Introduction
SECTION - Causes and Characteristics of Cancer - Part 1
INTRODUCTION TO TREATMENTS
Causes and Characteristics of Cancer - Part 2
CHELATION
Hydrogen Medicine
Magnesium Medicine
Bicarbonate Medicine
Iodine Medicine
SELENIUM MEDICINE
Diets, Fasting and Super-Nutrition
CO2, Cancer and Breathing
Oxygen Therapy for Cancer Patients
Cannabis Medicine
Final Considerations

Lesson 10 – Inflammation as a Basic Cause and Characteristic of Cancer

Inflammation_INF0118_cover

In Latin, the word "inflammation" means "ignite, set alight" and like gasoline, that's exactly what it does for cancer. A micro-environment of chronic inflammation sets the stage for cancer. Inflammation increases chemotherapy resistance and turn on oncogenes, genes that can turn cells into tumors. Inflammation promotes the spreading and mutating of cancer cells while continuing to push the mutations within the cancer cells' development. Inflammation also enhances tumors ability to recruit blood supply (angiogenesis). Changes catalyzed by pathogenic inflammation can transform cells into cancerous tumors. Cancer is caused by inflammation and is an inflammation causing more inflammation.

Chronic inflammation may be a causative factor in a variety of cancers. In general, the longer the inflammation persists, the higher the risk of cancer. At the basement of life inflammation is inseparable from lower pH, lower oxygen and CO2 levels and low cell energy. With inflammation we have hordes of viral, bacterial and fungal sharks ready to start biting on tissues. We have acid conditions created anytime we get into low oxygen so actually the best way of moving the body towards a more alkaline condition is to increase oxygen and CO2 levels simultaneously.

A MIT study offers a comprehensive look at chemical and genetic changes that occur as inflammation progresses to cancer. “Inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.”

“All types of inflammation can cause cancer. Lung cancer can be caused by chronic smoke-induced inflammation. Esophageal cancer can be caused by acid reflux-induced inflammation. Stomach cancer can be caused by H. pylori (the bacterium that causes ulcers)-induced inflammation. Bladder cancer can be caused by urinary tract infection-induced inflammation. Liver cancer can be caused by hepatitis B or C-induced inflammation. Lymphoma can be caused by Epstein Barr (the virus that causes mononucleosis) -induced inflammation. Cervical cancer can be caused by Human papillomavirus (the virus that causes genital warts)-induced inflammation. Kidney cancer can be caused by kidney stone-induced inflammation. And colon cancer can be caused by irritable bowel syndrome-induced inflammation. Whether the inflammation is caused by an infection (such as hepatitis), a mechanical irritant (such as kidney stones), or a chemical irritant (such as stomach acid), the result is the same. Chronic, low-grade inflammation greatly increases your risk of developing cancer.”

Dr. Johannes Fibiger was a Danish scientist, physician, and professor of pathological anatomy who won the Nobel Prize in Physiology or Medicine in 1926 for achieving the first controlled induction of cancer in laboratory animals, a development of profound importance to cancer research.[1] In 1907, while dissecting rats infected with tuberculosis, he found tumors in the stomachs of three animals. After intensive research, he concluded that the tumors, apparently malignant, followed an inflammation of stomach tissue caused by the larvae of a worm now known as Gongylonema neoplasticum. Fibiger’s work immediately led the Japanese pathologist Yamagiwa Katsusaburo to produce cancer in laboratory animals by painting their skins with coal-tar derivatives, a procedure soon adopted by Fibiger himself.

“Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells,” say researchers from Departments of Pharmacology and Pathology, School of Medicine, University of California in San Diego.

Biologists have been able to follow the inflammation link down to the level of individual signaling molecules, providing harder evidence for a connection to carcinogenesis.[2] Inflammation is the root of pain and most illnesses like diabetes and heart disease.

The association between chronic inflammation and tumor development was known to the early work of German pathologist Rudolph Virchow. Harvard University pathologist Dr. Harold Dvorak later compared tumors with “wounds that never heal,” noting the similarities between normal inflammation processes that characterize wound healing and tumorigenesis or tumor formation.

“Cancer is caused by many different processes and inflammation is one of them, and if you could inhibit that process it would be tremendously helpful,” says Dr. Young S. Kim, program director in the Nutritional Science Research Group at the National Cancer Institute.[3] Inflammatory chemicals release free radicals and free roving electrons that damage cells and may initiate damage to the genetic material in our cells, thus leading to cellular mutations, loss of normal cell functions and cancer. Inflammatory chemicals also stimulate the production of new capillaries, tiny blood vessels that feed cancerous growths.

In 2008 Scientific American published, “Cancer biologists and immunologists have begun to realize that the progression from diseased tissue to full-blown invasive cancer often requires cells that normally participate in healing cuts and scrapes to be diverted to the environs of the pre-malignant tissue, where they are hijacked to become co-conspirators that aid and abet carcinogenesis. As some researchers have described the malignant state: genetic damage is the match that lights the fire, and inflammation is the fuel that feeds it.”

Scientific American presents a view of cancer that implies that, “Rooting out every last cancer cell in the body might not be necessary. Anti-inflammatory cancer therapy instead would prevent pre-malignant cells from turning fully cancerous or would impede an existing tumor from spreading to distant sites in the body. Understanding chronic inflammation, which contributes to heart disease, Alzheimer's and a variety of other ailments, may be a key to unlocking the mysteries of cancer.”

As far back as 2004 investigators at the University of California, San Diego (UCSD) School of Medicine were suggesting a new strategy for cancer therapy, which converts the tumor-promoting effect of the immune system’s inflammatory response into a cancer-killing outcome.[4]

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Dr. Sergei I. Grivennikov writes, “The presence of leukocytes within tumors, observed in the 19th century by Rudolf Virchow, provided the first indication of a possible link between inflammation and cancer. Yet, it is only during the last decade that clear evidence has been obtained that inflammation plays a critical role in tumorigenesis, and some of the underlying molecular mechanisms have been eluci-dated. A role for inflammation in tumorigenesis is now generally accepted, and it has become evident that an inflammatory microenvironment is an essential component of all tumors. Only a minority of all cancers are caused by germline mutations, whereas the vast majority (90%) are linked to somatic mutations and environmental factors.”

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Dr. Vijay Nair's book Prevent Cancer, Strokes, Heart Attacks and other Deadly Killers says, “Colon cancer, stomach cancer, esophageal cancer, lung cancer, liver cancer, breast cancer, cervical cancer, ovarian cancer, prostate cancer, and pancreatic cancer have all been linked to inflammation. This is great news, because it means that cancer does not just strike out of nowhere. It’s preventable!”

The role of heavy metals is very important in the rise of cancer rates.[5],[6] We are poisoning the world over and over again with heavy metals and our brain cells and other tissues are suffering for it. Over 80% of heavy metals are removed from the body via the friendly bacteria in the gut but unfortunately we have had maniacs in control of western medicine encouraging doctors to over use antibiotics, which kill off the friendly bacteria in the gut. Heavy metal contamination creates inflammation!

Periodontitis, Inflammation and Cancer

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According to an article published in the Archives of Otolaryngology—Head and Neck Surgery, chronic periodontitis is associated with an increased risk of developing cancer of the tongue among men. Researchers at the University at Buffalo and Roswell Park Cancer Institute have found the same thing. Another recent study published in the Journal of the National Cancer Institute linked periodontal disease to pancreatic cancer as well. “Our study provides the first strong evidence that periodontal disease may increase the risk of pancreatic cancer,” said Dr Dominique Michaud of the Harvard School of Public Health in Boston, who led the research. Men with a history of periodontal disease had a 64 per cent increased risk of pancreatic cancer than men with no such history.

Inflammatory reactions in the body are a valuable predictor of impending heart attack. Dr. Robert Genko, editor of the American Academy of Periodontal Journal, claims that persons with gingival disease (which is an inflammatory disorder) are 27 times more likely to suffer a heart attack than are persons with healthy gums. An American Heart Association paper disclosed that 85% of heart attack victims had gum disease compared to 29% of healthy similar patients.

And increased severity of periodontitis, for example with recent tooth loss, had the greatest risk. People with periodontal disease have an increased level of inflammatory markers such as C reactive protein (CRP) in their blood. These markers are part of an early immune system response to persistent inflammation and have been linked to the development of pancreatic cancer. It is the high levels of carcinogenic compounds (especially mercury) that are present in the mouths of people with periodontal disease that increases risk of pancreatic cancer.

Vascular Brownout


Vascular Brownout occurs when a hypoxic stress event causes inflammation in the vascular endothelium. This shrinks the inside size of the pipes that carry blood into a bottleneck. Each bottleneck, inhibits blood flow to choke off oxygen to downstream tissue. This choke has three adverse effects:

Tissue Brownout – tissue is locked into low energy from hypoxia;

Concentrates Toxins – because blood flow that would normally wash it out is limited;

Reduced Immunity – so the area is less protected from infection than normal tissue;

Accelerated Aging – Stressed cells don’t live as long so the body is forced to replace them.

Tissue brownouts trigger a triple pH dysfunction. First, anaerobic cells produce lactic acid; second anaerobic cells cease production of carbon dioxide, third the bottleneck that inhibits blood flow causes waste products to linger, creating an area prone to “acid” soreness as waste product irritate tissue. These areas are unable to perform because their energy is reduced to 1/19 normal.

Carbon dioxide executes uncountable functions in the human organism. Among them are: repair of alveoli in lungs, stability of the nerve cells, regulation of pulse, normal immunity, blood pressure maintenance, dilation of bronchi and bronchioles, regulation of blood pH, sleep control, relaxation of muscle cells, release of O2 in capillaries (the Bohr effect), weight monitoring and tens of other essential functions.

Hemoglobin helps to transport hydrogen ions and carbon dioxide in addition to transporting oxygen. However, transport by hemoglobin accounts for only about 14% of the total transport of these species; both hydrogen ions and carbon dioxide are also transported in the blood as bicarbonate (HCO3-) formed spontaneously or through the action of carbonic anhydrase.

Sodium bicarbonate (baking soda) is the stunning medicine it is because it puts doctors’ and patients’ fingers on the CO2 pulse of the body. Bicarbonate intake raises the CO2 levels in the blood. On top of everything is the fact that CO2 is a key regulator of inflammatory reactions due to control of cells oxygen supply. Bicarbonate also regulates inflammatory reactions due to rapid changes in tissue and fluid pH.

In all serious disease states we find a concomitant
low-oxygen state. Low oxygen in the body tissues is a sure
indicator for disease. Hypoxia, or lack of oxygen in the
tissues, is the fundamental cause for all degenerative disease.
-Dr. Stephen Levine
Molecular Biologist

The effect of bicarbonate is instant and can be intense, as an athlete might tell you when taking bicarbonate before an event. Refining this process we can jump up to a new level with a higher octane bicarbonate formula that yields the ultimate mitochondrial cocktail—which is magnesium bicarbonate with some potassium bicarbonate thrown in—in a lemon water spritz drink you just make up yourself.

In order to survive, the body must maintain proper acid/alkaline (pH) balance because when it does not do so, tissue oxygen levels suffer. The optimum (and required) pH of the blood is somewhat alkaline, between 7.35 and 7.45. Only in this range is the blood richly supplied with oxygen. (Realize that if your blood pH varies just a little bit, it can kill you.) The vast majority of terminal cancer patients are a thousand times more acidic than normal healthy people, meaning their tissues have a very low pH and very low levels of oxygen throughout their entire body.

Oxygen, Inflammation & Hypoxia-Inducible Factor (HIF-1)


Scientists in Germany have shown that microenvironment of inflamed and injured tissues are typically characterized by low levels of oxygen and glucose and high levels of inflammatory cytokines, reactive oxygen, and nitrogen species and metabolites. Recent medical research has suggested that there is a strong link between cell hypoxia (oxygen deficiency in cells) and chronic inflammatory processes.

Inflammation is the most common causes of tissue hypoxia and/or decreased circulation. Both inflamed tissues as well as the areas surrounding malignant tumors are characterized by hypoxia and low concentrations of glucose. Inflammation can lead to sepsis, circulatory collapse and ultimately multi-system organ failure.

Tissue hypoxia is manifested in increased levels of hypoxia-inducible factor (HIF-1) (this factor and cell hypoxia are key factors in the progress of cancer). Elevated HIF-1 triggers a cascade of events with involvement of pro-inflammatory transcription factors such as nuclear factor kappa B (or NF-kappaB) and activator protein AP-1.

Hypoxia-inducible factor 1 (HIF-1) is known to be a master regulator of hypoxic response. Researchers have found that low levels of magnesium suppresses reactive-oxygen-species- (ROS) induced HIF-1. HIF-1a regulates the expression of at least 30 genes when oxygen levels are low. Magnesium deficiency depresses HIF-1 activity. This is the basis of excessive inflammatory immune response (sepsis) that contributes to the patient’s death. On intensive care units, sepsis is the second-most common cause of death worldwide.

Cancer & HIF-1


“Radiation and chemotherapy do kill most solid tumor cells, but in the cells that survive, the therapies drive an increase in HIF-1, which cells use to get the oxygen they need by increasing blood vessel growth into the tumor. Solid tumors generally have low supplies of oxygen and HIF-1 helps them get the oxygen they need,” explains Dr. Mark W. Dewhirst, professor of radiation oncology at Duke University Medical Center.

Dr. Holger K. Eltzschig, a professor of anesthesiology, medicine, cell biology and immunology at the University of Colorado School of Medicine, says, “Understanding how hypoxia is linked to inflammation may help save lives. By focusing on the molecular pathways the body uses to battle hypoxia, we may be able help patients who undergo organ transplants, who suffer from infections or who have cancer.”

Researchers found that an increase of 1.2 metabolic units
(oxygen consumption) was related to a decreased risk of
cancer death, especially in lung and gastrointestinal cancers.
[7]

In order for cancer to “establish” a foothold in the body it has to be deprived of oxygen and become acidic. If these two conditions can be reversed cancer not only can be slowed down, but it also can actually be overturned.

Drs. D. F. Treacher and R. M. Leach write, “Prevention, early identification, and correction of tissue hypoxia are essential skills. If oxygen supply fails, even for a few minutes, tissue hypoxaemia may develop resulting in anaerobic metabolism and production of lactate.”[8]

Inflammation interferes with oxygen transfer to cells, and since low oxygen conditions are a basic cause of cancer we need to study how inflammation causes cancer. “It is believed that cancer is caused by an accumulation of mutations in cells of the body,” says Dr. Carlo M. Croce, professor and chair of molecular virology, immunology and medical genetics. “Our study suggests that miR-155, which is associated with inflammation, increases the mutation rate and might be a key player in inflammation-induced cancers generally.” This and many other studies show how inflammation can cause cancer. Chronic inflammation due to infection or to conditions such as chronic inflammatory bowel disease is associated with up to 25% or more of all cancers.

Professor Manfred von Ardenne wrote, “Because more than 80% of all cancer deaths are caused by metastases, development and evaluation of methods for fighting tumor dissemination should be major tasks of present cancer research. Formation of metastases is favoured by both reduced numbers of immune cells in the bloodstream and impaired oxygen transport into tissues.”

Hypoxia Promotes Inflammation


Anything that threatens the oxygen-carrying capacity of the human body will promote inflammation and cancer growth. The data shows that magnesium-deficient people use more oxygen during physical activity—their heart rates increased by about 10 beats per minute. “When the volunteers were low in magnesium, they needed more energy and more oxygen to do low-level activities than when they were in adequate-magnesium status,” says physiologist Henry C. Lukaski.[9]

Magnesium enhances the binding of oxygen to haem proteins.[10] There is probably some kind of magnesium pump where oxygen climbs aboard the red cells and magnesium jumps off only to have to jump right back on the red cells again. Red blood cells have a unique shape known as a biconcave disk, which is mission-critical for oxygen transport. Magnesium is important to red blood cell shape and function. The interaction of calcium, magnesium and ATP with membrane structural proteins exerts a significant role in the control of the shape of human red blood cells.[11]

Abnormal magnesium-deprived red blood cells lack the flexibility that allows them to enter tiny capillaries. These nondiscocytes are characterized by a variety of irregularities, including surface bumps or ridges, a cup or basin shape, and altered margins instead of the round shape found in discocytes. When people become ill or physically stressed (more magnesium-deficient), a higher percentage of discocytes transform into the less flexible nondiscocytes.

Magnesium Deficiencies and Inflammation


Inflammation is the missing link to explain the role of
magnesium in many pathological conditions including cancer.

Magnesium deficiency causes and underpins chronic inflammatory build ups. Dr. A. Mazur et al[12] have shown in experimentally induced magnesium deficiency in rats that after only a few days a clinical inflammatory syndrome develops and is characterized by leukocyte (white blood cell) and macrophage activation, release of inflammatory cytokines and excessive production of free radicals. “Magnesium deficiency induces a systemic stress response by activation of neuro endocrinological pathways,” writes Dr. Mazur. “Magnesium deficiency contributes to an exaggerated response to immune stress and oxidative stress is the consequence of the inflammatory response,” he continued.

Increases in extracellular magnesium concentration cause a decrease in the inflammatory response while reduction in the extracellular magnesium results in inflammation. Inflammation causes endothelial dysfunction and activated endothelium facilitates adhesion and migration of cancer cells. Magnesium literally puts the chill on inflammation.

It is magnesium that modulates cellular events involved in inflammation. A silent kind of inflammation has an insidious nature and is the culprit behind diabetes and heart disease. The chronic and continuous low-level stress that silent inflammation places on the body’s defense systems often results in an immune-system breakdown. Magnesium deficiency is a parallel silent insult happening at the core of our physiology. Magnesium deficiencies feed the fires of inflammation and pain.

Depression, Sleep Disorders and Inflammation


Depression also is correlated with inflammation. A study conducted by researchers at the Emory University School of Medicine found that psychological stress leads to an excessive inflammatory response in people. Their findings published in the American Journal of Psychiatry showed that individuals who suffer from depression are more likely develop an inflammatory response due to the emotional disorder than people who are not depressed.

People with poor quality sleep or sleep deprivation exhibit increased levels of interleukin-6 (IL6), the chemical that causes inflammation throughout the body. According to the National Sleep Foundation approximately 70 million people in the United States are affected with sleeping disorders. Magnesium provides a calming effect that allows for deeper relaxation and better sleep. Magnesium is considered the “antistress” mineral. It is a natural tranquilizer which functions to relax skeletal muscles as well as the smooth muscles of blood vessels and the gastrointestinal tract. It should come as no surprise that magnesium supplementation has a strong effect on depression.

Flood the Body with Magnesium for Best Results


It is almost impossible to give too much magnesium. The worst that happens is the intestines let loose unless the patient is experiencing late stage kidney failure. Cancer patients want to take magnesium orally with daily massages, magnesium and bicarbonate baths and by taking different forms orally.

Another reason, not mentioned above is that magnesium is exceedingly important for proteolytic enzymes, which counteract the inflammation, and things return to normal. That’s why a sprained ankle as a young child heals within a few weeks at most, but can take six weeks or more for an adult of say 45. The problem is, after around age 25, our production of these enzymes drops off almost completely so there is nothing to tell the body to stop the inflammation.

These enzymes are also responsible for cleaning the blood, fighting off viral and bacterial infections and breaking down excess fibrin (scar tissue). Most if not all of these enzymes are mediated by magnesium meaning as magnesium levels drop off so do the activities of these crucial biological magnesium sensitive enzymes. Enzymes are very important in inflammation and enzymes bring us back to their fundamental supporter, which is magnesium.

Dehydration, Inflammation and Oxygen


Along with inflammation, stress, heavy metals, low oxygen conditions and acidity, dehydration is another primary cause of inflammation. Cancer and inflammation are bedfellows so we should understand the connection between inflammation and chronic dehydration. Nothing kills a person faster than dehydration except cessation of respiration.

Dehydration is not just about low water intake, but also insufficient electrolytes. Without a good balance of water and electrolytes in our system it is difficult for blood, and thus oxygen to reach all parts of the body. Because water and electrolytes are so crucial to the functioning of every cell their lack creates all kinds of problems.

Dehydration has been shown to increase production of histamine leading to a general, widespread inflammatory response.[13] This complicates the Cytokine Storms that come for Ebola patients and that is why rehydration is one of the principle treatments for Ebola.

Dehydration includes the following consequences to our physiology:

  • DNA damage, which can lead to mutant (cancerous) cells.
  • Acid-alkaline balance. When dehydrated and urine output is diminished, acid waste accumulates in weak or vulnerable areas of the body. It is well known that a cancerous body is acidic.
  • Cell receptor damage. Chronic dehydration causes enzymatic changes that lead to numerous problems with cellular communication and hormonal balance.
  • Immune system suppression. Dehydration suppresses the immune system because histamine production in the body is increased, which also increases the production of a chemical called vasopressin, a strong suppressor of the immune system.

Water is the primary transport of oxygen to the cells. Water is also the primary transport for the removal of toxins out of the cells and out of the body so we can understand that dehydration leads to pathology.

Water shortages create oxygen shortages as well as acid pH so water is a serious medicine—it cures dehydration and makes the difference between life and death for Ebola and influenza patients. Inflammation is cytotoxic and can kill cells prematurely.

Developed in the late 1960s by Professor von Ardenne, (a student of Dr. Otto Warburg, best known for his pioneering research on the connection between lack of oxygen and cancer), Oxygen Multistep Therapy combines oxygen therapy, drugs that facilitate intracellular oxygen turnover, and physical exercise adapted to individual performance levels. This unique therapy has diversified into more than 20 different treatment variants and is now practiced in several hundred settings throughout Europe. Ardenne put his finger on how inflammation interferes with oxygen transfer to cells.

“It is believed that cancer is caused by an accumulation of mutations in cells of the body,” says Dr. Carlo M. Croce, professor and chair of molecular virology, immunology and medical genetics. “Our study suggests that miR-155, which is associated with inflammation, increases the mutation rate and might be a key player in inflammation-induced cancers generally.” This and many other studies show how inflammation can help cause cancer. Chronic inflammation due to infection or to conditions such as chronic inflammatory bowel disease is associated with up to 25% of all cancers.

Anti-Inflammatory Oxygen Therapy Treatment for Inflammation

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Book in Print
EBook

Professor Ardenne wrote[14], “Because more than 80% of all cancer deaths are caused by metastases, development and evaluation of methods for fighting tumor dissemination should be major tasks of present cancer research. Formation of metastases is favoured by both reduced numbers of immune cells in the bloodstream and impaired oxygen transport into tissues. These closely related signs often emerge concomitantly when the organism is endangered by circulating tumor cells released from the original tumor by therapeutic manipulations. From knowledge of these facts the O2-multistep immune-stimulation technique has been developed as a way of diminishing the risk of tumor spread. The process combines temporary elevation of the number of circulating immune cells with continuous improvement of oxygen transport into tissues.

When the oxygen saturation of blood falls, conditions then become ripe for the creation of cancer. Oxygen is exchanged and removed from the arterial blood as it passes through the capillary system. If arterial blood is deficient in oxygen or if blocked arteries restrict the blood flow, then tissues oxygenated by the latter stages of the capillary system may be so deprived of oxygen as to become cancerous.

People with various degenerative diseases are often found to have low venous oxygen saturation. Once they receive proper treatment, the venous oxygen saturation level rises and their health and vitality improve dramatically.

Arterial oxygen saturation should ideally be very high. “High O2 tensions were lethal to cancer tissue, 95% being very toxic, whereas in general, normal tissue were not harmed by high oxygen tensions. Indeed, some tissues were found to require high O2 tensions”, J. B. Kizer quoted in “O2Xygen Therapies: A New Way of Approaching Disease” by McCabe, page 82.

He discovered a "switch mechanism" of blood microcirculation, which depends on the oxygen state of the body. A high value of pO2 (greater than or equal to 50 mm of Hg) at the venous ends of the capillaries, attainable by the procedures of the Oxygen Multistep Therapy and by powerful physical exercise as well, results in an increase of the blood microcirculation and, consequently, in a permanent elevation of the oxygen influx and uptake, respectively.

Anti-Inflammatory Oxygen Therapy increases the blood microcirculation and consequently we see a permanent elevation of the oxygen influx and uptake.

http://med.ardenne.de/wp-content/uploads/2012/03/smt_diagramm_eng.jpg

If the oxygen state gets worse and declines below a certain threshold, e.g. in progressing age or after long-term distress, the cross sections of the capillaries shrink by swelling of the endothelial cells, and the blood microcirculation will be diminished for an extended period. Reversing this degradation is quite a medical feat.

The utilization of the above-mentioned switch mechanism for permanent improvement of the oxygen flux into all the tissues of the organism is of decisive importance for fighting against the common cause of many diseases, disorders and complaints often going along with increasing age due to an insufficient oxygen (energy) supply for general metabolism.

Diagram of blood vessel structures.

On Professor von Ardenne’s site they say that, “This switching mechanism is interpreted as a re-enlargement of the capillary narrowed by oxygen deficiency (old age, disease, distress). The re-enlargement appears after increased oxygen uptake of the blood and improved oxygen utilization of human tissue over a certain time period.”

Prof. Dr. Manfred von Ardenne

Resolved inflammation restores the blood supply to tissue – and allows the tissue to return to normal aerobic metabolism. Professor Ardenne showed that stress triggers persistent inflammation,which locks an escalating percentage of the body, and muscles into anaerobic metabolism – especially with advancing age.[15]

Hydrogen and Inflammation


The scientific research on hydrogen and inflammation is expanding rapidly with scientists finding that lipopolysaccharide (LPS)-induced inflammatory cascades. For the first time, revealed the novel mechanism underlying the inhibitory effect of molecular hydrogen on LPS-caused NLRP3 inflammasome activation, highlighting the promising application of hydrogen as an antioxidant in the treatment of LPS-associated inflammatory pathological damage.[16]

An anti-inflammatory effect of hyperbaric hydrogen on a mouse model of schistosomiasis-associated chronic liver inflammation was reported in 2001.[17]

Hydrogen-rich saline prevents Aβ-induced neuroinflammation and oxidative stress, which may contribute to the improvement of memory dysfunction in animal studies.[18]

Hypoxia is characteristic for sites of inflammation and lesion, and since most people suffer from some sort of inflammation in one part of the body or other, we need to declare inflammation as a main cause of low oxygen levels. Cell hypoxia is one of the main causes of free radical generation and oxidative stress leading to inflammation, especially in the capillaries. Capillaries are critical determinants of oxygen and nutrient delivery and utilization so inflammation there is telling.

The Worst Treatment for Inflammation is Aspirin

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Aspirin is a powerful anti-inflammatory agent, and researchers believe it can reduce the inflammation that can trigger heart attacks. In the case of cancer, the inflammation can cause damage that promotes abnormal cells like tumors to grow. But in 2014, the Food and Drug Administration (FDA) deemed that such preventive doses in otherwise healthy people produced more risk than benefit. Aspirin, which works to reduce inflammation, activates enzymes that can irritate stomach and intestinal tissues, causing ulcers and bleeding. For people who haven’t yet had a heart attack, therefore, the FDA determined that the risk of such side effects were too great compared to the potential benefit they might get.

A study published this year in the journal JAMA Neurology found that taking low-dose aspirin is associated with an increased risk for bleeding within the skull for people without heart disease. The studies run counter to what doctors had recommended for decades: taking 75 to 100 milligrams of aspirin daily to prevent strokes or heart attacks.

Always recommend magnesium over aspirin. Why? Prof Peter Rothwell, from the University of Oxford, said aspirin was causing around 20,000 bleeds annually - and causing at least 3,000 deaths in England alone. A study at Oxford found that those over the age of 75 who take the blood-thinning pills are ten times more likely than younger patients to suffer disabling or fatal bleeds.

In a large clr working as a firefighter, researchers have said.

Gastrointestiinical trial to determine the risks and benefits of daily low-dose aspirin in healthy older adults without previous cardiovascular events, aspirin did not prolong healthy, independent living (life free of dementia or persistent physical disability).

Mortality rate was 5.57% (95% CI = 4.9-6.7), and 5.62% (95% CI = 4.8-6.8) in study 1 and study 2, respectively. Death rate attributed to NSAID/aspirin use was between 21.0 and 24.8 cases/million people, respectively, or 15.3 deaths/100,000 NSAID/aspirin users. For magnesium zero. Taking an aspirin every day may help prevent heart disease and stroke but, for a middle-aged man, it is nearly as risky as driving a car onal side effects are:

  • ulcerations
  • abdominal burning
  • pain
  • cramping
  • nausea
  • gastritis, and
  • even serious gastrointestinal bleeding and
  • liver toxicity.

CBD significantly lowers plasma levels of the pro-inflammatory cytokines (proteins), INF-gamma and TNF-alpha, and significantly reduced the severity of insulitis compared to non-treated controls.

Cannabinoids and Inflammation


Both CBD and THC, which are the best-known and most medically significant cannabinoids, could act on immune functioning to trigger an anti-inflammatory response. Another review from the University of South Carolina indicated the immunological effects of cannabinoids were caused by the substances acting on cannabinoid receptors 1 and 2 in the body, which induced a number of changes and led to lower levels of inflammation according to research published in the journal Pharmacological Research. Cannabis has great promise as a potential treatment for inflammatory diseases. Some research has demonstrated CBD to be effective in reducing joint inflammation and swelling. THC has been implicated in the treatment of atherosclerosis.

It’s also worth noting cannabinoid receptors 1 and 2 are widely distributed in the digestive tract. If cannabis does have anti-inflammatory properties that work by acting on these receptors, it could mean it could play a role in controlling and treating inflammatory bowel disease.

Dr. Ester Fride strongly recommends the use of cannabinoids in pediatric medicine. She notes that “excellent clinical results” have been reported in pediatric oncology and in case studies of children with severe neurological diseases or brain trauma, and suggests that cannabis-derived medicines could also play a role in the treatment of other childhood syndromes, including the pain and gastrointestinal inflammation associated with cystic fibrosis.

Benefits of CBD Cannabidiol

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It has anti-inflammatory, anti-anxiety, anti-epileptic, sedative and neuro-protective actions. It is also a potent anti-oxidant, protecting against chemical damage due to oxidation. Studies have suggested that CBD could protect against the development of diabetes, certain kinds of cancer, rheumatoid arthritis, brain and nerve damage due to stroke, alcoholism, nausea, inflammatory bowel disease and Huntington’s disease. Medicine just does not get any better.

Conclusion


The granddaddy of all anti-inflammatory drugs is aspirin, which can cause more serious problems than it often alleviates. Most pain and anti-inflammatory medications are not safe; even the over the counter pain medications hold unforeseen dangers. Despite more than a decade’s worth of research showing that taking too much acetaminophen can ruin the liver, the number of severe, unintentional poisonings from the drug is on the rise, a new study reports. The drug, acetaminophen, is best known under the brand name Tylenol. Compounds containing Tylenol include Excedrin, Midol Teen Formula, Theraflu, Alka-Seltzer Plus Cold Medicine, and NyQuil Cold and Flu, as well as other over-the-counter drugs and many prescription narcotics, like Vicodin and Percocet.

Magnesium, molecular hydrogen and medical marijuana offer a much better alternative to aspirin and acetaminophen containing drugs and the same can be said for replacing opioids with these extremely safe effective natural medicines.

[1] http://annals.org/article.aspx?articleid=705483

[3] Nature; Oct. 2012

[4] University Of California, San Diego School Of Medicine. (2004, September 22). New Anti-inflammatory Strategy For Cancer Therapy Identified By UCSD Researchers. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2004/09/040921083931.htm

[5] http://www.psr.org/environment-and-health/confronting-toxics/heavy-metals/

[7] http://www.medicalnewstoday.com/articles/159225.php

[8] BMJ. 1998 November 7; 317(7168): 1302–1306

[9] http://www.agclassroom.org/teen/ars_pdf/family/2004/05lack_energy.pdf

[10] Terwilliger and Brown, 1993; Takenhiko and Weber; Wood and Dalgleish, 1973

[11] http://bloodjournal.hematologylibrary.org/cgi/reprint/44/4/583.pdf

[12] Mazur A, Maier JA, Rock E, Gueux E, Nowacki W, Rayssiguier Y. Magnesium and the inflammatory response: Potential physiopathological implications. Arch Biochem Biophys. 2006 Apr 19; PMID: 16712775Equipe Stress Metabolique et Micronutriments, Unite de Nutrition Humaine UMR 1019, Centre de Recherche en Nutrition Humaine d'Auvergne, INRA, Theix, St. Genes Champanelle, France.Arch Biochem Biophys. 2006 Apr 19

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