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Opening the Brain: Natural Strategies for Alzheimer’s and Cognitive Recovery

Published on March 24, 2025

Deaths from Alzheimer’s in America have soared 55 percent since 1999 as the burden of this fatal form of dementia grows and the population ages, a federal health report said. “Millions of Americans and their family members are profoundly affected by Alzheimer’s disease,” said former CDC Acting Director Anne Schuchat.

There is no cure for Alzheimer’s disease, the most common form of dementia, if you listen to your doctor. The most the Western medical establishment can say is, “Age is the greatest risk factor for Alzheimer’s disease.” More than five million people in the United States are living with Alzheimer’s, and that number could balloon to 16 million by 2050, according to the Alzheimer’s Association.

We are living through a silent epidemic of neurological decline. From Alzheimer’s to Parkinson’s, from early cognitive impairment to full-blown dementia, the suffering is multiplying—and it’s doing so in a world that keeps people in the dark about the causes and even darker about the cures. This document represents a new dawn in Alzheimer’s therapy.

The rise of Alzheimer’s disease and dementia reflects more than just aging populations—it’s a sign of neurological systems under siege. From toxic exposures to nutritional depletion, our brains are facing an onslaught.

Alzheimer’s Drugs Offer No Help

The mainstream medical system obsesses with pharmaceuticals that manage symptoms, not root causes. Mainstream medicine continues to chase symptom management and patentable drugs, but patients and families are left disappointed. It’s time for a new paradigm: restoring cellular function, improving blood flow, and removing what does not belong.

The New York Times published, “The drugs most commonly used to soothe agitation and aggression in people with Alzheimer’s disease are no more effective than placebos for most patients and put them at risk of serious side effects, including confusion, sleepiness, and Parkinson’s disease-like symptoms, researchers are reporting today.”

New Insights

One of the most critical therapeutic insights is that opening blood flow to the brain can reverse much of what we once considered irreversible. Until recently, cardiologists thought that blood narrowing and hardening of the arteries was impossible to reverse. However, as cholesterol-clearing agents, cyclodextrins open much more blood flow and, thus, oxygen to reach the brain.

Hydrogen medicine for anti-aging touches right into the core of this subject. Molecular Hydrogen is not just the smallest molecule—it may be the most potent antioxidant and neuroprotective agent known. Studies have shown hydrogen inhalation to:

  • Reduce oxidative stress and inflammation in brain tissue
  • Protect against amyloid-beta toxicity
  • Improve mitochondrial function and ATP production

Hydrogen, especially when combined with light therapy (photobiomodulation), can revitalize energy-starved neurons and protect against degenerative cascades.

With rising toxicity and declining nutrition, neurodegeneration is becoming common even at younger ages. Flu epidemics, mercury exposure, vaccine side effects, and poor dietary patterns contribute to the collapse of neurological integrity.

And at the end of the list below, we will add low-dose Lithium therapy.

It is still possible to Reverse Neurological Decay with A Full Protocol

  • Hydrogen/Oxygen Inhalation Therapy
  • Cyclodextrins for plaque clearance and circulatory support
  • Magnesium chloride (oral, topical, and injectable)
  • Sodium bicarbonate for pH balancing and detox support
  • Sunlight and infrared light for photobiomodulation
  • Selenium
  • Glutathione
  • Chlorine Dioxide
  • NBMI (also known as OSR)
  • CO2 Inhalation
  • Breathing Retraining
  • Lithium

Modern medicine often treats Alzheimer’s as an inevitable, mysterious disease with no cure. But a very different picture emerges if we shift the lens toward toxicity, nutrient deficiency, blood flow, and mitochondrial collapse.

Treating Alzheimer’s Disease Testimony

My mum, Eti, is 63 years old and has been diagnosed with severe Alzheimer’s disease. I approached Dr. Sircus 2 months ago when my mum was in a terrible physical and mental state. She hardly talked and did not manage to do anything by herself; she was very tense from the inside, bent over, and shuffled in her walk. Most of the day, she was in a zombie state.

She was treated, until my approach to Dr. Sircus, with conventional medications, which seemed to ruin her body and make her a Zombie. I had a strong feeling that it could not be that my mum would vanish so quickly and that there was nothing to do about it – as everyone believed.

For 3 weeks now, we have been giving my mum almost the full protocol, and the changes that are already happening are excellent compared to the terrible state she was in when starting. We are gradually taking her off the conventional medications (which include an anti-psychotic drug, anti-depression drug, and another drug “for Alzheimer”)

We are just beginning this journey, and she talks again – in complete sentences. Her shuffling walk is getting much better; she is standing almost straight, and most importantly, she is much more happy and connected to her environment. She laughs, makes jokes, enjoys the people around her, and enjoys films again. Most of the day, she is not a zombie at all! The day she remembered my name and called for me, I cried half the day.

Even though my mom still needs help in almost everything, her motor functions and her mental state are much better. I must say that 2 months ago, when we only started with the magnesium and sodium baths, that by itself helped her to be more relaxed.

I do not know what the limit of her improvement is, but we already see that Dr. Sircus’s protocol makes a change – and in her terrible disease – every small change is a big one.

I want to say that Dr. Sircus is a true partner in making my mom better, and his heart and mind are always open to us. I feel he is driven out of a deep care for human beings, and he is brave enough to check a new way that makes it possible for my mom to start to heal.

Maya from Israel.

Magnesium’s Neuroprotective Role

Magnesium deficiency, one of the core pillars of neurological degeneration, is overlooked in nearly every neurological assessment. Yet it plays a central role in blood vessel integrity, brain metabolism, and the calming of the nervous system. Without magnesium, the brain becomes electrically unstable, emotionally erratic, and metabolically starved. Strokes and heart attacks attributed to “natural causes” often stem from long-standing magnesium depletion. Magnesium helps reduce inflammation all over the body, including the brain.

Magnesium is essential for numerous physiological processes, including nerve transmission and muscle function. Its deficiency has been linked to various neurological disorders. Adequate magnesium levels are crucial for maintaining vascular health and neuronal function and protecting against excitotoxicity, all of which are vital in the context of Alzheimer’s disease.

Cyclodextrins: Opening Blood Flow and Clearing Cellular Debris

Used initially to dissolve cholesterol-based plaques in cardiovascular medicine, cyclodextrins have promising implications for the brain. Their ability to:

  • Solubilize and remove intracellular debris
  • Enhance endothelial function
  • Improve microvascular blood flow

Cyclodextrins are ideal for supporting cerebral circulation. In Alzheimer’s, where brain blood flow can drop by up to 30% in key areas, restoring perfusion is essential. Cyclodextrins don’t just unclog peripheral arteries. They penetrate deep tissue, bind to harmful lipids and toxins, and assist in cleansing vascular pathways—including those to the brain. Helping clear cholesterol deposits and plaque allows oxygen, nutrients, and natural medicines to reach regions long cut off by microvascular collapse.

Cyclodextrins, cyclic oligosaccharides, have garnered attention for their ability to interact with lipids and influence membrane dynamics. Research indicates that cyclodextrins can assist in the treatment of neurological disorders by interacting with plasma membranes and extracting different lipids, which is relevant at the level of the blood-brain barrier (BBB). This property suggests that cyclodextrins could enhance the delivery of therapeutic agents to the brain, potentially improving outcomes in neurodegenerative diseases.

Pair this with molecular Hydrogen, and we begin a revolution. Hydrogen, the most selective antioxidant in the universe, is small enough to reach the innermost cellular compartments, quenching hydroxyl radicals and reducing oxidative stress in the brain. It not only protects brain cells—it awakens them.

Molecular Hydrogen Therapy

Recent studies have demonstrated that molecular Hydrogen (H₂) possesses significant neuroprotective properties. Its antioxidant and anti-inflammatory effects can ameliorate neuronal damage, maintain neuronal integrity, and potentially inhibit the progression of neurodegenerative diseases like Alzheimer’s. For instance, a study indicated that H₂ treatment alleviated temporary symptoms and had disease-modifying effects, suggesting its potential in AD management.

Mercury Toxicity and Alzheimer’s:
A Hidden Catalyst for Neurodegeneration

Alzheimer’s disease, the most common form of dementia, is typically described in terms of amyloid plaques, tau tangles, and neuroinflammation. But beneath this mainstream narrative lies a silent contributor rarely acknowledged by conventional medicine: heavy metal toxicity, especially from mercury.

Mercury is a potent neurotoxin. It accumulates in fatty tissues—including the brain—disrupting enzymatic function, mitochondrial energy production, and most notably, depleting glutathione, the body’s master antioxidant. The central nervous system is particularly vulnerable, and long-term exposure to mercury, even in small amounts, has been shown to mimic the very patterns of neurological degeneration observed in Alzheimer’s.

Multiple studies and clinical observations have drawn attention to this connection:

  • Mercury disrupts tubulin polymerization, a key structural component of neurons—just as tau tangles do.
  • Mercury increases oxidative stress, leading to inflammation and cellular damage.
  • Mercury impairs glutamate clearance, contributing to excitotoxicity and synaptic failure.
  • Mercury depletes glutathione and selenium, both critical for detoxifying brain tissue and maintaining redox balance.

Traditional chelation therapies like EDTA and DMSA have limitations. They tend to remain extracellular, lack selectivity for mercury, and often cannot cross the blood-brain barrier, critical for addressing central nervous system (CNS) toxicity. They may also deplete essential minerals, further weakening already fragile patients.

This is where Dr. Boyd Haley’s innovation—NBMI (also known as OSR)—enters as a game-changer. Dr. Haley, former Chair of the Chemistry Department at the University of Kentucky, spent years studying mercury toxicity and its role in neurodegenerative diseases. His molecule, N,N′-bis(2-mercaptoethyl)isophthalamide (NBMI), is a synthetic compound designed to mimic and enhance the chelating properties of glutathione, but with several advantages:

Why is NBMI Unique and Powerful?

  • Lipophilic: Unlike most chelators, NBMI is fat-soluble, meaning it can cross cell membranes and the blood-brain barrier, directly targeting mercury in the brain.
  • High Affinity for Mercury: NBMI binds selectively and irreversibly to toxic metals—mainly mercury—neutralizing their oxidative and biochemical damage.
  • Anti-Inflammatory: NBMI not only chelates heavy metals but also reduces oxidative stress, helping to calm the inflammatory cascade in the brain.
  • Non-Toxic: Animal and human safety studies have shown NBMI to be remarkably safe, with no evidence of toxicity even at high doses.
  • Restores Glutathione Pathways: NBMI supports and protects glutathione stores rather than depleting them—making it a regenerative therapy, not just a detox agent.

Incorporating NBMI into a broader neuro-regeneration and detox protocol offers a new paradigm for treating and possibly reversing early-stage Alzheimer’s and other neurodegenerative conditions:

  • Targeted detoxification of mercury from brain tissues
  • Reduction of oxidative damage and mitochondrial dysfunction
  • Improvement of neuronal signaling and synaptic resilience
  • Protection of brain vasculature, especially when combined with agents like cyclodextrins (which help dissolve cholesterol-based plaques) and magnesium (which improves blood flow, calms the nervous system, and protects the brain from calcium-induced excitotoxicity)

Chlorine Dioxide (CD)

When people bring up CD in the context of Alzheimer’s—or any degenerative disease—they’re not thinking about bleach. They’re thinking about oxidation therapy, about radical ways to cleanse a toxic internal environment where metals like mercury have quietly wreaked havoc for decades.

They’re thinking: What if the problem is biofilms, chronic infections, hidden inflammation? What if Alzheimer’s is not just a genetic misfortune but a toxic storm of mercury, aluminum, pesticides, parasites, mold, and inflammation starving the brain of oxygen, Hydrogen, magnesium, and flow?

Chlorine dioxide hasn’t been through the double-blind billion-dollar pharma trials. But recognize that CD is a potent oxidizer and microbial disruptor. Some alternative protocols use it to target brain fog, systemic inflammation, and even viral or bacterial loads believed to contribute to neurodegeneration. Frame chlorine dioxide alongside Hydrogen, magnesium, cyclodextrins, glutathione, and NBMI as part of an anti-stagnation, pro-circulation, detoxification-based model of brain recovery.

Extracted from an Italian Audio Testimonial, voice-to-text, then translated from Italian to English.

CDS is chlorine dioxide gas dissolved in water.

“Regarding my 81-year-old mother, a strong clinical picture of Cognitive Degeneration and Parkinson’s Disease.

Until a month ago, Mother was as if closed in her own world, very mute, completely devoid of emotion and expression. After the first week of taking CDS eight times a day in a bit of water with a very low dosage, I think 5 ml. After the first week, my son and I noticed the first incredible improvements, specifically regarding speech. That is my mother, who didn’t speak began to make long speeches, remembering things from 50 years ago.

Today, after just over a month of treatment, we have reached 10 ml of CDS a day, and my mother is a completely different person. She walks in a much more upright position, no longer rubs her feet, and helps me do the housework.

Two months ago, she was utterly self-sufficient, and today, for example, she empties and loads the whole dishwasher for me.

She gets up every hour to get herself the CDS. Another aspect that was absolutely unthinkable a month ago was that my mother was in bed all day. So, it was inconceivable for me that she could get up, go to the kitchen, take the CDS out of the fridge, pour it into the cup, add water… unthinkable.

I bought her an album of mandalas, she colors them.

The other incredible aspect is that I am slowly reducing her medicines: the triptych, the one for depression that she took in the evening, as well as the Sinemet, which is a medicine for muscle stiffness.

So I am shocked after only a month by the incredible miraculous results, and she is thrilled, and we will take CDS for life, that’s for sure.”

Lithium

Dr. Michael Nehls, a German physician and molecular geneticist, has extensively explored the role of lithium as an essential trace element in promoting mental health and potentially preventing neurodegenerative diseases like Alzheimer’s. Sebastos+2Google Books+2Android Apps on Google Play+2

Lithium’s Neuroprotective Properties:

Dr. Nehls posits that even microdoses of lithium can have significant neuroprotective effects. He suggests that such doses may slow cognitive decline and possibly prevent the progression of Alzheimer’s disease. Lithium is naturally present in certain foods, including spinach and shellfish, making dietary intake a potential avenue for obtaining this trace element. Sebastos

Unified Theory of Alzheimer’s Disease (UTAD):

In his research, Dr. Nehls proposes the Unified Theory of Alzheimer’s Disease (UTAD), which emphasizes the importance of adult hippocampal neurogenesis (AHN) in maintaining cognitive function. He argues that lifestyle factors impairing AHN can initiate Alzheimer’s disease processes. Within this framework, lithium’s role in promoting neurogenesis and neuronal rejuvenation is highlighted as a potential preventive and therapeutic strategy against Alzheimer’s. ResearchGate+1PMC+1PMC+1Sebastos+1

Lifestyle and Nutritional Factors:

Dr. Nehls underscores the significance of a healthy lifestyle in preventing cognitive decline. He advocates for regular physical activity, a balanced diet rich in omega-3 fatty acids, adequate vitamin D levels, and sufficient lithium intake. These factors collectively support hippocampal health and may reduce the risk of developing Alzheimer’s disease. PMC+4Sebastos+4Google Books+4

Dr. Nehls’ work suggests that lithium, even in trace amounts, plays a crucial role in maintaining mental health and offers promise in preventing or mitigating neurodegenerative diseases like Alzheimer’s. His holistic approach integrates lifestyle and nutritional interventions to support cognitive function and overall brain health.

Conclusion

Incorporating these strategies into a comprehensive treatment plan could provide a multifaceted defense against Alzheimer’s disease, addressing both symptom management and underlying pathophysiological mechanisms.

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Hi, I'm Dr. Mark Sircus, AC., OMD, DM (P), a doctor and writer of more than 23 books that have sold over 80,000 copies all over the world. My first major book was "Transdermal Magnesium Therapy" which afforded me the title of "Magnesium Man." It has been translated into five languages and has reduced the suffering of many people.

On my website there are hundreds if not a thousand free articles, so you can dive deep into my work. However if you need personalized help, you are more than welcome to schedule a consultation.

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