function translates into better cellular energy availability and resilience, which is beneficial in virtually all tissues—from heart muscle (which demands constant high ATP) to brain neurons (which are highly sensitive to energy deficits and oxidative damage).

Clinical experiments have observed that hydrogen-rich water or inhalation can lower markers of inflammation in patients with rheumatoid arthritis and metabolic syndrome. Magnesium therapy removes the underlying cause of inflammation (magnesium deficit), while hydrogen therapy directly intervenes in the inflammatory cascade. An illustrative example is cardiovascular health: magnesium deficiency contributes to hypertension and endothelial inflammation; repleting magnesium can lower blood pressure and improve endothelial function, while hydrogen (by reducing oxidative stress in vessels) can further protect the endothelium and reduce vascular inflammation. The combined effect could synergistically improve outcomes in diseases like atherosclerosis or heart failure, where inflammation and oxidative stress are intertwined.

Given these complementary actions, researchers and integrative medicine practitioners have started to explore using magnesium and hydrogen in tandem. From a scientific perspective, dual magnesium and hydrogen therapy is more than plausible: Magnesium addresses cells’ upstream metabolic and micronutrient needs, while hydrogen addresses downstream damage control and signaling modulation. Both ultimately improve the body’s redox state and metabolic efficiency.

Notably, both therapies are considered relatively safe and have mild side effect profiles, making their combination agreeable. Unfortunately, most studies have looked at either magnesium or hydrogen supplementation in isolation. What is clear is that magnesium and hydrogen therapies share a common theme of restoring cellular balance. Oxidative stress and inflammation are the final common pathways in many chronic diseases, and magnesium and hydrogen each provide pieces of strategy to combat those processes.

For Cardiovascular Disease

Oxidative stress and inflammation are closely related to atherosclerotic cardiovascular disease. Atherosclerotic plaque vulnerability is a vital clinical problem as vulnerable plaques tend to rupture, which results in atherosclerosis complications—myocardial infarctions and subsequent cardiovascular deaths. Hydrogen has been shown to attenuate the development of atherosclerosis in mouse models. In addition, Hydrogen significantly enhanced plaque stability by increasing collagen levels and reducing macrophage and lipid levels in plaques.

The decreased numbers of dendritic cells and increased numbers of regulatory T cells in plaques further supported the stabilizing effect of hydrogen. Moreover, hydrogen treatments decreased serum ox-LDL levels and apoptosis in plaques with concomitant inhibition of endoplasmic reticulum stress (ERS) and reduction of reactive oxygen species (ROS) accumulation in the aorta.

Vulnerable plaques contain monocytes, macrophages, and T-cells. The inhibitory effects of Hydrogen on the apoptosis of macrophage-derived foam cells, which take effect by suppressing the activation of the ERS pathway and activating the Nrf2 antioxidant pathway, lead to an improvement in atherosclerotic plaque stability.

Given our current understanding of its role as a small-molecule antioxidant and anti-inflammatory agent, hydrogen seems vital in preventing and treating atherosclerotic cardiovascular and cerebrovascular diseases. In the past decade, more than 50 publications in the English language literature considered the role of Hydrogen as an anti-atherosclerotic agent.

Hydrogen has many required characteristics for a successful vascular neuroprotectant: it is easy to produce, diffuses rapidly through the lipid membranes, is inert and safe to administer, and reacts only with the most aggressive ROS. Hydrogen gas eliminates hydroxyl free radicals and peroxynitrite anions, producing a therapeutic effect in patients with ischemic stroke. Many studies have illustrated hydrogen’s antioxidative, anti-inflammatory, and anti-apoptotic effects.

Is Hydrogen Medicine for You?

A new study in a large animal model published in the journal JACC: Basic to Translational Medicine suggests that adding Hydrogen to the usual mix of respiratory gases could protect babies’ brains during open-heart surgery with cardiopulmonary bypass, which carries a risk of damaging the brain.

John Kheir, MD, a cardiologist in Boston Children’s Hospital’s Cardiac Intensive Care Unit and a professor at Harvard Medical School, thinks Hydrogen can easily be incorporated into clinical workflows. Kheir believes many patients at risk for brain hypoxia could benefit from Hydrogen, including infants undergoing congenital heart surgery or those suffering a stroke, cardiac arrest, or pneumonia.

“During the reperfusion process, the cell mitochondria overreact and use oxygen to injure themselves. The body tries to scavenge these chemicals, but when the damage is severe, the scavenging system is overwhelmed, and tissues are injured. When this occurs in the brain, it can cause neurologic impairment,” writes Kheir.

Hydrogen enters cells quickly and reacts harmlessly with oxygen molecules, forming water. That is the easiest way to see why hydrogen hydrates to the point where it quickly brings down dangerous oxidative stress and inflammation. In addition, studies in Japan show how Hydrogen may protect the brain during oxygen loss. Hydrogen gas is so fast acting that we read scientific articles saying, “H2 gas inhalation delays the progression to irreversible shock. Clinically, H2 gas inhalation is expected to stabilize the subject until curative treatment can be performed, thereby increasing the probability of survival after hemorrhagic shock.”

The same can be said about the lungs. Hemorrhagic shock followed by fluid resuscitation (HS/R) triggers an inflammatory response and causes pulmonary inflammation that can lead to acute lung injury. Hydrogen, administered through inhalation, exerts potent therapeutic effects against acute lung injury induced by fluid resuscitation and attenuates the activation of inflammatory cascades.

However, you do not have to be dying of cancer or be threatened with brain inflammation. Genita M. Mason, the Medical Director at The Biosanctuary, writes, “My patients and myself have experienced what I would call miraculous results if I did not understand the science behind what is happening “under the hood.” Fatigue, brain fog, visual issues, depression, anxiety, low hormones, athletic endurance, neurodegenerative disease, cancer, cardiovascular disease, diabetes, biotoxin illness, all gut issues – essentially every condition we have treated after implementing hydrogen inhalation to the program has dramatically improved or completely cleared.”

Hydrogen tends to lift all boats, medically speaking. We can do many things for our health, but hydrogen, oxygen, and carbon dioxide provide essential backbone treatments that will do wonders for your life if you can afford them. I recommend hydrogen machines whose output is 66% hydrogen and 33% oxygen (HHO), slow breathing, and bicarbonates mixed with magnesium as fundamental treatments.

Hydrogen Rescues COVID Vaccine Vascular Damage and Inflammation?

Scientists in Japan have found that inhaling hydrogen gas attenuates vascular remodeling by reducing oxidative stress. If used over a long period, constitutive inhalation of hydrogen gas could help prevent vascular diseases such as atherosclerosis.

Vascular remodeling is a complex and fancy medical concept explaining vascular tissue changes. The vessel wall is an active, integrated organ composed of endothelial, smooth muscle, and fibroblast cells coupled in a complex autocrine-paracrine set of interactions. The vasculature can sense changes within its milieu and change through the local production of mediators that influence structure and function. Vascular remodeling is an active process of structural alteration that involves changes in at least four cellular processes — cell growth, cell death, cell migration, and production or degradation of the extracellular matrix.

This book makes me one of the leading experts on Hydrogen Medicine because I define and combine hydrogen, oxygen, and CO2 gases. Most people skip over the use of carbon dioxide as a medicine.

For emergency rooms, ICU centers, ambulances, and even for sideline medical support for contact sports in case of concussions, here is a new price-breaking 3 liter a minute hydrogen/oxygen inhalation machine (Brown’s Gas 66% H2 & 33% O2) for 3,700,00 dollars including DHL freight, which is less expensive than some far less powerful machines. For at-home use, it is powerful enough for two people to use together and is the only machine on the market with automatic water intake and drainage available. Meaning it is the easiest machine to use one can get.

https://hydroproducts.info/